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ABT-751

Phase 2

Breast Cancer | Small molecule | Oncology |Abbott Laboratories|Last Updated: Nov 29, 2007

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

ABT-751 · 4 trials · 4 indications

Phase 2 4
NCT00073151A Study of ABT-751 in Patients With Non-Small Cell Lung CancerNon-Small Cell Lung Cancer
COMPLETED30 Analytics
NCT00073112A Study of ABT-751 in Patients With Renal Cell CancerRenal Cell Cancer
COMPLETED60 Analytics
NCT00073138A Study of ABT-751 in Patients With Colorectal CancerColorectal Cancer
COMPLETED40 Analytics
NCT00063102A Study of ABT-751 in Patients With Recurrent Breast Cancer After Taxane (Taxol or Taxotere) Therapy.Breast Cancer
COMPLETED40 Analytics
PHASE2COMPLETED
A Study of ABT-751 in Patients With Non-Small Cell Lung Cancer
Non-Small Cell Lung CancerUnlock trial analytics
PHASE2COMPLETED
A Study of ABT-751 in Patients With Renal Cell Cancer
Renal Cell CancerUnlock trial analytics
PHASE2COMPLETED
A Study of ABT-751 in Patients With Colorectal Cancer
Colorectal CancerUnlock trial analytics
PHASE2COMPLETED
A Study of ABT-751 in Patients With Recurrent Breast Cancer After Taxane (Taxol or Taxotere) Therapy.
Breast CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Objective Response Rate in subjects with NSCLC
1 year
Objective Response Rate in subjects with RCC
1 year
Objective Response Rate in subjects with Recurrent Colorectal Cancer
1 year
Objective Response Rate in subjects with Breast cancer
1 year

Secondary Endpoints

Time to Tumor Progression (TTP)
1 year
Survival
2 years
Toxicities associated with treatment administration
1 year
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
ABT-751DRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites17

Inclusion Criteria * Stage IIIB or IV non-small cell lung cancer. * Recurrent tumor following treatment with paclitaxel or docetaxel. * Able to tolerate normal activities of daily living. * Adequate bone marrow, kidney and liver function. Exclusion Criteria * Pregnant or breast feeding. * Anti-tu...

Countries:United StatesCanada
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Competitive Landscape -Breast Cancer 402 trials

Top 20 of 92 competitors

CompanyTickerTrialsLead PhaseDrugs
AstraZeneca PLCAZN47PHASE3Fulvestrant, Capivasertib
Merck & Co., Inc.MRK12PHASE3Pembrolizumab, Paclitaxel, Doxorubicin, Epirubicin, Cyclophosphamide
Eli Lilly and CompanyLLY27PHASE3Abemaciclib, Standard Adjuvant Endocrine Therapy
BioNTech SE Sponsored ADRBNTX7PHASE3DB-1303/BNT323, T-DM1
Gilead Sciences, Inc.GILD13PHASE3Sacituzumab Govitecan-hziy, Eribulin, Capecitabine Product, Gemcitabine, Vinorelbine
Novartis AG Sponsored ADRNVS30PHASE3Ribociclib
Pfizer Inc.PFE34PHASE3ARV-471, Fulvestrant
BeOne Medicines Ltd. Sponsored ADRONC5PHASE3BGB-43395, Letrozole, Abemaciclib, Palbociclib, Ribociclib
Olema Pharmaceuticals, Inc.OLMA5PHASE3Palazestrant, Fulvestrant, Anastrozole, Letrozole, Exemestane
Jazz Pharmaceuticals Public Limited CompanyJAZZ3PHASE3Zanidatamab, Trastuzumab, Eribulin, Vinorelbine, Gemcitabine
Celcuity Inc.CELC3PHASE3Gedatolisib, Palbociclib, Fulvestrant, Alpelisib
Relay Therapeutics, Inc.RLAY2PHASE3Zovegalisib, Capivasertib, Fulvestrant
GSK plc Sponsored ADRGSK2PHASE3Niraparib
Greenwich LifeSciences, Inc.GLSI1PHASE3GLSI-100
Bristol-Myers Squibb CompanyBMY5PHASE2Iza-bren, Nab-paclitaxel, Paclitaxel, Capecitabine, Carboplatin
BriaCell Therapeutics CorpBCTX2PHASE3SV-BR-1-GM, Cyclophosphamide, Interferon infiltration of the inoculation site, Retifanlimab, Treatment of Physician's Choice
Incyte CorporationINCY4PHASE2Ruxolitinib, Capecitabine, Regorafenib
Natera, Inc.NTRA3PHASE2Discontinuation of the anti-HER2 maintenance therapy
Puma Biotechnology, Inc.PBYI3PHASE2Neratinib, Loperamide, Colesevelam
Atossa Therapeutics, Inc.ATOS1PHASE2endoxifen, goserelin
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Frequently asked questions about ABT-751

What is ABT-751 used for?

ABT-751 is an investigational small molecule being studied in oncology for the treatment of breast cancer, non-small cell lung cancer, renal cell cancer, and colorectal cancer. It is being developed by Abbott Laboratories and is currently in Phase 2 clinical development.

Who makes ABT-751?

ABT-751 is being developed by Abbott Laboratories, a company traded on the New York Stock Exchange under the ticker symbol ABT. The drug is an investigational small molecule in Phase 2 clinical development for multiple cancer indications.

What phase is ABT-751 in?

ABT-751 is in Phase 2 clinical development. It is an investigational drug and has not been approved by the FDA. Clinical trials for the drug have been completed, and it is being studied for breast cancer, non-small cell lung cancer, renal cell cancer, and colorectal cancer.

What clinical trials is ABT-751 in?

ABT-751 has completed four Phase 2 clinical trials: NCT00063102 for recurrent breast cancer, NCT00073112 for renal cell cancer, NCT00073138 for colorectal cancer, and NCT00073151 for non-small cell lung cancer. These trials were conducted in the United States and Canada.

Is ABT-751 the same as any other drug?

ABT-751 is the primary name for this investigational drug. No alternative names have been reported for this compound. It is being developed by Abbott Laboratories for the treatment of several types of cancer.