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Enapotamab vedotin

Phase 2

Ovarian Cancer | Monoclonal antibody | Oncology |Genmab A/S|Last Updated: Jul 31, 2023

Success Probability

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment306

FDA Designations

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Clinical trial landscape

Enapotamab vedotin · 1 trial · 8 indications

Phase 1/2 1
NCT02988817Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid TumorsOvarian Cancer
COMPLETED306 Analytics
PHASE1/PHASE2COMPLETED
Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid Tumors
Ovarian CancerUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
Enapotamab vedotin (HuMax-AXL-ADC)BIOLOGICALEnapotamab vedotin (HuMax-AXL-ADC) will be administered intravenously.
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Competitive Landscape -Ovarian Cancer 176 trials

Top 20 of 59 competitors

CompanyTickerTrialsLead PhaseDrugs
Merck & Co., Inc.MRK5PHASE3Pembrolizumab, Paclitaxel, Bevacizumab, Docetaxel
AstraZeneca PLCAZN19PHASE3Olaparib
GSK plc Sponsored ADRGSK4PHASE3Niraparib
Eli Lilly and CompanyLLY8PHASE3Sofetabart Mipitecan, Paclitaxel, Topotecan, Gemcitabine, Pegylated liposomal doxorubicin
AbbVie, Inc.ABBV13PHASE3Mirvetuximab soravtansine plus Bevacizumab, Bevacizumab
Bristol-Myers Squibb CompanyBMY4PHASE3Rucaparib, Nivolumab
Genmab A/S Sponsored ADRGMAB5PHASE3Rina-S, Paclitaxel, Topotecan, Pegylated liposomal doxorubicin, Gemcitabine
Pfizer Inc.PFE4PHASE3Avelumab, Lorlatanib, Talazoparib, Pemetrexed, Axitinib
Corcept Therapeutics Incorporated.CORT2PHASE3Nab-paclitaxel/m^2, Relacorilant once daily
Verastem, Inc.VSTM4PHASE3avutometinib, Defactinib, Pegylated liposomal doxorubicin, Paclitaxel, Letrozole
Zentalis Pharmaceuticals, Inc.ZNTL3PHASE3Azenosertib
Imunon, Inc.IMNN3PHASE3IMNN-001, Paclitaxel, Carboplatin, Olaparib, Niraparib
Incyte CorporationINCY2PHASE3INCB123667
Genelux Corp.GNLX1PHASE3olvimulogene nanivacirepvec, Platinum chemotherapy: carboplatin or cisplatin, Non-platinum chemotherapy: Physician's Choice of gemcitabine, taxane or pegylated liposomal doxorubicin, Bevacizumab
Regeneron Pharmaceuticals, Inc.REGN4PHASE2Ubamatamab, Bevacizumab, Cemiplimab, Fianlimab, PLD
Novartis AG Sponsored ADRNVS4PHASE2Dabrafenib, Trametinib
BeOne Medicines Ltd. Sponsored ADRONC2PHASE3Pamiparib
IQVIA Holdings IncIQV1PHASE3Oregovomab, Paclitaxel, Carboplatin
Xencor, Inc.XNCR3PHASE2vudalimab
Exelixis, Inc.EXEL2PHASE2Cabozantinib
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Frequently asked questions about Enapotamab vedotin

What is Enapotamab vedotin used for?

Enapotamab vedotin is an investigational monoclonal antibody being studied for the treatment of ovarian cancer. It is currently in Phase 2 clinical development. The drug is being evaluated in oncology, specifically for patients with solid tumors, including ovarian cancer.

What does Enapotamab vedotin target?

Enapotamab vedotin is an antibody-drug conjugate that targets AXL, a receptor tyrosine kinase. It is designed to deliver a cytotoxic agent to AXL-expressing tumor cells. The drug is being developed by Genmab A/S for the treatment of ovarian cancer and other solid tumors.

Who makes Enapotamab vedotin?

Enapotamab vedotin is being developed by Genmab A/S, a biotechnology company. Genmab is publicly traded under the ticker symbol GMAB. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational drug in patients with solid tumors.

What phase is Enapotamab vedotin in?

Enapotamab vedotin is currently in Phase 2 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The drug is being studied for the treatment of ovarian cancer and other solid tumors.

What clinical trials is Enapotamab vedotin in?

Enapotamab vedotin has been studied in a clinical trial with the identifier NCT02988817. This trial, titled 'Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid Tumors,' was a Phase 1/Phase 2 study that has been completed. The trial enrolled 306 patients with various solid tumors, including ovarian cancer.

Is Enapotamab vedotin the same as HuMax-AXL-ADC?

Yes, Enapotamab vedotin is also known as HuMax-AXL-ADC. This alternative name was used in the clinical trial title for the safety study of the drug in patients with solid tumors. Both names refer to the same investigational antibody-drug conjugate being developed by Genmab.