Financials
Cash Data
- Monthly Burn
- Burn Trend
- Dilution Risk
- SEC Filing
Key Stats
Upcoming Catalysts
FDA decisions, readouts and PDUFA dates · scored by probability of approval
JAZZ Catalyst Timeline
Dated clinical, regulatory and corporate events for Jazz Pharmaceuticals plc
Catalyst Timeline
Dated clinical, regulatory & corporate events for Jazz Pharmaceuticals plc
Upcoming catalysts 2
Event history 50
Past FDA Catalysts and PDUFA Decisions
How JAZZ actually traded into and out of each decision
| Date | Drug | Catalyst | Stage | Reaction | Event Move % | Best Trade % |
|---|---|---|---|---|---|---|
| 2026-09-30 | Ziihera (zanidatamab-hrii) | Phase 3 topline data readout | Phase 3 |
Drug Pipeline Intelligence
| Product | Revenue | Prior period | Change |
|---|---|---|---|
| Xywav | $1.8B | $1.5B | +14.6% |
| Epidiolex/Epidyolex | $1.1B | $996M | +13.6% |
| Rylaze/Enrylaze | $411M | $395M | +4.1% |
| Zepzelca | $377M | $302M | +24.8% |
| Defitelio/defibrotide | $220M | $212M | +3.6% |
| Modeyso | $137M | - | - |
| Xyrem | $135M | $180M | -24.9% |
| Vyxeos | $130M | $162M | -19.5% |
| Ziihera | $46M | - | - |
| Drug | Indication | Phase | PTRS | rNPV | Status | Enroll | Velocity | Design | Est. Completion | ML Signal | Last Change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| GWP42004 Small moleculeCompletedNCT02053272 | Diabetes Mellitus, Type 2 | Phase 2 | COMPLETED | 207 | Feb 1, 2016 |
Clinical Trial Results
Readouts, endpoints and source filings for every JAZZ program
| Drug Name | Indication | Phase | Date | Trial Results Summary | Title | Source |
|---|---|---|---|---|---|---|
| Ziihera BreakthroughPriority | HER2+ gastroesophageal adenocarcinoma | Phase 3 | 2026-08-31 | statistically significant and clinically meaningful improvements in OS compared with trastuzumab plus chemotherapyRead More | Ziihera® (zanidatamab-hrii) plus Chemotherapy Demonstrates Statistically Significant Overall Survival Benefit Versus Trastuzumab plus Chemotherapy in First-Line HER2+ Advanced GEA Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced second interim top-line overall survival (OS) results from the Phase 3 HERIZON-GEA-01 trial...Read More |
Inside Trades
| Insider | Side | Shares | Price | Value | Date |
|---|---|---|---|---|---|
| GALA RENEE DDirector, Officer (President & CEO) | Sell | -2,000 141,394 held | $236.40 | 10/06/2026 |
Hedge Fund 13F Activity
Hedge Funds invested in JAZZ
| Fund | % of Portfolio | Current MV | Shares Owned | Activity |
|---|---|---|---|---|
| Sofinnova Investments, Inc. | 4.6 % (7 %) | 88.04 M | 365.34 K | -38.94% ( -232.99 K) |
JAZZ Institutional Ownership Trends
Options Data
Option Volume
Option Chain Statistics
| Expiry | Call Vol | Put Vol | Vol P/C | Call OI | Put OI | OI P/C | IV Call | IV Call OI-Wtd | IV Call Vol-Wtd | IV Put | IV Put OI-Wtd | IV Put Vol-Wtd |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-11-20 | ||||||||||||
Real-Time Option Chain
| Calls | Strike | Puts | ||||
|---|---|---|---|---|---|---|
| Last | Vol | OI | Last | Vol | OI | |
| No data available | ||||||
Calls vs Puts by Expiry
Competitive positioning
How JAZZ ranks across every disease it competes in
JAZZ News
Jazz Pharmaceuticals Completes Acquisition of Actio Biosciences
Jazz Pharmaceuticals has successfully acquired Actio Biosciences for $820 million, enhancing its epilepsy pipeline with the addition of ABS-1230, a potential first-in-class therapy for KCNT1-related epilepsy. ABS-1230 has shown promising results in early trials, indicating significant seizure reductions in children. The acquisition aims to leverage Actio's precision biology expertise alongside Jazz's development capabilities.
Read more →Jazz Pharmaceuticals to Participate in Upcoming Investor Conferences
Jazz Pharmaceuticals has announced its participation in several upcoming investor conferences, including the Wells Fargo 21st Annual Healthcare Conference and the Citi 2026 Biopharma Back to School Summit. Management will engage in fireside chats to discuss the company's developments. Audio webcasts of these events will be available on their website.
Read more →Ziihera® (zanidatamab-hrii) plus Chemotherapy Demonstrates Statistically Significant Overall Survival Benefit Versus Trastuzumab plus Chemotherapy in First-Line HER2+ Advanced GEA
Jazz Pharmaceuticals announced positive interim results from the Phase 3 HERIZON-GEA-01 trial, showing that Ziihera (zanidatamab-hrii) combined with chemotherapy significantly improves overall survival compared to trastuzumab plus chemotherapy for HER2+ gastroesophageal adenocarcinoma. The FDA recently approved Ziihera for first-line treatment, reinforcing its role as a new standard of care. The safety profile remains consistent with prior studies.
Read more →Jazz Pharmaceuticals Announces Pricing of Upsized Private Offering of $1.1 Billion of 1.875% Exchangeable Senior Notes due 2032 and Concurrent Ordinary Share Repurchases
Jazz Pharmaceuticals has announced the pricing of an upsized $1.1 billion offering of 1.875% exchangeable senior notes due 2032. The offering, which includes an option for additional notes, is expected to close on August 31, 2026. Concurrently, the company plans to repurchase approximately $225 million of its ordinary shares. The proceeds from the notes will be used for general corporate purposes.
Read more →Jazz Pharmaceuticals Announces Private Offering of $1.0 Billion of Exchangeable Senior Notes due 2032 and Concurrent Ordinary Share Repurchases
Jazz Pharmaceuticals has announced a private offering of $1.0 billion in exchangeable senior notes due 2032, aimed at qualified institutional buyers. The company will also repurchase up to $225 million of its ordinary shares concurrently with the offering. The proceeds from the offering are intended for general corporate purposes, although market conditions may affect the transaction.
Read more →U.S. FDA Approves Ziihera® (zanidatamab-hrii) with and without Tislelizumab plus Chemotherapy in First-Line HER2+ Advanced Gastroesophageal Adenocarcinoma
Jazz Pharmaceuticals announced FDA approval for Ziihera (zanidatamab-hrii) in combination with tislelizumab and chemotherapy for first-line treatment of advanced HER2-positive gastroesophageal adenocarcinoma. This approval establishes a new standard of care and is based on the HERIZON-GEA-01 trial results, which demonstrated significant improvements in overall and progression-free survival. The approval is significant for patients with limited treatment options.
Read more →Jazz Pharmaceuticals to Acquire Actio Biosciences, Expanding Rare Epilepsy Portfolio
Jazz Pharmaceuticals has announced its acquisition of Actio Biosciences for $820 million upfront, with potential additional payments of up to $500 million. This acquisition includes ABS-1230, a novel therapy for KCNT1+ epilepsy, a rare condition with no current FDA-approved treatments. The deal is expected to close in the fourth quarter of 2026, pending customary conditions.
Read more →Jazz Pharmaceuticals Announces Second Quarter 2026 Financial Results
Jazz Pharmaceuticals reported strong financial results for the second quarter of 2026, achieving record revenues of $1.2 billion, a 16% increase year-over-year. The company raised its revenue guidance for the year, anticipating continued growth driven by its key products, including Xywav and Epidiolex. Additionally, Jazz is preparing to launch its new drug Ziihera pending FDA approval.
Read more →Jazz Pharmaceuticals to Report Second Quarter Financial Results on August 3, 2026
Jazz Pharmaceuticals has announced that it will report its second quarter financial results on August 3, 2026. The report will be released after the U.S. financial markets close, followed by a management-hosted webcast at 4:30 p.m. ET. Interested parties can register in advance for the call and access a replay via the company's website.
Read more →Jazz Pharmaceuticals and AbCellera Announce Collaboration to Discover Next-Generation T-cell Engaging Multispecific Antibodies Jazz Pharmaceuticals plc (Nasdaq: JAZZ) and AbCellera (Nasdaq: ABCL) today announced a preclinical research collaboration, option and license...
Jazz Pharmaceuticals and AbCellera have announced a preclinical collaboration to develop T-cell engaging multispecific antibodies targeted at gastrointestinal cancers and other solid tumors. The agreement includes $56 million in upfront payments and up to $792 million in potential milestone payments. Jazz has the exclusive option to develop any therapeutic antibodies that result from the collaboration, further enhancing its oncology portfolio. This partnership is expected to leverage AbCellera's advanced antibody discovery capabilities to provide novel treatment options for difficult-to-treat cancers.
Read more →Jazz Pharmaceuticals Delivers Extensive Late-Breaking Data at SLEEP 2026, Demonstrating Real-World Impact of Xywav® (calcium, magnesium, potassium, and sodium oxybates) on Patient Outcomes Across Narcolepsy and Idiopathic Hypersomnia Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced 11 late-breaking presentations at SLEEP 2026, including notable new research showcasing the...
Jazz Pharmaceuticals showcased 11 late-breaking presentations at SLEEP 2026, highlighting the efficacy of Xywav in treating narcolepsy and idiopathic hypersomnia. The research emphasizes the importance of individualized dosing and potential cardiometabolic health benefits associated with Xywav's low-sodium formulation. Findings suggest meaningful health improvements for patients, establishing a comprehensive treatment paradigm that enhances patient quality of life. The data advances scientific understanding of complex sleep disorders, marking a significant milestone for Jazz Pharmaceuticals.
Read more →Jazz Pharmaceuticals Provides Update on Zepzelca® (lurbinectedin) Phase 3 LAGOON Trial in Second-Line Small Cell Lung Cancer
Jazz Pharmaceuticals announced that the Phase 3 LAGOON trial for Zepzelca (lurbinectedin) in second-line small cell lung cancer did not meet its primary endpoint of overall survival. Despite this, the safety profile remained consistent with previous data. The company plans to discuss the results with the FDA regarding post-marketing requirements for the second-line indication.
Read more →Jazz Pharmaceuticals to Present Comprehensive Data at SLEEP 2026 Highlighting Broad Treatment Effects of Xywav® (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for People with Narcolepsy and Idiopathic Hypersomnia Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the company will present 21 abstracts, including 11 late-breaking abstracts, at SLEEP...
Jazz Pharmaceuticals announced that they will present 21 abstracts, including 11 late-breaking ones, at SLEEP 2026, showcasing ongoing research into the treatment of narcolepsy and idiopathic hypersomnia. The data emphasizes the effectiveness of their product, Xywav, which is the first FDA-approved treatment for idiopathic hypersomnia. This substantial presentation underscores the company's dedication to addressing challenging sleep disorders through clinical research and real-world evidence.
Read more →Phase 3 HERIZON-GEA-01 Results Published in The New England Journal of Medicine Show Durable and Consistent Survival Benefit with Ziihera® (zanidatamab-hrii) Combinations in First-Line HER2+ Locally Advanced or Metastatic GEA Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the New England Journal of Medicine has published the Phase 3 HERIZON-GEA-01 trial...
Jazz Pharmaceuticals announced the publication of Phase 3 HERIZON-GEA-01 trial results in the New England Journal of Medicine, which showcase the efficacy and safety of Ziihera (zanidatamab-hrii). The trial demonstrated significant improvements in progression-free survival and overall survival outcomes in patients with HER2-positive locally advanced or metastatic gastroesophageal adenocarcinoma. Additional analyses revealed consistent benefits across different PD-L1 expression levels, reinforcing zanidatamab's clinical potential. The findings could reshape first-line treatment expectations for this cancer indication.
Read more →Jazz Pharmaceuticals Announces First Quarter 2026 Financial ResultsUSA - EnglishUSA - English
Jazz Pharmaceuticals reported a strong financial performance for Q1 2026, achieving total revenues of $1.1 billion, a 19% increase year-over-year. The company highlighted significant growth in its product lines, particularly Xywav and Epidiolex, and announced that zanidatamab's supplemental Biologics License Application was granted Priority Review. Despite a GAAP net loss due to litigation expenses, Jazz reaffirmed its revenue guidance for 2026.
Read more →Jazz Pharmaceuticals Announces First Quarter 2026 Financial Results
Jazz Pharmaceuticals reported strong financial results for the first quarter of 2026, with total revenues reaching $1.1 billion, a 19% increase year-over-year. The company highlighted significant growth in its Xywav and Epidiolex products, alongside advancements in its pipeline, particularly with zanidatamab, which has been granted Priority Review by the FDA. The company remains optimistic about its financial guidance for the year, supported by strong commercial execution.
Read more →Jazz Pharmaceuticals Announces FDA Acceptance and Priority Review of Supplemental Biologics License Application for Ziihera® (zanidatamab-hrii) Combinations in First-Line HER2+ Locally Advanced or Metastatic GEA
Jazz Pharmaceuticals announced the FDA's acceptance of the supplemental Biologics License Application for zanidatamab in combination therapies for HER2-positive gastroesophageal adenocarcinoma. The application is supported by data from the HERIZON-GEA-01 trial, which demonstrated significant clinical benefits. The FDA has set a target action date of August 25, 2026, for the review.
Read more →Jazz Pharmaceuticals to Report First Quarter Financial Results on May 5, 2026
Jazz Pharmaceuticals has announced it will release its first quarter financial results for 2026 on May 5, 2026. The results will be shared after the U.S. markets close, followed by a webcast hosted by company management. This event will provide insights into the company's business and financial status.
Read more →Jazz Pharmaceuticals to Present Data at ASCO 2026 Highlighting Advancements for Ziihera® (zanidatamab-hrii) in Gastroesophageal Adenocarcinoma and Zepzelca® (lurbinectedin) Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the Company and its partners will present three rapid oral and seven poster...
Jazz Pharmaceuticals plc announced its participation in the upcoming ASCO 2026 Annual Meeting, where it will present multiple studies related to zanidatamab and lurbinectedin. The key presentations will focus on zanidatamab's performance in advanced HER2-positive gastroesophageal adenocarcinoma and real-world data on the safety and effectiveness of lurbinectedin in extensive-stage small cell lung cancer. This initiative highlights Jazz's commitment to advancing treatment options through innovative research and collaboration.
Read more →