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Jazz Pharmaceuticals plc

JAZZ
UndervaluedPharma · Commercial
FDA catalysts, PDUFA dates & pipeline intelligence
$218.42
▼ -4.03 · -1.81%

Financials

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52W LOW $128.8052W HIGH $266.38
Volume
1.29 M
Value Traded
230.73 M
Short % Float
7.5%
-7.46%Week
-11.14%1 Month
-7.83%3 Month
+11.83%6 Month
+33.83%5 Year
+1,270.46%All Time

Cash Data

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Key Stats

Market Cap
14.18 B
EPS (TTM)
14.49
P/E Ratio
15.07
Ent. Value
17.35 B
Total Shares
64.89 M
Float Shares
62.35 M
Insiders
3.95%
Institutions
99.93%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
Phase 3 data presentation
Ziihera (zanidatamab-hrii) plus Tevimbra (tislelizumab-jsgr) and chemotherapy
HER2-positive locally advanced or metastatic gastroesophageal adenocarcinoma (GEA)
Fast TrackOrphan
Phase 3BiologicsOncology
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

JAZZ Catalyst Timeline

Dated clinical, regulatory and corporate events for Jazz Pharmaceuticals plc

Catalyst Timeline

Dated clinical, regulatory & corporate events for Jazz Pharmaceuticals plc

1209Total events
14Upcoming
346Tier-1 (high impact)
2012 to 2030Coverage

Upcoming catalysts 2

T1Acquisition
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T2Oral Presentation
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ZanidatamabApproved

Event history 50

▲AcquiredCorporate
Jazz completes acquisition of Actio Biosciences for $820 million upfront
●Partnership / LicenseCorporate
Actio spun out new private entity holding non-ABS-1230 programs; Jazz received minority stake and related rights
▲Topline ReadoutZanidatamabApprovedClinical Data
Second interim top-line OS results from HERIZON-GEA-01
HER2-positive locally advanced or metastatic gastroesophageal adenocarcinoma (GEA)source ↗
●Debt Royalty FinancingCorporate
Pricing of $1.1 billion 1.875% exchangeable senior notes due 2032
●Equity OfferingCorporate
Concurrent ordinary share repurchases of approximately $225.0 million
◆Debt Royalty FinancingCorporate
Private offering of $1.0 billion exchangeable senior notes due 2032
◆ATM ProgramCorporate
Concurrent ordinary share repurchases up to $225.0 million
▲FDA ApprovalZanidatamabApprovedFDA Decision
FDA approved Ziihera in combination with tislelizumab and chemotherapy for first-line HER2+ GEA
first-line treatment of adults with HER2+ (IHC 3+ and IHC 2+/ISH+) unresectable locally advanced or metastatic GEA, and Ziihera in combination with chemotherapy in the same setting for patients with HER2+ (IHC 3+) diseasesource ↗
●Oral PresentationZanidatamabApprovedPresentation
Investor webcast to discuss FDA approval and zanidatamab program updates
HER2+ advanced gastroesophageal adenocarcinomasource ↗
◆AcquisitionCorporate
Jazz to acquire Actio Biosciences for $820M upfront
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Past FDA Catalysts and PDUFA Decisions

How JAZZ actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-09-30Ziihera (zanidatamab-hrii) Phase 3 topline data readout Phase 3
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

B77 / 100
Pipeline Score
$12.9B
Pipeline Value
$18.5B
Commercial Value
Undervalued
Valuation Signal
30
Drugs Scored
3.0x
rNPV / MCap
Top 3%
Mid Cap
(rank 21 of 660)
Percentile Rank
Jazz Pharmaceuticals plc holds a solid B-grade pipeline (77/100), with $15.1B risk-adjusted pipeline value, led by GWP42004 in Diabetes Mellitus, Type 2 (Phase 2).
Commercial products (revenue basis: trailing 4 quarters of total revenue (10-K and 10-Q), to Jun 2026; product lines: last four quarters to Jun 2026 (10-K and 10-Q)) Revenue $4.6B x 4.0 = $18.5B
ProductRevenuePrior periodChange
Xywav$1.8B$1.5B+14.6%
Epidiolex/Epidyolex$1.1B$996M+13.6%
Rylaze/Enrylaze$411M$395M+4.1%
Zepzelca$377M$302M+24.8%
Defitelio/defibrotide$220M$212M+3.6%
Modeyso$137M--
Xyrem$135M$180M-24.9%
Vyxeos$130M$162M-19.5%
Ziihera$46M--
Showing 1 of 30 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
GWP42004 Small moleculeCompletedNCT02053272Diabetes Mellitus, Type 2Phase 2 COMPLETED 207Feb 1, 2016
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Clinical Trial Results

Readouts, endpoints and source filings for every JAZZ program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
Ziihera
BreakthroughPriority
HER2+ gastroesophageal adenocarcinomaPhase 32026-08-31statistically significant and clinically meaningful improvements in OS compared with trastuzumab plus chemotherapyRead MoreZiihera® (zanidatamab-hrii) plus Chemotherapy Demonstrates Statistically Significant Overall Survival Benefit Versus Trastuzumab plus Chemotherapy in First-Line HER2+ Advanced GEA Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced second interim top-line overall survival (OS) results from the Phase 3 HERIZON-GEA-01 trial...Read More
Scroll for more · summaries link to the source press release
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Inside Trades

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InsiderSideSharesPriceValueDate
GALA RENEE DDirector, Officer (President & CEO)Sell -2,000 141,394 held$236.40 10/06/2026
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
Sofinnova Investments, Inc. 4.6 % (7 %) 88.04 M 365.34 K -38.94% ( -232.99 K)
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JAZZ Institutional Ownership Trends

Options Data

Option Volume

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Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
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Put-Call Ratio
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Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2026-11-20
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Real-Time Option Chain

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LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

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Competitive positioning

How JAZZ ranks across every disease it competes in

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See how JAZZ ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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JAZZ News

JAZZ
Sep 15, 2026
JAZZGeneral

Jazz Pharmaceuticals Completes Acquisition of Actio Biosciences

Jazz Pharmaceuticals has successfully acquired Actio Biosciences for $820 million, enhancing its epilepsy pipeline with the addition of ABS-1230, a potential first-in-class therapy for KCNT1-related epilepsy. ABS-1230 has shown promising results in early trials, indicating significant seizure reductions in children. The acquisition aims to leverage Actio's precision biology expertise alongside Jazz's development capabilities.

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JAZZ
Sep 2, 2026
JAZZConferences/Events

Jazz Pharmaceuticals to Participate in Upcoming Investor Conferences

Jazz Pharmaceuticals has announced its participation in several upcoming investor conferences, including the Wells Fargo 21st Annual Healthcare Conference and the Citi 2026 Biopharma Back to School Summit. Management will engage in fireside chats to discuss the company's developments. Audio webcasts of these events will be available on their website.

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JAZZ
Aug 31, 2026
JAZZPhases

Ziihera® (zanidatamab-hrii) plus Chemotherapy Demonstrates Statistically Significant Overall Survival Benefit Versus Trastuzumab plus Chemotherapy in First-Line HER2+ Advanced GEA

Jazz Pharmaceuticals announced positive interim results from the Phase 3 HERIZON-GEA-01 trial, showing that Ziihera (zanidatamab-hrii) combined with chemotherapy significantly improves overall survival compared to trastuzumab plus chemotherapy for HER2+ gastroesophageal adenocarcinoma. The FDA recently approved Ziihera for first-line treatment, reinforcing its role as a new standard of care. The safety profile remains consistent with prior studies.

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JAZZ
Aug 27, 2026
JAZZGeneral

Jazz Pharmaceuticals Announces Pricing of Upsized Private Offering of $1.1 Billion of 1.875% Exchangeable Senior Notes due 2032 and Concurrent Ordinary Share Repurchases

Jazz Pharmaceuticals has announced the pricing of an upsized $1.1 billion offering of 1.875% exchangeable senior notes due 2032. The offering, which includes an option for additional notes, is expected to close on August 31, 2026. Concurrently, the company plans to repurchase approximately $225 million of its ordinary shares. The proceeds from the notes will be used for general corporate purposes.

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JAZZ
Aug 26, 2026
JAZZGeneral

Jazz Pharmaceuticals Announces Private Offering of $1.0 Billion of Exchangeable Senior Notes due 2032 and Concurrent Ordinary Share Repurchases

Jazz Pharmaceuticals has announced a private offering of $1.0 billion in exchangeable senior notes due 2032, aimed at qualified institutional buyers. The company will also repurchase up to $225 million of its ordinary shares concurrently with the offering. The proceeds from the offering are intended for general corporate purposes, although market conditions may affect the transaction.

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JAZZ
Aug 25, 2026
JAZZFDA Updates

U.S. FDA Approves Ziihera® (zanidatamab-hrii) with and without Tislelizumab plus Chemotherapy in First-Line HER2+ Advanced Gastroesophageal Adenocarcinoma

Jazz Pharmaceuticals announced FDA approval for Ziihera (zanidatamab-hrii) in combination with tislelizumab and chemotherapy for first-line treatment of advanced HER2-positive gastroesophageal adenocarcinoma. This approval establishes a new standard of care and is based on the HERIZON-GEA-01 trial results, which demonstrated significant improvements in overall and progression-free survival. The approval is significant for patients with limited treatment options.

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JAZZ
Aug 10, 2026
JAZZGeneral

Jazz Pharmaceuticals to Acquire Actio Biosciences, Expanding Rare Epilepsy Portfolio

Jazz Pharmaceuticals has announced its acquisition of Actio Biosciences for $820 million upfront, with potential additional payments of up to $500 million. This acquisition includes ABS-1230, a novel therapy for KCNT1+ epilepsy, a rare condition with no current FDA-approved treatments. The deal is expected to close in the fourth quarter of 2026, pending customary conditions.

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JAZZ
Aug 3, 2026
JAZZGeneral

Jazz Pharmaceuticals Announces Second Quarter 2026 Financial Results

Jazz Pharmaceuticals reported strong financial results for the second quarter of 2026, achieving record revenues of $1.2 billion, a 16% increase year-over-year. The company raised its revenue guidance for the year, anticipating continued growth driven by its key products, including Xywav and Epidiolex. Additionally, Jazz is preparing to launch its new drug Ziihera pending FDA approval.

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JAZZ
Jul 20, 2026
JAZZConferences/Events

Jazz Pharmaceuticals to Report Second Quarter Financial Results on August 3, 2026

Jazz Pharmaceuticals has announced that it will report its second quarter financial results on August 3, 2026. The report will be released after the U.S. financial markets close, followed by a management-hosted webcast at 4:30 p.m. ET. Interested parties can register in advance for the call and access a replay via the company's website.

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JAZZ
Jun 17, 2026
JAZZGeneral

Jazz Pharmaceuticals and AbCellera Announce Collaboration to Discover Next-Generation T-cell Engaging Multispecific Antibodies Jazz Pharmaceuticals plc (Nasdaq: JAZZ) and AbCellera (Nasdaq: ABCL) today announced a preclinical research collaboration, option and license...

Jazz Pharmaceuticals and AbCellera have announced a preclinical collaboration to develop T-cell engaging multispecific antibodies targeted at gastrointestinal cancers and other solid tumors. The agreement includes $56 million in upfront payments and up to $792 million in potential milestone payments. Jazz has the exclusive option to develop any therapeutic antibodies that result from the collaboration, further enhancing its oncology portfolio. This partnership is expected to leverage AbCellera's advanced antibody discovery capabilities to provide novel treatment options for difficult-to-treat cancers.

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JAZZ
Jun 16, 2026
JAZZConferences/Events

Jazz Pharmaceuticals Delivers Extensive Late-Breaking Data at SLEEP 2026, Demonstrating Real-World Impact of Xywav® (calcium, magnesium, potassium, and sodium oxybates) on Patient Outcomes Across Narcolepsy and Idiopathic Hypersomnia Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced 11 late-breaking presentations at SLEEP 2026, including notable new research showcasing the...

Jazz Pharmaceuticals showcased 11 late-breaking presentations at SLEEP 2026, highlighting the efficacy of Xywav in treating narcolepsy and idiopathic hypersomnia. The research emphasizes the importance of individualized dosing and potential cardiometabolic health benefits associated with Xywav's low-sodium formulation. Findings suggest meaningful health improvements for patients, establishing a comprehensive treatment paradigm that enhances patient quality of life. The data advances scientific understanding of complex sleep disorders, marking a significant milestone for Jazz Pharmaceuticals.

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JAZZ
Jun 12, 2026
JAZZPhases

Jazz Pharmaceuticals Provides Update on Zepzelca® (lurbinectedin) Phase 3 LAGOON Trial in Second-Line Small Cell Lung Cancer

Jazz Pharmaceuticals announced that the Phase 3 LAGOON trial for Zepzelca (lurbinectedin) in second-line small cell lung cancer did not meet its primary endpoint of overall survival. Despite this, the safety profile remained consistent with previous data. The company plans to discuss the results with the FDA regarding post-marketing requirements for the second-line indication.

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JAZZ
Jun 4, 2026
JAZZConferences/Events

Jazz Pharmaceuticals to Present Comprehensive Data at SLEEP 2026 Highlighting Broad Treatment Effects of Xywav® (calcium, magnesium, potassium, and sodium oxybates) Oral Solution for People with Narcolepsy and Idiopathic Hypersomnia Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the company will present 21 abstracts, including 11 late-breaking abstracts, at SLEEP...

Jazz Pharmaceuticals announced that they will present 21 abstracts, including 11 late-breaking ones, at SLEEP 2026, showcasing ongoing research into the treatment of narcolepsy and idiopathic hypersomnia. The data emphasizes the effectiveness of their product, Xywav, which is the first FDA-approved treatment for idiopathic hypersomnia. This substantial presentation underscores the company's dedication to addressing challenging sleep disorders through clinical research and real-world evidence.

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JAZZ
May 27, 2026
JAZZPhases

Phase 3 HERIZON-GEA-01 Results Published in The New England Journal of Medicine Show Durable and Consistent Survival Benefit with Ziihera® (zanidatamab-hrii) Combinations in First-Line HER2+ Locally Advanced or Metastatic GEA Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the New England Journal of Medicine has published the Phase 3 HERIZON-GEA-01 trial...

Jazz Pharmaceuticals announced the publication of Phase 3 HERIZON-GEA-01 trial results in the New England Journal of Medicine, which showcase the efficacy and safety of Ziihera (zanidatamab-hrii). The trial demonstrated significant improvements in progression-free survival and overall survival outcomes in patients with HER2-positive locally advanced or metastatic gastroesophageal adenocarcinoma. Additional analyses revealed consistent benefits across different PD-L1 expression levels, reinforcing zanidatamab's clinical potential. The findings could reshape first-line treatment expectations for this cancer indication.

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JAZZ
May 5, 2026
JAZZGeneral
▲ +7.7%on this news

Jazz Pharmaceuticals Announces First Quarter 2026 Financial ResultsUSA - EnglishUSA - English

Jazz Pharmaceuticals reported a strong financial performance for Q1 2026, achieving total revenues of $1.1 billion, a 19% increase year-over-year. The company highlighted significant growth in its product lines, particularly Xywav and Epidiolex, and announced that zanidatamab's supplemental Biologics License Application was granted Priority Review. Despite a GAAP net loss due to litigation expenses, Jazz reaffirmed its revenue guidance for 2026.

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JAZZ
May 5, 2026
JAZZGeneral

Jazz Pharmaceuticals Announces First Quarter 2026 Financial Results

Jazz Pharmaceuticals reported strong financial results for the first quarter of 2026, with total revenues reaching $1.1 billion, a 19% increase year-over-year. The company highlighted significant growth in its Xywav and Epidiolex products, alongside advancements in its pipeline, particularly with zanidatamab, which has been granted Priority Review by the FDA. The company remains optimistic about its financial guidance for the year, supported by strong commercial execution.

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JAZZ
Apr 27, 2026
JAZZFDA Updates

Jazz Pharmaceuticals Announces FDA Acceptance and Priority Review of Supplemental Biologics License Application for Ziihera® (zanidatamab-hrii) Combinations in First-Line HER2+ Locally Advanced or Metastatic GEA

Jazz Pharmaceuticals announced the FDA's acceptance of the supplemental Biologics License Application for zanidatamab in combination therapies for HER2-positive gastroesophageal adenocarcinoma. The application is supported by data from the HERIZON-GEA-01 trial, which demonstrated significant clinical benefits. The FDA has set a target action date of August 25, 2026, for the review.

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JAZZ
Apr 21, 2026
JAZZConferences/Events

Jazz Pharmaceuticals to Report First Quarter Financial Results on May 5, 2026

Jazz Pharmaceuticals has announced it will release its first quarter financial results for 2026 on May 5, 2026. The results will be shared after the U.S. markets close, followed by a webcast hosted by company management. This event will provide insights into the company's business and financial status.

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JAZZ
Apr 21, 2026
JAZZConferences/Events

Jazz Pharmaceuticals to Present Data at ASCO 2026 Highlighting Advancements for Ziihera® (zanidatamab-hrii) in Gastroesophageal Adenocarcinoma and Zepzelca® (lurbinectedin) Jazz Pharmaceuticals plc (Nasdaq: JAZZ) today announced that the Company and its partners will present three rapid oral and seven poster...

Jazz Pharmaceuticals plc announced its participation in the upcoming ASCO 2026 Annual Meeting, where it will present multiple studies related to zanidatamab and lurbinectedin. The key presentations will focus on zanidatamab's performance in advanced HER2-positive gastroesophageal adenocarcinoma and real-world data on the safety and effectiveness of lurbinectedin in extensive-stage small cell lung cancer. This initiative highlights Jazz's commitment to advancing treatment options through innovative research and collaboration.

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About Jazz Pharmaceuticals plc

Waterloo Exchange, DUBLIN 2,890 employees jazzpharmaceuticals.com
HeadquartersFIFTH FLOOR, WATERLOO EXCHANGE, DUBLIN, D04 E5W7
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