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AstraZeneca PLC

AZN
Fair ValuePharma · Commercial
FDA catalysts, PDUFA dates & pipeline intelligence
$159.2
▲ +0.42 · +0.26%

Financials

Last updated
Revenue
R&D Expenses
Operating CF
Total Assets
Total Liabilities
Equity
Shares Out.
D/E Ratio
Quarterly Cash
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52W LOW $153.4152W HIGH $212.71
Volume
2.12 M
Value Traded
605.23 M
Short % Float
0.14%
+1.71%Week
-0.28%1 Month
-6.06%3 Month
-21.28%6 Month
+64.22%5 Year
+368.75%All Time

Cash Data

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  • SEC Filing

Key Stats

Market Cap
246.90 B
EPS (TTM)
6.61
P/E Ratio
24.09
Ent. Value
301.56 B
Total Shares
1.55 B
Float Shares
1.50 B
Insiders
3.44%
Institutions
60.85%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
PDUFA
2026
Example Drug
Treatment for example condition requiring FDA review
Phase 3Small MoleculeOncology-
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

AZN Catalyst Timeline

Dated clinical, regulatory and corporate events for AstraZeneca PLC

Catalyst Timeline

Dated clinical, regulatory & corporate events for AstraZeneca PLC

150Total events
14Upcoming
108Tier-1 (high impact)
2015 to 2026Coverage

Upcoming catalysts 2

T2Product Launch
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ZEGFROVYApproved
T2Timing Guidance
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Event history 50

▲Manufacturing MilestoneCMC / Inspection
AstraZeneca opens new global strategic R&D center in Kendall Square, Cambridge, Massachusetts
▲Partnership / LicenseCorporate
Daiichi Sankyo and AstraZeneca enter clinical trial collaboration with Summit Therapeutics to evaluate Datroway plus ivonescimab
multiple tumor types including lung and breast cancerssource ↗
▲Milestone PaymentElecoglipronCorporate
Eccogene receives $50M milestone payment from AstraZeneca
▲Partnership / LicenseCorporate
Susan G. Komen and AstraZeneca announce Navigation Infrastructure Collaboration partnership
breast cancersource ↗
▲Partnership / LicenseZEGFROVYApprovedCorporate
AstraZeneca completes global license agreement with Dizal for ZEGFROVY (sunvozertinib)
lung cancersource ↗
▲Trial InitiationElecoglipronTrial
Initiation of Elevate Phase 3 outcome trials of elecoglipron in HFmrEF/HFpEF and CKD
heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and chronic kidney disease (CKD)source ↗
▲FDA ApprovalCamizestrantApprovedFDA Decision
AstraZeneca's camizestrant in combination with CDK 4/6 inhibitor approved in the US
HR+, HER2–, locally advanced or metastatic breast cancer upon detection of ESR1 mutationsource ↗
▲FDA ApprovalLEROCHOLApprovedFDA Decision
FDA approved autoinjector for LEROCHOL and updated prescribing information
reducing risk of major adverse cardiovascular events (MACE) in adults through LDL-C loweringsource ↗
▲Quarterly UpdateCorporate
AstraZeneca reported H1 and Q2 2026 financial results
▲Partnership / LicenseZEGFROVYApprovedCorporate
Dizal grants AstraZeneca global exclusive license for Zegfrovy
non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutationssource ↗
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Past FDA Catalysts and PDUFA Decisions

How AZN actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-09-16Truqap (capivasertib) PDUFA Date ApprovedPDUFA
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

A84 / 100
Pipeline Score
$85.8B
Pipeline Value
$262.6B
Commercial Value
Fair Value
Valuation Signal
237
Drugs Scored
1.2x
rNPV / MCap
Top 1%
Large Pharma
(rank 8 of 660)
Percentile Rank
AstraZeneca PLC earns an A-grade pipeline score (84/100), with $85.9B risk-adjusted pipeline value, led by Elecoglipron in Type 2 Diabetes Mellitus (Phase 3).
Commercial products (revenue basis: trailing 4 quarters of total revenue (20-F and 6-K), to Jun 2026; product lines: last four quarters to Jun 2026 (20-F and 6-K)) Revenue $61.4B x 4.3 = $262.6B
ProductRevenuePrior periodChange
Farxiga$8.2B--
Tagrisso$7.5B--
Imfinzi$6.9B--
Ultomiris$5.1B--
Calquence$3.8B--
Lynparza$3.3B--
Symbicort$2.9B--
Fasenra$2.1B--
Strensiq$2.0B--
Soliris$1.6B--
Breztri$1.3B--
Crestor$1.3B--
Top 12 of 30 product lines shown.
Showing 1 of 237 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
Elecoglipron Small moleculeNCT07662044Type 2 Diabetes MellitusPhase 3 RECRUITING 5,500Jul 14, 2028
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Clinical Trial Results

Readouts, endpoints and source filings for every AZN program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
BREZTRI uncontrolled asthmaPhase 32026-02-13BREZTRI improved lung function by 76mL (95% CI 57-94 mL, unadjusted p<0.001, as measured by morning pre-dose trough FEV1 over 24 weeks); 90mL (95% CI 72-108 mL, unadjusted p<0.001, as measured by FEV1 AUC0-3 over 24 weeks)Read MorePositive and clinically meaningful results from the Phase III KALOS and LOGOS trials for BREZTRI in patients with uncontrolled asthma published in The Lancet Respiratory MedicineRead More
Scroll for more · summaries link to the source press release
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Inside Trades

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Monthly insider buys and sells against the stock price, with the insider sentiment reading.
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InsiderSideSharesPriceValueDate
Sharma ManiOfficer (See Remarks)Buy 20.233 19,287.699 held$160.57 08/08/2026
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
ORBIMED ADVISORS LLC 3.2 % (23.1 %) 171.08 M 915.70 K 36.63% ( 245.50 K)
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Shares held by hedge funds each quarter, and who bought or sold.

AZN Institutional Ownership Trends

Options Data

Option Volume

Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg

Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2027-03-19
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Real-Time Option Chain

CallsStrikePuts
LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

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Competitive positioning

How AZN ranks across every disease it competes in

Competitive Position is a premium feature
See how AZN ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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AZN News

AZN
Oct 5, 2026
AZNGeneral

AstraZeneca opens new global strategic R&D center in Kendall Square, Cambridge, Massachusetts

AstraZeneca has inaugurated a new global strategic R&D center in Kendall Square, Cambridge, Massachusetts. This facility strengthens the company's existing presence in the area and aims to foster innovation by placing scientists in a leading life sciences ecosystem. The center is expected to enhance collaboration in genomic medicine and other research areas.

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AZN
Oct 5, 2026
AZNFDA Updates

SERD Market Set for Growth During the Forecast Period (2026-2036) as AstraZeneca's ETCAMAH Approval Accelerates Adoption of Oral SERDs | DelveInsight

The SERD market is projected to grow significantly from 2026 to 2036, driven by advancements in treatment and increased awareness. AstraZeneca's recent approval of ETCAMAH (camizestrant) is expected to accelerate the adoption of oral SERDs. However, challenges persist, including the need for SERDs to prove their efficacy against established therapies.

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AZN
Oct 2, 2026
AZNPhases

Daiichi Sankyo and AstraZeneca Enter into Clinical Trial Collaboration with Summit Therapeutics to Evaluate Datroway® in Combination with Ivonescimab Across Multiple Tumor Types

Daiichi Sankyo and AstraZeneca have formed a clinical trial collaboration with Summit Therapeutics to assess the efficacy of Datroway® in combination with ivonescimab across various tumor types, including lung and breast cancers. The collaboration will commence with a phase 3 trial focusing on first-line treatment for triple negative breast cancer. This partnership aims to enhance treatment options for patients with these cancers.

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AZN
Sep 28, 2026
AZNPhases

Eccogene Receives $50 Million Milestone Payment from AstraZeneca Following Initiation of Global Phase 3 Program for Elecoglipron (AZD5004/ECC5004)

Eccogene has received a $50 million milestone payment from AstraZeneca following the initiation of a Global Phase 3 program for Elecoglipron (AZD5004/ECC5004). This payment marks a significant step in the development of the drug, showcasing the partnership's progress. The Phase 3 program is crucial for the drug's potential approval and market entry.

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AZN
Sep 23, 2026
AZNGeneral

Polaris Rx Named Exclusive U.S. Distributor of AstraZeneca's FluMist® Home Service for Second Consecutive Year

Polaris Rx has been named the exclusive U.S. distributor for AstraZeneca's FluMist Home service for the 2026-2027 flu season, marking the second consecutive year of this partnership. This service allows individuals to conveniently order the flu vaccine online and have it delivered directly to their homes. The collaboration aims to improve access to flu vaccinations.

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AZN
Sep 14, 2026
AZNGeneral

Susan G. Komen® and AstraZeneca Partnership to Make Patient Navigation Available to All

Susan G. Komen has partnered with AstraZeneca to enhance patient navigation in breast cancer care. This initiative aims to integrate patient navigation into the national healthcare system, addressing barriers and improving access to timely treatments. The collaboration seeks to reduce patient stress and enhance adherence to cancer care plans across the nation.

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AZN
Sep 1, 2026
AZNFDA Updates

The Oral PCSK9 Inhibitor Market Enters High-Growth Phase Owing to the Approval of Merck's LIPFENDRA and the Emergence of Oral PCSK9 Inhibitor Drugs, Including, AstraZeneca's AZD0780, Aqur's AQR-008, and Others | DelveInsight

The PCSK9 inhibitors market is experiencing significant growth due to the approval of Merck's LIPFENDRA and the introduction of new oral therapies, including AstraZeneca's AZD0780. This expansion is driven by the increasing prevalence of hypercholesterolemia and cardiovascular diseases, leading to a higher demand for effective lipid-lowering treatments. The report highlights the potential for improved patient adherence and broader treatment options in this evolving market.

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AZN
Sep 1, 2026
AZNGeneral

AstraZeneca completes global license agreement for oral EGFR inhibitor ZEGFROVY® (sunvozertinib) for lung cancer

AstraZeneca has finalized a global license agreement with Dizal Pharmaceutical for ZEGFROVY (sunvozertinib), an oral EGFR inhibitor for lung cancer. This agreement grants AstraZeneca worldwide rights to develop and commercialize the drug, which is already approved in the US and China for second-line treatment in adults.

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AZN
Jul 27, 2026
AZNGeneral

AstraZeneca results: H1 and Q2 2026

AstraZeneca reported strong financial results for H1 2026, with total revenue increasing by 9% compared to the previous year. Product sales reached $28.9 billion, reflecting an 8% growth. The company's core EPS also showed a positive trend, rising by 12%. However, collaboration revenue experienced a decline of 6%. Overall, the results indicate a solid performance despite some challenges.

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AZN
Jul 14, 2026
AZNGeneral

Dizal Announces Global Exclusive License Agreement with AstraZeneca for Zegfrovy

Dizal has entered a global exclusive license agreement with AstraZeneca for Zegfrovy, an EGFR inhibitor for lung cancer. The deal includes a $600M upfront payment and potential milestone payments of up to $900M. Zegfrovy is already approved in China and the US for treating advanced NSCLC with specific mutations. AstraZeneca aims to leverage its oncology expertise to expand Zegfrovy's reach.

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AZN
Jul 7, 2026
AZNGeneral

Helix Announces Multi-Year Agreement with AstraZeneca to Support Genomic Research for Drug Discovery and Development

Helix has entered a multi-year agreement with AstraZeneca to provide access to its GenoSphere cohorts, which include extensive genomic and clinical data. This collaboration aims to enhance drug discovery and development by leveraging integrated clinico-genomic data. The partnership is expected to accelerate biomedical research and improve the development of targeted therapies.

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AZN
Jul 2, 2026
AZNPhases
▲ +6.1%on this newsshared move

Abbisko Therapeutics and AstraZeneca Enter a Strategic Collaboration to Conduct the Clinical Trial of Lumipodlin (ABSK043), a First-in-Class Oral PD-L1 Inhibitor, in Combination with TAGRISSO® for NSCLC

Abbisko Therapeutics has partnered with AstraZeneca to conduct a Phase I/II clinical trial for lumipodlin (ABSK043), an oral PD-L1 inhibitor, in combination with TAGRISSO® for treating non-small cell lung cancer (NSCLC). The trial aims to evaluate the safety and efficacy of this novel therapy for patients with EGFR mutations and high PD-L1 expression. The IND application for the study was recently approved by the National Medical Products Administration.

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AZN
Jun 24, 2026
AZNGeneral

AstraZeneca and YMCA of the USA Announce Landmark Partnership Aimed to Address Gaps in Cancer Care

AstraZeneca has formed a partnership with YMCA of the USA to tackle disparities in cancer care. This collaboration aims to enhance accessibility and improve health outcomes for communities. The initiative is expected to address critical gaps in healthcare services related to cancer treatment and support.

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AZN
Jun 9, 2026
AZNGeneral

Lung Cancer Research Foundation and AstraZeneca Announce Open Call for Research Proposals with Focus on Small Cell Lung Cancer

The Lung Cancer Research Foundation and AstraZeneca have announced two research awards aimed at improving treatment outcomes for small cell lung cancer (SCLC). The awards, totaling $750,000, will support innovative strategies and patient advocacy efforts. Submissions for research proposals are open until July 15, 2026, with the goal of advancing understanding and treatment of this challenging cancer.

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AZN
May 22, 2026
AZNFDA Updates

Datroway® Approved in the U.S. as First TROP2 Directed Antibody Drug Conjugate for First-Line Treatment of Patients with Metastatic Triple Negative Breast Cancer Who Are Not PD-1/PD-L1 Inhibitor Candidates

Datroway® has received U.S. approval as the first TROP2 directed antibody drug conjugate. It is intended for first-line treatment of patients with metastatic triple negative breast cancer who are not eligible for PD-1/PD-L1 inhibitors. This approval marks a significant advancement in treatment options for this patient population.

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AZN
May 20, 2026
AZNGeneral

स्तन तथा फेफड़ों के कैंसर में एडवांस पैथोलॉजी के लिए एक स्थायी इकोसिस्टम को गति देने में सहायता करने के लिए AstraZeneca ने Roche Diagnostics Asia Pacific

AstraZeneca has partnered with Roche Diagnostics Asia Pacific to enhance digital pathology capabilities for cancer diagnostics. This collaboration aims to leverage AI technology to improve patient outcomes and diagnostic accuracy. The initiative is expected to significantly benefit the healthcare landscape in Asia Pacific, particularly in the management of cancer treatments.

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AZN
May 18, 2026
AZNGeneral

AstraZeneca Collaborates with Roche Diagnostics Asia Pacific to Help Accelerate Sustainable Ecosystem for Advanced Pathology in Breast and Lung Cancer

AstraZeneca and Roche Diagnostics Asia Pacific have entered a three-year Memorandum of Understanding to enhance digital pathology capabilities across nine Asian markets. This collaboration aims to improve biomarker testing for breast and lung cancer through AI-powered solutions and educational initiatives. The partnership addresses significant gaps in diagnostic processes and aims to standardize and improve cancer care.

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AZN
May 15, 2026
AZNFDA Updates

FDA approves AstraZeneca’s new kind of hypertension drug

The FDA has approved AstraZeneca's Baxfendy, a novel hypertension treatment expected to generate over $5 billion annually. The drug, which targets a root cause of hypertension, shows promise in clinical trials and is anticipated to launch soon, although it poses competitive challenges for other biotech firms.

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AZN
May 1, 2026
AZNFDA Updates

TRUQAP® (capivasertib) recommended by FDA Advisory Committee for PTEN-deficient metastatic hormone-sensitive prostate cancer

The FDA's Oncologic Drugs Advisory Committee has recommended AstraZeneca's TRUQAP (capivasertib) in combination with abiraterone and ADT for PTEN-deficient metastatic hormone-sensitive prostate cancer. This recommendation is based on favorable results from the CAPItello-281 Phase III trial, which demonstrated a significant reduction in disease progression. The treatment addresses a critical need for patients with limited options and is the first targeted therapy for this cancer subtype.

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AZN
Mar 9, 2026
AZNFDA Updates

Koselugo approved in Canada for plexiform neurofibromas in adults with neurofibromatosis type 1

Koselugo (selumetinib) has been approved in Canada for adults with neurofibromatosis type 1 (NF1) suffering from symptomatic, inoperable plexiform neurofibromas. This approval follows positive results from the KOMET Phase III trial, which showed a 20% objective response rate in tumor size reduction. Experts highlight the significance of this treatment option for patients who previously had limited therapeutic choices.

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About AstraZeneca PLC

96,100 employees astrazeneca.com
HeadquartersCambridge
Founded1913
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