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RT-114

Phase 1

Obesity | Small molecule | Metabolic |Rani Therapeutics Holdings, Inc.|Trials Updated: Mar 23, 2025

RT-114 target and mechanism

Molecular targetGLP-1/GLP-2
Target classReceptor
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment60

FDA Designations

No designations recorded

RT-114 clinical trials

RT-114 · 1 trial · 1 indication

Phase 1 1
NCT06891287An Early Phase Study of RT-114Obesity
NOT YET_RECRUITING60 Analytics
PHASE1NOT YET_RECRUITING
An Early Phase Study of RT-114
ObesityUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
RT-114 is the RaniPill capsule with PG-102 for the treatment of obesityCOMBINATION_PRODUCTRT-114 is the RaniPill capsule with PG-102 for the treatment of obesity.
PG-102DRUGPG-102 is a drug for the treatment of obesity.
PlaceboOTHERThe placebo is the RaniPill with saline instead of a drug.
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Frequently asked questions about RT-114

What is RT-114?

RT-114 is an investigational oral capsule being developed for the treatment of obesity. It combines the RaniPill capsule with PG-102, a GLP-1/GLP-2 receptor agonist. Rani Therapeutics Holdings, Inc. is developing RT-114, which is currently in Phase 1 clinical development.

What is RT-114 used for in obesity?

RT-114 is being developed for the treatment of obesity. It is designed to deliver PG-102, a GLP-1/GLP-2 receptor agonist, orally using the RaniPill capsule. The program is in Phase 1 testing and has not been approved for any indication.

What does RT-114 target?

RT-114 targets the GLP-1 and GLP-2 receptors. PG-102, the active agent delivered by the RaniPill capsule, acts as a GLP-1/GLP-2 receptor agonist. This dual receptor activity is the basis for its development in obesity.

Who is developing RT-114?

RT-114 is being developed by Rani Therapeutics Holdings, Inc., which trades under the ticker RANI. The company is advancing RT-114, an oral RaniPill capsule formulation of PG-102, for obesity.

What phase is RT-114 in?

RT-114 is in Phase 1 clinical development. It is investigational and has not been approved by the FDA or any other regulatory agency. One Phase 1 trial is registered, and it is not yet recruiting participants.

What clinical trials is RT-114 in?

RT-114 is being studied in one Phase 1 trial, NCT06891287, titled An Early Phase Study of RT-114. The trial targets enrollment of 60 participants with obesity, is uncontrolled, and its status is not yet recruiting.