Recent Updates
Recently added Catalysts

Petrelintide

Phase 2

Obesity or Overweight | Small molecule | Metabolic |Roche Holding AG|Last Updated: Aug 7, 2026

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment486

FDA Designations

No designations recorded

Clinical trial landscape

Petrelintide · 1 trial · 1 indication

Phase 2 1
NCT07589686A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or OverweightObesity or Overweight
NOT YET_RECRUITING486 Analytics
PHASE2NOT YET_RECRUITING
A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight
Obesity or OverweightUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage Change in Body Weight between Arms 1 and 6
From Baseline to Week 40

Secondary Endpoints

Percentage Change in Body Weight between Arms 2, 3 and Arm 6
From Baseline to Week 40
Percentage Change in Body Weight between Arms 1, 2, 3 and Arms 4, 5
From Baseline to Week 40
Percentage of Participants Achieving Body Weight Loss
From Baseline to Week 40
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Arm 1: Petrelintide + Enicepatide Dosing Regimen 1EXPERIMENTAL -
Arm 2: Petrelintide + Enicepatide Dosing Regimen 2EXPERIMENTAL -
Arm 3: Petrelintide + Enicepatide Dosing Regimen 3EXPERIMENTAL -
Arm 4: Petrelintide-matching Placebo + EnicepatideEXPERIMENTAL -
Arm 5: Petrelintide + Enicepatide-matching PlaceboEXPERIMENTAL -
Arm 6: Petrelintide-matching Placebo + Enicepatide-matching PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
PetrelintideDRUGPetrelintide will be administered subcutaneously to participants once weekly
EnicepatideCOMBINATION_PRODUCTEnicepatide will be administered subcutaneously to participants once weekly
Petrelintide-matching PlaceboDRUGMatching placebo to Petrelintide will be administered subcutaneously to participants once weekly
Enicepatide-matching PlaceboCOMBINATION_PRODUCTMatching placebo to Enicepatide will be administered subcutaneously to participants once weekly
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Key Inclusion Criteria: * Male or female participants with Body Mass Index (BMI) ≥ 30 kg/m² OR BMI ≥ 27 kg/m² to \< 30 kg/m² with at least one weight-related comorbidity * History of at least one self-reported unsuccessful dietary effort to lose body weight Key Exclusion Criteria: * HbA1c ≥ 48 mm...

Unlock Eligibility Criteria

Recent Changes (Last 90 Days)

LOWAug 7, 2026NCT07589686lastUpdatePostDate: changed
LOWAug 7, 2026NCT07589686lastUpdatePostDate: changed

Frequently asked questions about Petrelintide

What is Petrelintide used for in obesity or overweight?

Petrelintide is an investigational small molecule being developed for the treatment of obesity or overweight. It is currently in Phase 2 clinical development and has not been approved by regulatory authorities. The drug is being studied in adults aged 18 years and older with these conditions.

Who makes Petrelintide?

Petrelintide is being developed by Roche Holding AG, which trades under the ticker RHHBY. The company is conducting a Phase 2 clinical trial to evaluate the drug's safety and efficacy in adults with obesity or overweight.

What phase is Petrelintide in?

Petrelintide is currently in Phase 2 clinical development. It is an investigational drug and has not been approved by the FDA or other regulatory agencies. The ongoing Phase 2 trial is designed to assess the drug's dosing and effects in adults with obesity or overweight.

What clinical trials is Petrelintide in?

Petrelintide is being studied in a Phase 2 clinical trial registered as NCT07589686. This randomized, double-blind, placebo-controlled study is titled 'A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight' and aims to enroll 486 participants.

How does Petrelintide work?

Petrelintide is a peptide-based small molecule, classified under the '-tide' target class. It is being investigated for its potential to address obesity or overweight, though the specific molecular target has not been disclosed in available information.

Is Petrelintide FDA approved?

No, Petrelintide is not FDA approved. It is an investigational drug currently in Phase 2 clinical trials. The ongoing study, NCT07589686, is a randomized, double-blind, placebo-controlled trial that has not yet begun recruiting participants.