Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT07575945 | A Study to Learn if a Medicine Called Itraconazole Changes How the Body Processes the Study Medicine PF-08642534 in Healthy Adults. | PHASE1 | NOT YET_RECRUITING | 14 | — | — | May 5, 2026 | Jul 23, 2026 | May 8, 2026 | 1 | United States |
| Arm | Type | Description |
|---|---|---|
| Period 1--PF-08642534 | EXPERIMENTAL | Participants will receive a single dose of PF-08642534 |
| Period 2--itraconazole plus PF-08642534 | EXPERIMENTAL | Participants will receive single doses of PF-08642534) in presence of itraconazole. |
| Name | Type | Description |
|---|---|---|
| PF-08642534 | DRUG | Participants will receive a single dose of PF-08642534 |
| Itraconazole | DRUG | Participants will receive itraconazole once daily for 13 days (Day 12 to Day 24) |
Inclusion criteria: * Generally healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, blood pressure, pulse rate and standard 12-lead electrocardiogram (ECG). * Body Mass Index (BMI) of 16-30 kilograms per meter squared, inclusive, and a tota...