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REGN20934

Phase 1

Overweight or Obesity | Small molecule | Metabolic |Regeneron Pharmaceuticals, Inc.|Last Updated: May 18, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment90
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07594093Safety and Drug Concentrations of REGN20934 in Adults With Overweight or ObesityPHASE1 NOT YET_RECRUITING 90Jun 15, 2026Feb 22, 2027May 18, 2026 -
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Study Endpoints
Primary Endpoints
Occurrence of Treatment Emergent Adverse Events (TEAEs)
Up to 16 weeks
Severity of TEAEs
Up to 16 weeks
Secondary Endpoints
REGN20934 concentration in serum
Up to 16 weeks
Occurrence of Anti-Drug Antibodies (ADAs) to REGN20934
Up to 16 weeks
Magnitude of ADAs to REGN20934
Up to 16 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
REGN20934EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
REGN20934DRUGAdministered per the protocol
PlaceboDRUGAdministered per the protocol
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersYes

Key Inclusion Criteria: 1\. Has a Body Mass Index (BMI) 25 to 35 kg/m\^2 Key Exclusion Criteria: 1. A self-reported change of body weight \>5 kg within approximately 90 days of visit 2 2. History of type 1 or type 2 diabetes 3. History of clinically significant cardiovascular, respiratory, hepati...

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Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT07594093studyFirstPostDate: changed
LOWMay 21, 2026NCT07594093NEW_TRIAL: changed
LOWMay 21, 2026NCT07594093NEW_TRIAL: changed