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yttrium Y 90-edotreotide

Phase 2

Breast Cancer | Unknown | Oncology |Novartis AG|Last Updated: May 1, 2013

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment275

FDA Designations

No designations recorded

Clinical trial landscape

yttrium Y 90-edotreotide · 2 trials · 8 indications

Phase 2 1Phase 1 1
NCT00006370Radiolabeled SMT-487 (Yttrium Y 90-DOTA-tyr3-octreotide) in Treating Patients With Refractory Small Cell Lung Cancer or Metastatic Breast CancerBreast Cancer
COMPLETED275 Analytics
PHASE2COMPLETED
Radiolabeled SMT-487 (Yttrium Y 90-DOTA-tyr3-octreotide) in Treating Patients With Refractory Small Cell Lung Cancer or Metastatic Breast Cancer
Breast CancerUnlock trial analytics

Study Design & Arms

PurposeTREATMENT

Interventions

NameTypeDescription
yttrium Y 90-edotreotideRADIATION -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

DISEASE CHARACTERISTICS: Histologically confirmed small cell lung cancer Must have received one prior chemotherapy regimen and relapsed OR Diagnosis of metastatic breast cancer No more than two prior chemotherapy regimens for metastatic disease Measurable disease Prior radiotherapy to measurable les...

Countries:United States
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Competitive Landscape -Breast Cancer 402 trials

Top 20 of 92 competitors

CompanyTickerTrialsLead PhaseDrugs
AstraZeneca PLCAZN47PHASE3Fulvestrant, Capivasertib
Merck & Co., Inc.MRK12PHASE3Pembrolizumab, Paclitaxel, Doxorubicin, Epirubicin, Cyclophosphamide
Eli Lilly and CompanyLLY27PHASE3Abemaciclib, Standard Adjuvant Endocrine Therapy
BioNTech SE Sponsored ADRBNTX7PHASE3DB-1303/BNT323, T-DM1
Gilead Sciences, Inc.GILD13PHASE3Sacituzumab Govitecan-hziy, Eribulin, Capecitabine Product, Gemcitabine, Vinorelbine
Novartis AG Sponsored ADRNVS30PHASE3Ribociclib
Pfizer Inc.PFE34PHASE3ARV-471, Fulvestrant
BeOne Medicines Ltd. Sponsored ADRONC5PHASE3BGB-43395, Letrozole, Abemaciclib, Palbociclib, Ribociclib
Olema Pharmaceuticals, Inc.OLMA5PHASE3Palazestrant, Fulvestrant, Anastrozole, Letrozole, Exemestane
Jazz Pharmaceuticals Public Limited CompanyJAZZ3PHASE3Zanidatamab, Trastuzumab, Eribulin, Vinorelbine, Gemcitabine
Celcuity Inc.CELC3PHASE3Gedatolisib, Palbociclib, Fulvestrant, Alpelisib
Relay Therapeutics, Inc.RLAY2PHASE3Zovegalisib, Capivasertib, Fulvestrant
GSK plc Sponsored ADRGSK2PHASE3Niraparib
Greenwich LifeSciences, Inc.GLSI1PHASE3GLSI-100
Bristol-Myers Squibb CompanyBMY5PHASE2Iza-bren, Nab-paclitaxel, Paclitaxel, Capecitabine, Carboplatin
BriaCell Therapeutics CorpBCTX2PHASE3SV-BR-1-GM, Cyclophosphamide, Interferon infiltration of the inoculation site, Retifanlimab, Treatment of Physician's Choice
Incyte CorporationINCY4PHASE2Ruxolitinib, Capecitabine, Regorafenib
Natera, Inc.NTRA3PHASE2Discontinuation of the anti-HER2 maintenance therapy
Puma Biotechnology, Inc.PBYI3PHASE2Neratinib, Loperamide, Colesevelam
Atossa Therapeutics, Inc.ATOS1PHASE2endoxifen, goserelin
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Frequently asked questions about yttrium Y 90-edotreotide

What is yttrium Y 90-edotreotide used for?

Yttrium Y 90-edotreotide is an investigational radiopharmaceutical being studied for treating brain and central nervous system tumors and breast cancer. It has been evaluated in clinical trials for patients with refractory or recurrent cancers, including these indications.

Who makes yttrium Y 90-edotreotide?

Yttrium Y 90-edotreotide is being developed by Novartis AG, which trades under the ticker NVS. The company has sponsored clinical trials investigating this drug in oncology settings.

What phase is yttrium Y 90-edotreotide in?

Yttrium Y 90-edotreotide is in Phase 1 clinical development. It remains investigational and has not been approved by regulatory authorities. One Phase 1 trial has been completed, along with a separate Phase 2 trial.

What clinical trials is yttrium Y 90-edotreotide in?

Yttrium Y 90-edotreotide has been studied in two completed trials: NCT00006368, a Phase 1 study in patients with refractory or recurrent cancer, and NCT00006370, a Phase 2 study in patients with refractory small cell lung cancer or metastatic breast cancer.

How does yttrium Y 90-edotreotide work?

Yttrium Y 90-edotreotide is a radiopharmaceutical that delivers radioactive yttrium-90 to cancer cells. It is designed to target somatostatin receptors, which are often overexpressed on certain tumor types, allowing for targeted radiation therapy.