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LY4329090

Phase 1

Obesity | Small molecule | Metabolic |Eli Lilly and Company|Trials Updated: Oct 8, 2026

LY4329090 development status

Highest phase Phase 1
Registered trials 1 across 1 sponsor since Sep 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment184

FDA Designations

No designations recorded

LY4329090 clinical trials

LY4329090 · 1 trial · 2 indications

Phase 1 1
NCT07808073A Study of LY4329090 in Participants With Obesity or Overweight Who Are Otherwise HealthyObesity
RECRUITING184 Analytics
PHASE1RECRUITING
A Study of LY4329090 in Participants With Obesity or Overweight Who Are Otherwise Healthy
ObesityUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
End of Study (Week 28)

Secondary Endpoints

Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY4329090
Baseline through Week 28
PK: Time of Maximum Observed Drug Concentration (Tmax) of LY4329090
Baseline through Week 28
PK: Area Under the Concentration Versus Time Curve (AUC) of LY4329090
Baseline through Week 28
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
LY4329090 Part AEXPERIMENTALParticipants will receive LY4329090 administered subcutaneously (SC)
Placebo Part AEXPERIMENTALParticipants will receive placebo administered SC
LY4329090 Part BEXPERIMENTALParticipants will receive LY4329090 administered SC
Placebo Part BPLACEBO_COMPARATORParticipants will receive placebo administered SC

Interventions

NameTypeDescription
LY4329090DRUGAdministered SC
PlaceboDRUGAdministered SC
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites3

Inclusion Criteria: * Participant must be 18 (21 for Singapore site) to 65 years of age, inclusive, at the time of signing the informed consent. * Are overtly healthy with no comorbidities related to body mass index (BMI). * Have a BMI between 27.0 kilograms per square meter (kg/m²) and 40.0 kg/m²,...

Countries:United StatesSingapore
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Recent Changes (Last 90 Days)

LOWOct 8, 2026NCT07808073Status: NOT_YET_RECRUITING → RECRUITING
LOWOct 8, 2026NCT07808073Status: NOT_YET_RECRUITING → RECRUITING
LOWSep 22, 2026NCT07808073lastUpdatePostDate: changed
LOWSep 22, 2026NCT07808073lastUpdatePostDate: changed
LOWSep 8, 2026NCT07808073NEW_TRIAL: changed
LOWSep 8, 2026NCT07808073NEW_TRIAL: changed

Frequently asked questions about LY4329090

What is LY4329090 used for?

LY4329090 is an investigational small molecule being studied for the treatment of obesity and overweight in adults who are otherwise healthy. It is in Phase 1 clinical development and has not been approved for any use. Eli Lilly and Company is developing the drug.

Who makes LY4329090?

LY4329090 is being developed by Eli Lilly and Company, which trades on the New York Stock Exchange under the ticker LLY. Lilly is the sponsor of the Phase 1 clinical program evaluating the drug in obesity and overweight.

What phase is LY4329090 in?

LY4329090 is in Phase 1 clinical development. The program currently includes one recruiting Phase 1 trial in participants with obesity or overweight. The drug is investigational and has not been approved by the FDA or any other regulatory agency.

What clinical trials is LY4329090 in?

LY4329090 is being evaluated in one Phase 1 trial, NCT07808073, titled A Study of LY4329090 in Participants With Obesity or Overweight Who Are Otherwise Healthy. The trial is recruiting, plans to enroll 184 participants, and is being conducted in the United States and Singapore.

How is the LY4329090 Phase 1 trial designed?

The Phase 1 trial NCT07808073 is a randomized, double-blind, placebo-controlled study of LY4329090 in adults aged 18 years and older with obesity or overweight who are otherwise healthy. It plans to enroll 184 participants across sites in the United States and Singapore.