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trastuzumab derxutecan

Phase 2

Breast Cancer Metastatic | Antibody-Drug Conjugates (ADCs) | Oncology |AstraZeneca PLC|Trials Updated: Oct 29, 2026

trastuzumab derxutecan development status

Highest phase Phase 2
Registered trials 1 across 1 sponsor since Nov 2024

trastuzumab derxutecan target and mechanism

Molecular targetERBB2
Target classInhibitor
ModalityAntibody-Drug Conjugates (ADCs)

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment80

FDA Designations

No designations recorded

trastuzumab derxutecan clinical trials

trastuzumab derxutecan · 1 trial · 2 indications

Phase 2 1
NCT06680596Detecting Tumor DNA in the Blood of HR+/HER2-low Metastatic Breast Cancer Patients to Find Candidates for T-DXd TherapyBreast Cancer Metastatic
RECRUITING80 Analytics
PHASE2RECRUITING
Detecting Tumor DNA in the Blood of HR+/HER2-low Metastatic Breast Cancer Patients to Find Candidates for T-DXd Therapy
Breast Cancer MetastaticUnlock trial analytics

Study Endpoints

Primary Endpoints

Progression Free Survival (PFS)
From first treatment administration to disease progression or death, up to 5 years

The progression-free survival is the length of time during and after treatment of the disease with T-DXd that a patient lives with the disease but it does not get worse.

Secondary Endpoints

Overall survival (OS)
From the first T-DXd administration to death due to any cause, up to 5 years
Objective response Rate (ORR)
From first T-DXd Administration to 6 months after the first administration of treatment, up to 5 years
Duration of response (DoR)
From the date of first documentation to disease progression or death, up to 5 years
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
T-DXdEXPERIMENTALT-DXd will be administrated as an intra-venous injection of 5.4 mg/kg every three weeks (1 cycle = 21-day treatment).

Interventions

NameTypeDescription
trastuzumab derxutecanDRUGT-DXd will be administrated as an intra-venous injection of 5.4 mg/kg every three weeks (1 cycle = 21-day treatment).
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites40

SCREENING PHASE\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ Inclusion criteria 1. Patient must have signed the written informed consent for screening phase prior to any trial specific procedures. Note: When the patient is ph...

Countries:France
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Competitive Landscape -Breast Cancer 601 trials (matched to "Breast Cancer Metastatic")

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