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mRNA-2808

Phase 1

Relapsed or Refractory Multiple Myeloma | Small molecule | Oncology |Moderna, Inc.|Last Updated: Jul 24, 2026

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment166

FDA Designations

No designations recorded

Clinical trial landscape

mRNA-2808 · 1 trial · 1 indication

Phase 1 1
NCT07116616A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple MyelomaRelapsed or Refractory Multiple Myeloma
RECRUITING166 Analytics
PHASE1RECRUITING
A Study of mRNA-2808 in Participants With Relapsed or Refractory Multiple Myeloma
Relapsed or Refractory Multiple MyelomaUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with Dose-limiting Toxicity
Up to 28 days
Number of Participants with Treatment-emergent Adverse Events (TEAEs)
Up to 15 months

Secondary Endpoints

Maximum Plasma Concentration (Cmax)
Up to 1 year
Area Under the Concentration-time Curve (AUC)
Up to 1 year
Maximum Effect/Concentration of the Expressed Protein (Emax)
Up to 1 year
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
mRNA-2808EXPERIMENTALParticipants will receive mRNA-2808.

Interventions

NameTypeDescription
mRNA-2808DRUGintravenous
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites10

Key Inclusion Criteria: * RRMM with prior exposure to a proteasome inhibitor, an immunomodulatory drug (IMiD), and an anti-cluster of differentiation (CD38) monoclonal antibody. * Measurable disease defined as at least 1 of the following: * Serum M-protein ≥0.5 grams/deciliter * Urine M-protei...

Countries:United States
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Competitive Landscape -Multiple Myeloma 221 trials (matched to "Relapsed or Refractory Multiple Myeloma")

Top 20 of 25 competitors

CompanyTickerTrialsLead PhaseDrugs
AbbVie, Inc.ABBV16PHASE3Pomalidomide, Dexamethasone, Venetoclax
Bristol-Myers Squibb CompanyBMY18PHASE3Iberdomide, Lenalidomide
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK5PHASE3IGI, 10%
GSK plc Sponsored ADRGSK17PHASE3Belantamab mafodotin, Pomalidomide, Dexamethasone, Bortezomib
Johnson & JohnsonJNJ28PHASE3Talquetamab, Pomalidomide, Teclistamab, Elotuzumab, Dexamethasone
Regeneron Pharmaceuticals, Inc.REGN11PHASE3Linvoseltamab, Carfilzomib, Daratumumab, Dexamethasone, Pomalidomide
Pfizer Inc.PFE11PHASE3Elranatamab, Lenalidomide
Sanofi SA Sponsored ADRSNY17PHASE3Isatuximab, Dexamethasone, Pomalidomide, Montelukast, Paracetamol/ Acetaminophen
AstraZeneca PLCAZN5PHASE3AZD0120, Daratumumab, Carfilzomib, Dexamethasone, Bortezomib
Gilead Sciences, Inc.GILD3PHASE3Anitocabtagene Autoleucel, Cyclophosphamide, Fludarabine, Pomalidomide, Bortezomib
Karyopharm Therapeutics, Inc.KPTI6PHASE3Selinexor, Elotuzumab, Pomalidomide, Dexamethasone
Grifols, S.A. Sponsored ADR Class BGRFS1PHASE3Xembify
BioLineRX Ltd. Sponsored ADRBLRX1PHASE3BL-8040/kg, G-CSF
C4 Therapeutics, Inc.CCCC3PHASE2Cemsidomide, Dexamethasone
Cellectar Biosciences, Inc.CLRB1PHASE2Iopofosine I 131 single dose, Iopofosine I 131 fractionated dose
GeoVax Labs, Inc.GOVX1PHASE2COVID-19 Vaccine, Synthetic MVA-based SARS-CoV-2 Vaccine GEO-CM04S1
Autolus Therapeutics Plc Sponsored ADRAUTL1PHASE2AUTO CAR T cell therapy
Incyte CorporationINCY2PHASE1Ruxolitinib, Lenalidomide, Methylprednisolone
Moderna, Inc.MRNA2PHASE1mRNA-2808
BeOne Medicines Ltd. Sponsored ADRONC1PHASE1Sonrotoclax, Dexamethasone, Carfilzomib, Daratumumab, Pomalidomide
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Recent Changes (Last 90 Days)

LOWJul 24, 2026NCT07116616lastUpdatePostDate: changed
LOWJul 24, 2026NCT07116616lastUpdatePostDate: changed
LOWJun 29, 2026NCT07116616lastUpdatePostDate: changed
LOWJun 29, 2026NCT07116616lastUpdatePostDate: changed

Frequently asked questions about mRNA-2808

What is mRNA-2808 used for?

mRNA-2808 is an investigational therapy being developed for the treatment of relapsed or refractory multiple myeloma. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who makes mRNA-2808?

mRNA-2808 is being developed by Moderna, Inc., a biotechnology company traded on the NASDAQ under the ticker symbol MRNA. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational therapy.

What phase is mRNA-2808 in?

mRNA-2808 is currently in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory agencies and is still being studied in clinical trials to assess its safety and effectiveness.

What clinical trials is mRNA-2808 in?

mRNA-2808 is being studied in a Phase 1 clinical trial with the identifier NCT07116616. This trial is recruiting participants with relapsed or refractory multiple myeloma in the United States and aims to enroll approximately 166 participants aged 18 years and older.

Is mRNA-2808 a small molecule?

Yes, mRNA-2808 is classified as a small molecule therapeutic. It is being investigated for its potential role in treating relapsed or refractory multiple myeloma, a type of blood cancer.