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Stereotactic body radiotherapy

Phase 3

Colorectal Cancer. | Unknown | Other |Roche Holding AG|Last Updated: Oct 13, 2016

Development status

Highest phase Phase 3 run by Sun Yat-sen University (NCT04944914)
Phase scored for RHHBYPhase 2
Registered trials 10 across 9 sponsors since Apr 2012

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment11

FDA Designations

No designations recorded

Clinical trial landscape

Stereotactic body radiotherapy · 1 trial · 1 indication

Phase 2 1
NCT01569984Radiosensitization of AVASTIN® (Bevacizumab) With Stereotactic Body Radiotherapy for Colorectal Liver MetastasisColorectal Cancer.
COMPLETED11 Analytics
PHASE2COMPLETED
Radiosensitization of AVASTIN® (Bevacizumab) With Stereotactic Body Radiotherapy for Colorectal Liver Metastasis
Colorectal Cancer.
NCT0156998411
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Study Endpoints

Primary Endpoints

Tumor perfusion
day 24

Tumor perfusion as measured by DCE-CT

Secondary Endpoints

Blood flow
Day 24
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Avastin, SBRTEXPERIMENTAL2 treatments of avastin followed by 6 treatments of SBRT every other day.

Interventions

NameTypeDescription
Stereotactic body radiotherapyRADIATIONAvastin 7.5 mg/kg IV x 2 doses 14 days apart
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Histological and/or cytological diagnosis of colorectal cancer with liver metastases confirmed on imaging scans 2. 1-3 liver metastatic lesions confirmed on imaging scans 3. Maximum size of target metastatic lesion is 6 cm or less 4. At least 700 cc of liver uninvolved by tum...

Countries:Canada
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Competitive Landscape -Colorectal Cancer 257 trials (matched to "Colorectal Cancer.")

Top 20 of 71 competitors

CompanyTickerTrialsLead PhaseDrugs
AbbVie, Inc.ABBV8PHASE3Telisotuzumab Adizutecan, ABBV-400, Azirkitug, Budigalimab
Bristol-Myers Squibb CompanyBMY7PHASE3Ipilimumab, Nivolumab, Adagrasib, Pumitamig, BMS-986340
Merck & Co., Inc.MRK6PHASE3Pembrolizumab, Calderasib, MK-4830, Sacituzumab tirumotecan
Johnson & JohnsonJNJ5PHASE3Amivantamab, JNJ-89402638, JNJ-95437446
Pfizer Inc.PFE10PHASE3PF-08634404, Bevacizumab, Tucatinib, Trastuzumab, tisotumab vedotin
GSK plc Sponsored ADRGSK6PHASE3Dostarlimab, GSK4418959, GSK5460025
Summit Therapeutics IncSMMT3PHASE3Ivonescimab
Exelixis, Inc.EXEL5PHASE3Zanzalintinib, Cabozantinib
Agenus Inc.AGEN4PHASE3Balstilimab, Botensilimab, AGEN2034
Incyte CorporationINCY2PHASE3INCA33890, Ruxolitinib
Amgen Inc.AMGN1PHASE3Sotorasib, Panitumumab, Bevacizumab-awwb
Eli Lilly and CompanyLLY8PHASE2LY2157299, LY4066434, Cetuximab, Gemcitabine, Pemetrexed
AstraZeneca PLCAZN8PHASE2Datopotamab deruxtecan, Volrustomig, Rilvegostomig, FPI-2053, FPI-2107
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK5PHASE2fruquintinib
BioNTech SE Sponsored ADRBNTX3PHASE2Autogene cevumeran, Pumitamig, BNT314
Novartis AG Sponsored ADRNVS7PHASE2Dabrafenib, trametinib, Opnurasib, TNO155, DKY709
Regeneron Pharmaceuticals, Inc.REGN2PHASE2Cemiplimab
Revolution Medicines, Inc.RVMD7PHASE1Elironrasib, Daraxonrasib, Zoldonrasib, RMC-5127
Jazz Pharmaceuticals Public Limited CompanyJAZZ2PHASE2Zanidatamab
Cardiff Oncology, Inc.CRDF1PHASE2Onvansertib
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