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Summit Therapeutics Inc.

SMMTFDA catalysts, PDUFA dates & pipeline intelligence
$14.56
▼ -0.91 · -5.85%

Financials

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Operating CF
Total Assets
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Quarterly Cash
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52W LOW $12.0752W HIGH $29.23
Volume
3.69 M
Value Traded
51.16 M
Short % Float
27.03%
Days to Cover
4.8
-6.94%Week
-6.4%1 Month
+10.57%3 Month
-34.49%6 Month
+117.25%5 Year
+65.87%All Time

Cash Data

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  • SEC Filing

Key Stats

Market Cap
11.57 B
EPS (TTM)
-1.07
P/E Ratio
-
Ent. Value
10.95 B
Total Shares
797.75 M
Float Shares
152.24 M
Insiders
80.92%
Institutions
17.18%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
Phase 2 data presentation
Ivonescimab (AK112)
Recurrent/metastatic thymic carcinoma, first-line
Phase 2BiologicsOncology
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

SMMT Catalyst Timeline

Dated clinical, regulatory and corporate events for Summit Therapeutics Inc.

Catalyst Timeline

Dated clinical, regulatory & corporate events for Summit Therapeutics Inc.

805Total events
9Upcoming
175Tier-1 (high impact)
2011 to 2027Coverage

Upcoming catalysts 2

T1PDUFA Date
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IvonescimabApproved
T2Timing Guidance
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IvonescimabApproved

Event history 50

▲Oral PresentationIvonescimabApprovedPresentation
HARMONi-GI1 data featured in Presidential Symposium II at ESMO 2026 Congress, Madrid
advanced biliary tract cancersource ↗
▲Late-BreakerIvonescimabApprovedPresentation
HARMONi-GI1 ivonescimab plus chemo vs durvalumab plus chemo selected as ESMO 2026 Late-Breaking Abstract
first-line advanced biliary tract cancersource ↗
●Oral PresentationIvonescimabApprovedPresentation
Phase Ib/II AK112 first-line IMDC favorable-risk aRCC oral presentation at ESMO 2026 (Abstract #3592O)
advanced renal cell carcinomasource ↗
▲Primary Endpoint MetIvonescimabApprovedClinical Data
Ivonescimab regimen achieved statistically significant and clinically meaningful OS superiority over durvalumab regimen
advanced biliary tract cancersource ↗
▲Topline ReadoutIvonescimabApprovedClinical Data
HARMONi-GI1 Phase III topline: ivonescimab + chemo met OS primary endpoint vs durvalumab + chemo
advanced biliary tract cancersource ↗
●Safety Data UpdateIvonescimabApprovedClinical Data
Manageable safety profile consistent with prior Phase III studies; no additional safety signals
advanced biliary tract cancersource ↗
▲Secondary Endpoint DataIvonescimabApprovedClinical Data
Key secondary endpoints met: PFS HR 0.61, ORR 53.8% vs 32.5%, DCR 91.5% vs 77.8%
advanced biliary tract cancersource ↗
●Poster PresentationIvonescimabApprovedPresentation
Phase II neoadjuvant ivonescimab plus gemcitabine/nab-paclitaxel in pancreatic cancer poster at ESMO 2026 (Abstract #3161P)
borderline resectable pancreatic cancersource ↗
●Poster PresentationIvonescimabApprovedPresentation
Phase II AK112 plus radiotherapy and nab-paclitaxel in 2L gastric/GEJ adenocarcinoma poster at ESMO 2026 (Abstract #2898P)
gastric or gastroesophageal junction adenocarcinomasource ↗
▲Partnership / LicenseIvonescimabApprovedCorporate
Summit and Lunit announce research agreement to apply Lunit SCOPE IO AI pathology platform to ivonescimab immuno-oncology development
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Past FDA Catalysts and PDUFA Decisions

How SMMT actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-10-25Ivonescimab (AK112) Phase 1b/2 data presentation Phase 1b/2
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

Pipeline Score
Pipeline Value
Valuation Signal
1
Drugs Scored
rNPV / MCap
Top Drug
Top 9%
Mid Cap
(rank 60 of 657)
Percentile Rank
Showing 5 of 16 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
Ivonescimab Monoclonal antibodyNCT05899608Non Small Cell Lung CancerPhase 3 ACTIVE NOT_RECRUITING 2,538Dec 31, 2029
Ivonescimab Monoclonal antibodyNCT05382442Metastatic Colorectal CancerPhase 3 ACTIVE NOT_RECRUITING 984Aug 12, 2028
Ivonescimab Monoclonal antibodyNCT07815665Metastatic Urothelial CarcinomaPhase 2 RECRUITING 800Dec 31, 2030
Ivonescimab combined with Cadonilimab Monoclonal antibodyNCT07877194Renal Cell Carcinoma, Clear CellPhase 2 NOT YET_RECRUITING 100Dec 12, 2029
Ivonescimab Monoclonal antibodyNCT06396065Non-Squamous Non-small Cell Lung CancerNDA/BLA ACTIVE NOT_RECRUITING 420Dec 31, 2026
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PTRS, rNPV, enrollment velocity, trial design quality and ML risk signals for every asset above.
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Clinical Trial Results

Readouts, endpoints and source filings for every SMMT program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
ivonescimab advanced biliary tract cancerPhase 32026-10-25overall survival superiorityRead MoreIvonescimab Plus Chemotherapy Demonstrates Overall Survival Superiority Compared to Durvalumab Plus Chemotherapy in First-Line Treatment of Patients with Advanced Biliary Tract Cancer in HARMONi-GI1 Study Conducted by Akeso in ChinaRead More
Scroll for more · summaries link to the source press release
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Inside Trades

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Monthly insider buys and sells against the stock price, with the insider sentiment reading.
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InsiderSideSharesPriceValueDate
DUGGAN ROBERT WDirector, Officer (Co-Chief Executive Officer), 10% OwnerBuy 3,810,000 573,883,879 held$13.12 06/12/2026
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
BAKER BROS. ADVISORS 2.4 % (-40 %) 477.70 M 32.79 M -9.91% ( -3.60 M)
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Shares held by hedge funds each quarter, and who bought or sold.

SMMT Institutional Ownership Trends

SMMT Short Interest

Shares sold short, counted twice a month.

27.03%
Short % of Float
of tradable shares sold short
41.2M
Shares Sold Short
+0.2% vs prior count
4.8 Moderate
Days to Cover
trading days of normal volume to buy every short share back
8.5M
Avg Daily Volume
the average used for days to cover
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Two years of days to cover and shares sold short, with every count and its change.
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Options Data

Option Volume

Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg

Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2026-10-30
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Per-expiry call and put volume, open interest, put-call ratios and implied volatility.
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Real-Time Option Chain

CallsStrikePuts
LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

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Competitive positioning

How SMMT ranks across every disease it competes in

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See how SMMT ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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SMMT News

SMMT
Oct 25, 2026
SMMTPhases
▼ -5.9%today

Ivonescimab Plus Chemotherapy Demonstrates Overall Survival Superiority Compared to Durvalumab Plus Chemotherapy in First-Line Treatment of Patients with Advanced Biliary Tract Cancer in HARMONi-GI1 Study Conducted by Akeso in China

Summit Therapeutics' partner Akeso announced that ivonescimab plus chemotherapy demonstrated a statistically significant overall survival benefit compared to durvalumab plus chemotherapy in the Phase III HARMONi-GI1 study for advanced biliary tract cancer. The study showed a 25% reduction in the risk of death, with a median overall survival of 14.9 months for ivonescimab versus 12.1 months for durvalumab.

Read more →
SMMT
Oct 23, 2026
SMMTGeneral
▼ -5.9%today

Summit Therapeutics and Lunit Announce Agreement to Apply AI-powered SCOPE IO Platform for Tumor Microenvironment Analysis in Immuno-Oncology Development

Summit Therapeutics and Lunit have entered a research agreement to utilize Lunit's AI-powered SCOPE IO platform for tumor microenvironment analysis. This partnership aims to support Summit's immuno-oncology programs, particularly with the investigational drug ivonescimab. The collaboration seeks to leverage AI to enhance biomarker discovery and patient selection in cancer therapies.

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SMMT
Oct 22, 2026
SMMTConferences/Events

Ivonescimab Data Sets across Multiple Tumor Types to Be Featured at ESMO 2026

Summit Therapeutics announced that ivonescimab data will be presented at ESMO 2026, showcasing findings from various tumor types. Notably, positive survival results from the Phase III HARMONi-GI1 study in advanced biliary tract cancer were highlighted. The company aims to expand ivonescimab's clinical development across multiple indications.

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SMMT
Oct 21, 2026
SMMTPhases

Akeso Announces Summit Therapeutics and ECOG-ACRIN Cancer Research Group Enter into Phase II/III Clinical Trial Collaboration to Evaluate Ivonescimab in First-Line Biliary Tract Cancer

Akeso announced that Summit Therapeutics has partnered with ECOG-ACRIN for a Phase II/III trial evaluating ivonescimab in first-line biliary tract cancer. This study, EA2251, aims to compare ivonescimab with chemotherapy against existing immunotherapy standards. The trial follows positive results from a previous Phase III study, signaling potential advancements in treatment options.

Read more →
SMMT
Oct 21, 2026
SMMTPhases

Summit Therapeutics and ECOG-ACRIN Cancer Research Group Enter into Phase II / III Clinical Trial Collaboration to Evaluate Ivonescimab in First-Line Biliary Tract Cancer

Summit Therapeutics announced a collaboration with ECOG-ACRIN to conduct a Phase II/III trial evaluating ivonescimab in first-line biliary tract cancer. The study, EA2251, will compare ivonescimab with chemotherapy against established immunotherapy options. Clinical trial site activations are expected to begin in Q4 2026, aiming to address significant unmet needs in this aggressive cancer type.

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SMMT
Oct 19, 2026
SMMTPhases
▲ +6.4%on this newsshared move

Summit Therapeutics Announces Opening of Global Phase II Study of Ivonescimab-Based Regimens in Advanced Clear Cell Renal Cell Carcinoma

Summit Therapeutics has launched a global Phase II study of ivonescimab for treating advanced clear cell renal cell carcinoma (ccRCC). This randomized, open-label study will evaluate ivonescimab alone and in combination with other therapies in previously untreated patients. Conducted in partnership with Akeso, the trial aims to enroll around 100 patients across the U.S. and China.

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SMMT
Oct 5, 2026
SMMTGeneral

AstraZeneca Completes $2 Billion Equity Investment in Summit Therapeutics

Summit Therapeutics has successfully closed a $2 billion equity investment from AstraZeneca. This funding will aid in the development of ivonescimab, a promising investigational bispecific antibody targeting PD-1 and VEGF. The partnership is expected to bolster Summit's research capabilities and accelerate the drug's progress towards clinical use.

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SMMT
Oct 2, 2026
SMMTPhases

Summit Therapeutics Announces Clinical Trial Collaboration with AstraZeneca and Daiichi Sankyo to Evaluate Ivonescimab in Combination with TROP2-Directed ADC Datroway

Summit Therapeutics has entered a clinical trial collaboration with Daiichi Sankyo and AstraZeneca to assess ivonescimab, a PD-1/VEGF bispecific antibody. This partnership aims to evaluate the drug in combination with Datroway, a TROP2-directed ADC, across various solid tumors, including breast and lung cancer. The collaboration signifies a strategic move to advance cancer treatment options.

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SMMT
Sep 28, 2026
SMMTGeneral
▲ +5.9%on this newsshared move

AstraZeneca Makes $2 Billion Strategic Equity Investment in Summit Therapeutics

Summit Therapeutics has secured a $2 billion strategic equity investment from AstraZeneca, aimed at advancing cancer treatment initiatives. This collaboration will focus on the development of ivonescimab and sonesitatug vedotin. The partnership is expected to significantly enhance Summit's research capabilities and market presence in oncology.

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SMMT
Sep 22, 2026
SMMTPhases

HARMONi-GI1, a Phase III Trial Featuring Ivonescimab Plus Chemotherapy Compared to Durvalumab Plus Chemotherapy in First-Line Treatment of Patients with Advanced Biliary Tract Cancer from China, to Be Showcased in Presidential Symposium at ESMO 2026

The Phase III HARMONi-GI1 trial, conducted in China, has shown that ivonescimab combined with chemotherapy significantly improves overall survival compared to durvalumab plus chemotherapy in patients with advanced biliary tract cancer. The results will be presented at the ESMO 2026 Congress, showcasing the potential of ivonescimab as a first-in-class treatment. This study marks a significant advancement in the treatment landscape for this patient population.

Read more →
SMMT
Sep 15, 2026
SMMTPhases
▼ -5.5%on this news

Updated HARMONi Data Presented at WCLC 2026 Demonstrate Consistent Overall Survival Results with Ivonescimab Plus Chemotherapy in Western and Asian Patients

Summit Therapeutics presented updated overall survival results from the Phase III HARMONi trial at WCLC 2026. The trial showed that ivonescimab combined with chemotherapy significantly improved overall survival in both Western and Asian patients with EGFR-mutated non-small cell lung cancer. The results demonstrated consistency across geographic regions, with no new safety concerns noted.

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SMMT
Sep 13, 2026
SMMTPhases

Ivonescimab Monotherapy Demonstrates a Statistically Significant & Clinically Meaningful Benefit Compared to Pembrolizumab Monotherapy in PD-L1-Positive Advanced NSCLC in Akeso’s HARMONi-2 Study Conducted in China

The HARMONi-2 study revealed that ivonescimab monotherapy significantly improves overall survival in patients with PD-L1-positive advanced NSCLC compared to pembrolizumab. The trial showed a median overall survival increase of 8.2 months, with a hazard ratio of 0.73. The results were presented at the IASLC 2026 World Conference, highlighting ivonescimab's potential as a next-generation immuno-oncology therapy.

Read more →
SMMT
Sep 2, 2026
SMMTPhases
▲ +17.3%on this news

Ivonescimab Monotherapy Demonstrates Statistically Significant Overall Survival Benefit Compared to Pembrolizumab Monotherapy in PD-L1-Positive Advanced NSCLC in HARMONi-2 Study Conducted by Akeso in China

Summit Therapeutics' partner Akeso announced that ivonescimab monotherapy significantly improved overall survival compared to pembrolizumab in the Phase III HARMONi-2 study for PD-L1-positive advanced NSCLC. The study, conducted in China, demonstrated positive results that will be presented at a medical conference. Ivonescimab is currently approved in China but remains investigational in other regions.

Read more →
SMMT
Aug 25, 2026
SMMTPhases
▲ +6.5%on this news

Ivonescimab Plus Chemotherapy Demonstrates Statistically Significant Overall Survival Benefit Compared to Durvalumab Plus Chemotherapy in First-Line Advanced Biliary Tract Cancer in Single-Region Trial Conducted by Akeso in China

Summit Therapeutics' partner Akeso announced positive results from the Phase III HARMONi-GI1 study, showing that ivonescimab plus chemotherapy significantly improves overall survival compared to durvalumab plus chemotherapy in advanced biliary tract cancer. This trial is notable for being the first to demonstrate such superiority in this indication. Detailed results will be shared at an upcoming medical congress.

Read more →
SMMT
Aug 25, 2026
SMMTPhases

Ivonescimab Plus Chemotherapy Global Phase III HARMONi Primary Analysis Results Published in The Lancet Oncology

Summit Therapeutics has published primary analysis results from the Phase III HARMONi trial in The Lancet Oncology, showing that ivonescimab combined with chemotherapy significantly improves progression-free survival in patients with EGFR-mutated non-small cell lung cancer after third-generation EGFR TKI progression. The study involved 114 cancer centers globally and demonstrated a median PFS of 6.8 months compared to 4.4 months for the placebo group. Although the overall survival trend was positive, it did not reach statistical significance at this stage.

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SMMT
Aug 12, 2026
SMMTFDA Updates

Ivonescimab in Combination with Chemotherapy Approved in China by NMPA for First-Line Treatment of Patients with Squamous Non-Small Cell Lung Cancer

Summit Therapeutics announced that the National Medical Products Administration (NMPA) in China has approved ivonescimab in combination with chemotherapy for first-line treatment of advanced squamous non-small cell lung cancer (NSCLC). This approval is based on the successful HARMONi-6 clinical trial, which demonstrated significant improvements in overall and progression-free survival compared to existing treatments. This marks the third approval for ivonescimab in China, highlighting its potential as a leading therapy in oncology.

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SMMT
Aug 5, 2026
SMMTPhases

Summit Therapeutics Further Expands Ivonescimab Global Development Program with Phase II/III HARMONi-GU1 Study in 1L Bladder Cancer

Summit Therapeutics has announced the launch of the Phase II/III HARMONi-GU1 trial, expanding its clinical development program for ivonescimab in bladder cancer. This global study aims to evaluate the efficacy of ivonescimab in combination with an antibody-drug conjugate. The trial represents a significant step in the treatment of urothelial carcinoma.

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SMMT
Jul 23, 2026
SMMTGeneral
▼ -8.8%on this news

Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2026

Summit Therapeutics Inc. reported its financial results for Q2 and the first half of 2026, highlighting significant operational advancements. The company emphasized the clinical progress of ivonescimab, particularly following promising results from the HARMONi-6 Phase III study. These developments are expected to strengthen their position in the market.

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SMMT
Jul 22, 2026
SMMTPhases

Ivonescimab Plus Chemotherapy Shows Consistent, Favorable Overall Survival Results in Western and Asian Patients in Updated Analysis from Global Phase III HARMONi Study

Summit Therapeutics Inc. has reported updated overall survival results from the Phase III HARMONi trial, demonstrating that ivonescimab combined with platinum-doublet chemotherapy continues to show a favorable trend. The results indicate consistent efficacy and safety across both Asian and western patient populations compared to chemotherapy alone.

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SMMT
Jul 16, 2026
SMMTConferences/Events
▼ -8.7%on this news

Summit Therapeutics to Host Second Quarter 2026 Financial Results & Operational Progress Call on July 23, 2026

Summit Therapeutics Inc. will host a conference call on July 23, 2026, to discuss its second quarter financial results and operational updates. The call is set for 4:30 p.m. EDT and will be accessible via the company's website. This event highlights the company's commitment to investor relations and transparency.

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About Summit Therapeutics Inc.

Miami, FL 265 employees smmttx.com
Headquarters601 BRICKELL KEY DRIVE, MIAMI, FL, 33131
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