Financials
Cash Data
- Monthly Burn
- Burn Trend
- Dilution Risk
- SEC Filing
Key Stats
Upcoming Catalysts
FDA decisions, readouts and PDUFA dates · scored by probability of approval
SMMT Catalyst Timeline
Dated clinical, regulatory and corporate events for Summit Therapeutics Inc.
Catalyst Timeline
Dated clinical, regulatory & corporate events for Summit Therapeutics Inc.
Upcoming catalysts 2
Event history 50
Past FDA Catalysts and PDUFA Decisions
How SMMT actually traded into and out of each decision
| Date | Drug | Catalyst | Stage | Reaction | Event Move % | Best Trade % |
|---|---|---|---|---|---|---|
| 2026-10-25 | Ivonescimab (AK112) | Phase 1b/2 data presentation | Phase 1b/2 |
Drug Pipeline Intelligence
| Drug | Indication | Phase | PTRS | rNPV | Status | Enroll | Velocity | Design | Est. Completion | ML Signal | Last Change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ivonescimab Monoclonal antibodyNCT05899608 | Non Small Cell Lung Cancer | Phase 3 | ACTIVE NOT_RECRUITING | 2,538 | Dec 31, 2029 | ||||||
| Ivonescimab Monoclonal antibodyNCT05382442 | Metastatic Colorectal Cancer | Phase 3 | ACTIVE NOT_RECRUITING | 984 | Aug 12, 2028 | ||||||
| Ivonescimab Monoclonal antibodyNCT07815665 | Metastatic Urothelial Carcinoma | Phase 2 | RECRUITING | 800 | Dec 31, 2030 | ||||||
| Ivonescimab combined with Cadonilimab Monoclonal antibodyNCT07877194 | Renal Cell Carcinoma, Clear Cell | Phase 2 | NOT YET_RECRUITING | 100 | Dec 12, 2029 | ||||||
| Ivonescimab Monoclonal antibodyNCT06396065 | Non-Squamous Non-small Cell Lung Cancer | NDA/BLA | ACTIVE NOT_RECRUITING | 420 | Dec 31, 2026 |
Clinical Trial Results
Readouts, endpoints and source filings for every SMMT program
| Drug Name | Indication | Phase | Date | Trial Results Summary | Title | Source |
|---|---|---|---|---|---|---|
| ivonescimab | advanced biliary tract cancer | Phase 3 | 2026-10-25 | overall survival superiorityRead More | Ivonescimab Plus Chemotherapy Demonstrates Overall Survival Superiority Compared to Durvalumab Plus Chemotherapy in First-Line Treatment of Patients with Advanced Biliary Tract Cancer in HARMONi-GI1 Study Conducted by Akeso in ChinaRead More |
Inside Trades
| Insider | Side | Shares | Price | Value | Date |
|---|---|---|---|---|---|
| DUGGAN ROBERT WDirector, Officer (Co-Chief Executive Officer), 10% Owner | Buy | 3,810,000 573,883,879 held | $13.12 | 06/12/2026 |
Hedge Fund 13F Activity
Hedge Funds invested in SMMT
| Fund | % of Portfolio | Current MV | Shares Owned | Activity |
|---|---|---|---|---|
| BAKER BROS. ADVISORS | 2.4 % (-40 %) | 477.70 M | 32.79 M | -9.91% ( -3.60 M) |
SMMT Institutional Ownership Trends
SMMT Short Interest
Shares sold short, counted twice a month.
Options Data
Option Volume
Option Chain Statistics
| Expiry | Call Vol | Put Vol | Vol P/C | Call OI | Put OI | OI P/C | IV Call | IV Call OI-Wtd | IV Call Vol-Wtd | IV Put | IV Put OI-Wtd | IV Put Vol-Wtd |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-10-30 | ||||||||||||
Real-Time Option Chain
| Calls | Strike | Puts | ||||
|---|---|---|---|---|---|---|
| Last | Vol | OI | Last | Vol | OI | |
| No data available | ||||||
Calls vs Puts by Expiry
Competitive positioning
How SMMT ranks across every disease it competes in
SMMT News
Ivonescimab Plus Chemotherapy Demonstrates Overall Survival Superiority Compared to Durvalumab Plus Chemotherapy in First-Line Treatment of Patients with Advanced Biliary Tract Cancer in HARMONi-GI1 Study Conducted by Akeso in China
Summit Therapeutics' partner Akeso announced that ivonescimab plus chemotherapy demonstrated a statistically significant overall survival benefit compared to durvalumab plus chemotherapy in the Phase III HARMONi-GI1 study for advanced biliary tract cancer. The study showed a 25% reduction in the risk of death, with a median overall survival of 14.9 months for ivonescimab versus 12.1 months for durvalumab.
Read more →Summit Therapeutics and Lunit Announce Agreement to Apply AI-powered SCOPE IO Platform for Tumor Microenvironment Analysis in Immuno-Oncology Development
Summit Therapeutics and Lunit have entered a research agreement to utilize Lunit's AI-powered SCOPE IO platform for tumor microenvironment analysis. This partnership aims to support Summit's immuno-oncology programs, particularly with the investigational drug ivonescimab. The collaboration seeks to leverage AI to enhance biomarker discovery and patient selection in cancer therapies.
Read more →Ivonescimab Data Sets across Multiple Tumor Types to Be Featured at ESMO 2026
Summit Therapeutics announced that ivonescimab data will be presented at ESMO 2026, showcasing findings from various tumor types. Notably, positive survival results from the Phase III HARMONi-GI1 study in advanced biliary tract cancer were highlighted. The company aims to expand ivonescimab's clinical development across multiple indications.
Read more →Akeso Announces Summit Therapeutics and ECOG-ACRIN Cancer Research Group Enter into Phase II/III Clinical Trial Collaboration to Evaluate Ivonescimab in First-Line Biliary Tract Cancer
Akeso announced that Summit Therapeutics has partnered with ECOG-ACRIN for a Phase II/III trial evaluating ivonescimab in first-line biliary tract cancer. This study, EA2251, aims to compare ivonescimab with chemotherapy against existing immunotherapy standards. The trial follows positive results from a previous Phase III study, signaling potential advancements in treatment options.
Read more →Summit Therapeutics and ECOG-ACRIN Cancer Research Group Enter into Phase II / III Clinical Trial Collaboration to Evaluate Ivonescimab in First-Line Biliary Tract Cancer
Summit Therapeutics announced a collaboration with ECOG-ACRIN to conduct a Phase II/III trial evaluating ivonescimab in first-line biliary tract cancer. The study, EA2251, will compare ivonescimab with chemotherapy against established immunotherapy options. Clinical trial site activations are expected to begin in Q4 2026, aiming to address significant unmet needs in this aggressive cancer type.
Read more →Summit Therapeutics Announces Opening of Global Phase II Study of Ivonescimab-Based Regimens in Advanced Clear Cell Renal Cell Carcinoma
Summit Therapeutics has launched a global Phase II study of ivonescimab for treating advanced clear cell renal cell carcinoma (ccRCC). This randomized, open-label study will evaluate ivonescimab alone and in combination with other therapies in previously untreated patients. Conducted in partnership with Akeso, the trial aims to enroll around 100 patients across the U.S. and China.
Read more →AstraZeneca Completes $2 Billion Equity Investment in Summit Therapeutics
Summit Therapeutics has successfully closed a $2 billion equity investment from AstraZeneca. This funding will aid in the development of ivonescimab, a promising investigational bispecific antibody targeting PD-1 and VEGF. The partnership is expected to bolster Summit's research capabilities and accelerate the drug's progress towards clinical use.
Read more →Summit Therapeutics Announces Clinical Trial Collaboration with AstraZeneca and Daiichi Sankyo to Evaluate Ivonescimab in Combination with TROP2-Directed ADC Datroway
Summit Therapeutics has entered a clinical trial collaboration with Daiichi Sankyo and AstraZeneca to assess ivonescimab, a PD-1/VEGF bispecific antibody. This partnership aims to evaluate the drug in combination with Datroway, a TROP2-directed ADC, across various solid tumors, including breast and lung cancer. The collaboration signifies a strategic move to advance cancer treatment options.
Read more →AstraZeneca Makes $2 Billion Strategic Equity Investment in Summit Therapeutics
Summit Therapeutics has secured a $2 billion strategic equity investment from AstraZeneca, aimed at advancing cancer treatment initiatives. This collaboration will focus on the development of ivonescimab and sonesitatug vedotin. The partnership is expected to significantly enhance Summit's research capabilities and market presence in oncology.
Read more →HARMONi-GI1, a Phase III Trial Featuring Ivonescimab Plus Chemotherapy Compared to Durvalumab Plus Chemotherapy in First-Line Treatment of Patients with Advanced Biliary Tract Cancer from China, to Be Showcased in Presidential Symposium at ESMO 2026
The Phase III HARMONi-GI1 trial, conducted in China, has shown that ivonescimab combined with chemotherapy significantly improves overall survival compared to durvalumab plus chemotherapy in patients with advanced biliary tract cancer. The results will be presented at the ESMO 2026 Congress, showcasing the potential of ivonescimab as a first-in-class treatment. This study marks a significant advancement in the treatment landscape for this patient population.
Read more →Updated HARMONi Data Presented at WCLC 2026 Demonstrate Consistent Overall Survival Results with Ivonescimab Plus Chemotherapy in Western and Asian Patients
Summit Therapeutics presented updated overall survival results from the Phase III HARMONi trial at WCLC 2026. The trial showed that ivonescimab combined with chemotherapy significantly improved overall survival in both Western and Asian patients with EGFR-mutated non-small cell lung cancer. The results demonstrated consistency across geographic regions, with no new safety concerns noted.
Read more →Ivonescimab Monotherapy Demonstrates a Statistically Significant & Clinically Meaningful Benefit Compared to Pembrolizumab Monotherapy in PD-L1-Positive Advanced NSCLC in Akeso’s HARMONi-2 Study Conducted in China
The HARMONi-2 study revealed that ivonescimab monotherapy significantly improves overall survival in patients with PD-L1-positive advanced NSCLC compared to pembrolizumab. The trial showed a median overall survival increase of 8.2 months, with a hazard ratio of 0.73. The results were presented at the IASLC 2026 World Conference, highlighting ivonescimab's potential as a next-generation immuno-oncology therapy.
Read more →Ivonescimab Monotherapy Demonstrates Statistically Significant Overall Survival Benefit Compared to Pembrolizumab Monotherapy in PD-L1-Positive Advanced NSCLC in HARMONi-2 Study Conducted by Akeso in China
Summit Therapeutics' partner Akeso announced that ivonescimab monotherapy significantly improved overall survival compared to pembrolizumab in the Phase III HARMONi-2 study for PD-L1-positive advanced NSCLC. The study, conducted in China, demonstrated positive results that will be presented at a medical conference. Ivonescimab is currently approved in China but remains investigational in other regions.
Read more →Ivonescimab Plus Chemotherapy Demonstrates Statistically Significant Overall Survival Benefit Compared to Durvalumab Plus Chemotherapy in First-Line Advanced Biliary Tract Cancer in Single-Region Trial Conducted by Akeso in China
Summit Therapeutics' partner Akeso announced positive results from the Phase III HARMONi-GI1 study, showing that ivonescimab plus chemotherapy significantly improves overall survival compared to durvalumab plus chemotherapy in advanced biliary tract cancer. This trial is notable for being the first to demonstrate such superiority in this indication. Detailed results will be shared at an upcoming medical congress.
Read more →Ivonescimab Plus Chemotherapy Global Phase III HARMONi Primary Analysis Results Published in The Lancet Oncology
Summit Therapeutics has published primary analysis results from the Phase III HARMONi trial in The Lancet Oncology, showing that ivonescimab combined with chemotherapy significantly improves progression-free survival in patients with EGFR-mutated non-small cell lung cancer after third-generation EGFR TKI progression. The study involved 114 cancer centers globally and demonstrated a median PFS of 6.8 months compared to 4.4 months for the placebo group. Although the overall survival trend was positive, it did not reach statistical significance at this stage.
Read more →Ivonescimab in Combination with Chemotherapy Approved in China by NMPA for First-Line Treatment of Patients with Squamous Non-Small Cell Lung Cancer
Summit Therapeutics announced that the National Medical Products Administration (NMPA) in China has approved ivonescimab in combination with chemotherapy for first-line treatment of advanced squamous non-small cell lung cancer (NSCLC). This approval is based on the successful HARMONi-6 clinical trial, which demonstrated significant improvements in overall and progression-free survival compared to existing treatments. This marks the third approval for ivonescimab in China, highlighting its potential as a leading therapy in oncology.
Read more →Summit Therapeutics Further Expands Ivonescimab Global Development Program with Phase II/III HARMONi-GU1 Study in 1L Bladder Cancer
Summit Therapeutics has announced the launch of the Phase II/III HARMONi-GU1 trial, expanding its clinical development program for ivonescimab in bladder cancer. This global study aims to evaluate the efficacy of ivonescimab in combination with an antibody-drug conjugate. The trial represents a significant step in the treatment of urothelial carcinoma.
Read more →Summit Therapeutics Reports Financial Results and Operational Progress for the Second Quarter and Six Months Ended June 30, 2026
Summit Therapeutics Inc. reported its financial results for Q2 and the first half of 2026, highlighting significant operational advancements. The company emphasized the clinical progress of ivonescimab, particularly following promising results from the HARMONi-6 Phase III study. These developments are expected to strengthen their position in the market.
Read more →Ivonescimab Plus Chemotherapy Shows Consistent, Favorable Overall Survival Results in Western and Asian Patients in Updated Analysis from Global Phase III HARMONi Study
Summit Therapeutics Inc. has reported updated overall survival results from the Phase III HARMONi trial, demonstrating that ivonescimab combined with platinum-doublet chemotherapy continues to show a favorable trend. The results indicate consistent efficacy and safety across both Asian and western patient populations compared to chemotherapy alone.
Read more →Summit Therapeutics to Host Second Quarter 2026 Financial Results & Operational Progress Call on July 23, 2026
Summit Therapeutics Inc. will host a conference call on July 23, 2026, to discuss its second quarter financial results and operational updates. The call is set for 4:30 p.m. EDT and will be accessible via the company's website. This event highlights the company's commitment to investor relations and transparency.
Read more →