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recombinant interferon alpha-1b

Phase 1

Breast Cancer | Monoclonal antibody | Oncology |Community Health Systems, Inc.|Last Updated: Oct 14, 2015

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment35

FDA Designations

No designations recorded

Clinical trial landscape

recombinant interferon alpha-1b · 1 trial · 7 indications

Phase 1 1
NCT00276536Interferon Alfa in Treating Patients With Stage IV Solid Tumors, Lymphoma, or MyelomaBreast Cancer
COMPLETED35 Analytics
PHASE1COMPLETED
Interferon Alfa in Treating Patients With Stage IV Solid Tumors, Lymphoma, or Myeloma
Breast CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Tolerance and safety as measured by any ≥ Grade IV granulocyte toxicity or any Grade III toxicity thought to be drug related at 1 week after each course
3 years
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
TreatmentEXPERIMENTALIFN weekly

Interventions

NameTypeDescription
recombinant interferon alpha-1bBIOLOGICALinterferon
IFNDRUGIFN daily
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Eligibility Criteria

Age Range18 Years to 120 Years
SexALL
Healthy VolunteersNo
Study Sites1

DISEASE CHARACTERISTICS: * Histologically confirmed malignancy, including, but not limited to, renal cell carcinoma, melanoma, Kaposi's sarcoma, breast carcinoma, lymphoma, myeloma, or tumors of endothelial origin * Stage IV disease * Refractory to standard therapy * Measurable or evaluable di...

Countries:United States
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Competitive Landscape -Breast Cancer 402 trials

Top 20 of 92 competitors

CompanyTickerTrialsLead PhaseDrugs
AstraZeneca PLCAZN47PHASE3Fulvestrant, Capivasertib
Merck & Co., Inc.MRK12PHASE3Pembrolizumab, Paclitaxel, Doxorubicin, Epirubicin, Cyclophosphamide
Eli Lilly and CompanyLLY27PHASE3Abemaciclib, Standard Adjuvant Endocrine Therapy
BioNTech SE Sponsored ADRBNTX7PHASE3DB-1303/BNT323, T-DM1
Gilead Sciences, Inc.GILD13PHASE3Sacituzumab Govitecan-hziy, Eribulin, Capecitabine Product, Gemcitabine, Vinorelbine
Novartis AG Sponsored ADRNVS30PHASE3Ribociclib
Pfizer Inc.PFE34PHASE3ARV-471, Fulvestrant
BeOne Medicines Ltd. Sponsored ADRONC5PHASE3BGB-43395, Letrozole, Abemaciclib, Palbociclib, Ribociclib
Olema Pharmaceuticals, Inc.OLMA5PHASE3Palazestrant, Fulvestrant, Anastrozole, Letrozole, Exemestane
Jazz Pharmaceuticals Public Limited CompanyJAZZ3PHASE3Zanidatamab, Trastuzumab, Eribulin, Vinorelbine, Gemcitabine
Celcuity Inc.CELC3PHASE3Gedatolisib, Palbociclib, Fulvestrant, Alpelisib
Relay Therapeutics, Inc.RLAY2PHASE3Zovegalisib, Capivasertib, Fulvestrant
GSK plc Sponsored ADRGSK2PHASE3Niraparib
Greenwich LifeSciences, Inc.GLSI1PHASE3GLSI-100
Bristol-Myers Squibb CompanyBMY5PHASE2Iza-bren, Nab-paclitaxel, Paclitaxel, Capecitabine, Carboplatin
BriaCell Therapeutics CorpBCTX2PHASE3SV-BR-1-GM, Cyclophosphamide, Interferon infiltration of the inoculation site, Retifanlimab, Treatment of Physician's Choice
Incyte CorporationINCY4PHASE2Ruxolitinib, Capecitabine, Regorafenib
Natera, Inc.NTRA3PHASE2Discontinuation of the anti-HER2 maintenance therapy
Puma Biotechnology, Inc.PBYI3PHASE2Neratinib, Loperamide, Colesevelam
Atossa Therapeutics, Inc.ATOS1PHASE2endoxifen, goserelin
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Frequently asked questions about recombinant interferon alpha-1b

What is recombinant interferon alpha-1b used for in breast cancer?

Recombinant interferon alpha-1b is an investigational biologic being studied for the treatment of breast cancer. It is a monoclonal antibody modality under development by Community Health Systems, Inc. (CYH). The drug is currently in Phase 1 clinical development for oncology indications, including breast cancer.

What does recombinant interferon alpha-1b target?

Recombinant interferon alpha-1b is a monoclonal antibody modality. Its specific molecular target has not been disclosed. The drug is being evaluated in a Phase 1 clinical trial for patients with advanced solid tumors, including breast cancer, to assess its safety and potential antitumor activity.

Who makes recombinant interferon alpha-1b?

Recombinant interferon alpha-1b is being developed by Community Health Systems, Inc., which trades under the ticker CYH. The company is conducting clinical research on this investigational drug for oncology indications, including breast cancer.

What phase is recombinant interferon alpha-1b in?

Recombinant interferon alpha-1b is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. One Phase 1 trial has been completed, involving 35 patients with advanced solid tumors, lymphoma, or myeloma.

What clinical trials is recombinant interferon alpha-1b in?

Recombinant interferon alpha-1b has one completed clinical trial, NCT00276536, titled 'Interferon Alfa in Treating Patients With Stage IV Solid Tumors, Lymphoma, or Myeloma.' This Phase 1 study enrolled 35 patients in the United States and included conditions such as breast cancer, kidney cancer, lymphoma, melanoma, and multiple myeloma.

Is recombinant interferon alpha-1b the same as interferon alfa?

Recombinant interferon alpha-1b is a form of interferon alfa, as indicated by the clinical trial title 'Interferon Alfa in Treating Patients With Stage IV Solid Tumors, Lymphoma, or Myeloma.' It is an investigational recombinant version of interferon alpha being studied for its antitumor effects in advanced cancers.