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Tesaglitazar

Phase 2

Type 2 Diabetes | Small molecule | Metabolic |AstraZeneca PLC|Last Updated: Jul 31, 2006

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment500

FDA Designations

No designations recorded

Clinical trial landscape

Tesaglitazar · 1 trial · 1 indication

Phase 2 1
NCT00280865GLAD: Dose-Finding, Efficacy, and Safety of AZ 242 (Tesaglitazar) in Subjects With Type 2 DiabetesType 2 Diabetes
COMPLETED500 Analytics
PHASE2COMPLETED
GLAD: Dose-Finding, Efficacy, and Safety of AZ 242 (Tesaglitazar) in Subjects With Type 2 Diabetes
Type 2 DiabetesUnlock trial analytics

Study Endpoints

Primary Endpoints

Absolute change from baseline to end of randomized treatment period in fasting plasma glucose (FPG)

Secondary Endpoints

Changes in the following variables from baseline to the end of the randomized treatment period:
The change in plasma glucose and insulin during an oral glucose tolerance test
Insulin sensitivity by assessment of change in the calculated variable homeostasis assessment model
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
TesaglitazarDRUG -
PioglitazoneDRUG -
Dietary and Lifestyle Modification CounselingBEHAVIORAL -
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Eligibility Criteria

Age Range30 Years to 50 Years
SexALL
Healthy VolunteersNo
Study Sites110

Inclusion Criteria: * Provision of a written informed consent * Men or women who are 30 to 80 years of age * Female patients: postmenopausal or surgically sterile * Diagnosed with type 2 diabetes with C-peptide levels \> 0.8 ng/mL * Treated with diet alone or treatment with a single oral antidiabet...

Countries:United StatesCanadaFranceMexico
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Frequently asked questions about Tesaglitazar

What is Tesaglitazar used for?

Tesaglitazar is an investigational small molecule being studied for the treatment of Type 2 Diabetes. It is a metabolic therapeutic agent developed by AstraZeneca PLC. As of the available data, it is in Phase 2 clinical development and has not been approved for any use.

What does Tesaglitazar target?

Tesaglitazar is a small molecule developed for Type 2 Diabetes. The specific molecular target or target class has not been disclosed in the available information. Therefore, its mechanism of action is not detailed here.

Who makes Tesaglitazar?

Tesaglitazar is being developed by AstraZeneca PLC, a pharmaceutical company listed on the stock exchange under the ticker AZN. The drug is currently in Phase 2 clinical trials for Type 2 Diabetes.

What phase is Tesaglitazar in?

Tesaglitazar is in Phase 2 clinical development. It is an investigational drug and has not been approved by regulatory authorities. One Phase 2 trial has been completed, and there are no active trials currently listed for this asset.

What clinical trials is Tesaglitazar in?

Tesaglitazar has one completed clinical trial registered under NCT00280865, titled 'GLAD: Dose-Finding, Efficacy, and Safety of AZ 242 (Tesaglitazar) in Subjects With Type 2 Diabetes.' This Phase 2 study enrolled 500 participants across the United States, Canada, France, and Mexico.

Is Tesaglitazar the same as AZ 242?

Yes, Tesaglitazar is also known as AZ 242. The clinical trial NCT00280865 refers to the drug as AZ 242 (Tesaglitazar), confirming that these names refer to the same investigational compound.