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Anastrazole

Phase 2

Breast Cancer | Small molecule | Oncology |AstraZeneca PLC|Trials Updated: Apr 23, 2009

Anastrazole development status

Highest phase Phase 2
Registered trials 4 across 3 sponsors since Nov 2005

Anastrazole target and mechanism

ModalitySmall molecule

Also known as Anastrazole (Arimidex)

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLEDBiomarker
Total Trials1
Total Enrollment185

FDA Designations

No designations recorded

Anastrazole clinical trials

Anastrazole · 1 trial · 1 indication

Phase 2 1
NCT00255463Phase II Neoadjuvant ER+/PgR + Arimidex +/- Iressa StudyBreast Cancer
COMPLETED185 Analytics
PHASE2COMPLETED
Phase II Neoadjuvant ER+/PgR + Arimidex +/- Iressa Study
Breast CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

To determine and compare changes in proliferation marker at 16 weeks in the treatment groups

Secondary Endpoints

Tumour response, safety and tolerability, pharmacokinetics, pharmacokinetics and dynamics, oestradiol levels, mastectomy rate.
Comparison of WHO and RECIST criteria,
Exploratory biomarker studies involving genomics, metabolomics and proteomics.
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
AnastrazoleDRUG -
GefitinibDRUG -
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Eligibility Criteria

SexFEMALE
Healthy VolunteersNo
Study Sites34

Inclusion Criteria: * Measurable (stage I-IIIB) non meta static non inflammatory breast cancer * Patients must post menopausal women who in the opinion of investigator would be likely to benefit from endocrine therapy. Postmenopausal patients are defined as: * Natural menopause with last menses \> ...

Countries:CzechiaFranceHungaryPortugalSpainSwedenUnited Kingdom
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Competitive Landscape -Breast Cancer 609 trials

Frequently asked questions about Anastrazole

What is Anastrazole used for?

Anastrazole is used for breast cancer. It is a small molecule studied in a Phase 2 neoadjuvant setting for ER+/PgR+ breast cancer, meaning it was evaluated in patients with hormone receptor positive disease before surgery. The clinical program focused on biomarker-selected patients.

Who makes Anastrazole?

Anastrazole is developed by AstraZeneca PLC, which trades under the ticker AZN. AstraZeneca is the company associated with the clinical development of this small molecule in breast cancer.

What phase is Anastrazole in?

Anastrazole is in Phase 2 clinical development for breast cancer. The recorded trial is a completed Phase 2 study, and the drug remains investigational rather than approved. No active trials are currently listed for this asset.

What clinical trials is Anastrazole in?

Anastrazole has been studied in one completed Phase 2 trial, NCT00255463, titled Phase II Neoadjuvant ER+/PgR+ Arimidex +/- Iressa Study. It enrolled 185 female participants across Czechia, France, Hungary, Portugal, Spain, Sweden, and the United Kingdom.

Is Anastrazole the same as Arimidex?

Yes, Anastrazole is also known as Arimidex. The names refer to the same drug, and the Phase 2 trial NCT00255463 uses the Arimidex name in its title. Searches for either name point to the same AstraZeneca asset.