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Uridine 5'-Triphosphate

Phase 3

Lung Cancer | Small molecule | Oncology |Merck & Company, Inc.|Trials Updated: Sep 4, 2015

Uridine 5'-Triphosphate target and mechanism

ModalitySmall molecule

Also known as Uridine 5'-Triphosphate (UTP) Solution for Inhalation

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment700

FDA Designations

No designations recorded

Uridine 5'-Triphosphate clinical trials

Uridine 5'-Triphosphate · 1 trial · 1 indication

Phase 3 1
NCT00210080A Study to Diagnose Lung Cancer by Sputum Cytology (01-312)Lung Cancer
COMPLETED700 Analytics
PHASE3COMPLETED
A Study to Diagnose Lung Cancer by Sputum Cytology (01-312)
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Study Endpoints

Primary Endpoints

Proportion of lung cancers (malignancies) diagnosed by sputum cytology

Secondary Endpoints

Proportion of centrally and peripherally located lung cancers diagnosed by sputum cytology;
Proportion of small and large lung cancers diagnosed by sputum cytology;
Proportion of lung cancers of various cell types, stages and resectability diagnosed by sputum cytology;
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
Uridine 5'-Triphosphate (UTP) Solution for InhalationDRUG -
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Eligibility Criteria

Healthy VolunteersNo

Inclusion Criteria: * be suspected of having primary lung cancer based upon chest radiograph(s), CT scan(s), or PET scan(s) and with symptom, risk profile, or history suggestive of malignancy * have FEV1 greater than or equal to 40% predicted normal for age and height Exclusion Criteria: * have o...

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Competitive Landscape -Lung Cancer 400 trials

Top 20 of 75 competitors

CompanyTickerTrialsLead PhaseDrugs
AbbVie, Inc.ABBV5PHASE3Telisotuzumab Adizutecan, ABBV-706, ABBV-324
Merck & Co., Inc.MRK17PHASE3Pembrolizumab, Olaparib, Pembrolizumab Berahyaluronidase alfa, Ifinatamab Deruxtecan, Patritumab Deruxtecan
Gilead Sciences, Inc.GILD6PHASE3Sacituzumab govitecan, Domvanalimab, Quemliclustat, Zimberelimab, Etrumadenant
Amgen Inc.AMGN16PHASE3Tarlatamab, ABP 234
AstraZeneca PLCAZN38PHASE3Durvalumab, Tremelimumab, Volrustomig, Dato-DXd, Osimertinib
Bristol-Myers Squibb CompanyBMY17PHASE3Adagrasib, BMS-986489, Nivolumab, Ipilimumab, Navlimetostat
BioNTech SE Sponsored ADRBNTX6PHASE3Pumitamig, BNT324
Eli Lilly and CompanyLLY4PHASE3Ramucirumab, LY4175408
Pfizer Inc.PFE16PHASE3PF-08634404, PF-07104091, Prifetrastat, Palbociclib, PF-07220060
ArriVent BioPharma, Inc.AVBP6PHASE3Firmonertinib
BeOne Medicines Ltd. Sponsored ADRONC7PHASE3Tislelizumab, BGB-A445, LBL-007, BGB-15025, BGB-B2033
Revolution Medicines, Inc.RVMD3PHASE3Daraxonrasib, Zoldonrasib, Elironrasib
Zai Lab Ltd. Sponsored ADRZLAB4PHASE3ZL-1310
Summit Therapeutics IncSMMT1PHASE3Ivonescimab
Jazz Pharmaceuticals Public Limited CompanyJAZZ3PHASE3Lurbinectedin
Immutep Ltd Sponsored ADRIMMP2PHASE3eftilagimod alfa (efti / IMP321), IMP321
GSK plc Sponsored ADRGSK2PHASE3Risvutatug rezetecan
Regeneron Pharmaceuticals, Inc.REGN6PHASE2Cemiplimab, Fianlimab, Ubamatamab, Marlotamig
ImmunityBio IncIBRX2PHASE3Nogapendekin alfa inbakicept
Novartis AG Sponsored ADRNVS9PHASE2Opnurasib, Spartalizumab, Lutetium Lu 177 Dotatate, Gallium 68 Dotatate, TNO155
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Frequently asked questions about Uridine 5'-Triphosphate

What is Uridine 5'-Triphosphate for?

Uridine 5'-Triphosphate is being studied for lung cancer. It is an investigational small molecule developed by Merck & Company, Inc. (MRK) and has reached Phase 3 clinical development. It is not described as an approved therapy, and its only recorded trial in lung cancer has been completed.

Who makes Uridine 5'-Triphosphate?

Uridine 5'-Triphosphate is developed by Merck & Company, Inc., which trades under the ticker MRK. Merck is the sponsor associated with the Phase 3 program for this small molecule in lung cancer.

What phase is Uridine 5'-Triphosphate in?

Uridine 5'-Triphosphate is in Phase 3 development for lung cancer. One Phase 3 trial has been completed, and no trials are currently listed as active. The program is investigational and has not been described as FDA approved.

What clinical trials is Uridine 5'-Triphosphate in?

Uridine 5'-Triphosphate has been studied in one Phase 3 trial, NCT00210080, titled A Study to Diagnose Lung Cancer by Sputum Cytology (01-312). The trial enrolled 700 participants, was randomized and double blind, and its status is completed.

Is Uridine 5'-Triphosphate the same as Uridine 5'-Triphosphate (UTP) Solution for Inhalation?

Yes. Uridine 5'-Triphosphate is also known as Uridine 5'-Triphosphate (UTP) Solution for Inhalation. Both names refer to the same investigational small molecule being developed by Merck & Company, Inc. (MRK) for lung cancer.