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CX11

Phase 2

Obesity | Small molecule | Metabolic |Milestone Pharmaceuticals Inc.|Last Updated: Aug 20, 2026

Target and mechanism

ModalitySmall molecule

Also known as CX11 (VCT220)

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment250

FDA Designations

No designations recorded

Clinical trial landscape

CX11 · 3 trials · 4 indications

Phase 2 2Phase 1 1
NCT07340320A Study of CX11 Tablets in Patients With Type 2 Diabetes MellitusType II Diabetes Mellitus
RECRUITING240 Analytics
NCT07011797A Study to Evaluate the Efficacy and Safety of CX11 Tablets in Overweight/Obese ParticipantsObesity
COMPLETED250 Analytics
PHASE2RECRUITING
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
Type II Diabetes MellitusUnlock trial analytics
PHASE2COMPLETED
A Study to Evaluate the Efficacy and Safety of CX11 Tablets in Overweight/Obese Participants
ObesityUnlock trial analytics

Study Endpoints

Primary Endpoints

Change in Glycosylated hemoglobin, Type A1C (HbA1c) from baseline
At Week 24
Percentage change in body weight from baseline
At Week 26
Area Under the Concentration-time curve from 0 to 24 hour (AUC0-24) of CX11 (VCT220)
Predose at Day1 up to 35 days postdose

AUC0-24 of of CX11 (VCT220)

Maximum Observed Concentration (Cmax) of CX11 (VCT220)
Predose at Day1 up to 35 days postdose

Cmax of CX11 (VCT220)

Time to Maximum Observed Concentration (Tmax) of CX11 (VCT220)
Predose at Day 1 up to 35 days postdose

Tmax of CX11 (VCT220)

Secondary Endpoints

Proportion of participants achieving HbA1c < 7.0%
At Week 24
Proportion of participants achieving HbA1c ≤ 6.5%
At Week 24
Change from baseline in Time in Range (TIR) measured by Continuous Glucose Monitoring (CGM)
To Week 24
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Placebo groupPLACEBO_COMPARATOR -
40 mg groupEXPERIMENTAL -
80 mg groupEXPERIMENTAL -
120 mg groupEXPERIMENTAL -
160 mg groupEXPERIMENTAL -
200 mg groupEXPERIMENTAL -
200 mg fast titration groupEXPERIMENTAL -
200 mg slow titration groupEXPERIMENTAL -
Fasted-Fed ArmEXPERIMENTALFasted-Fed Group
Fed-Fasted ArmEXPERIMENTALFed-Fasted Group

Interventions

NameTypeDescription
CX11DRUGCX11 tablets administered orally once daily (QD)
PlaceboOTHERMatching placebo tablets administered orally once daily (QD)
CX11 (VCT220)DRUGCX11 (VCT220) administered orally to participants who are in fasted/fed state in the first 6 consecutive days, and in fed/fasted state on the 7th day
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites48

Inclusion Criteria Participants who meet all of the following criteria will be eligible to participate in this study: * Adults aged 18 to 75. * Diagnosis of type 2 diabetes for at least 6 months. * HbA1c between 7.0% and 10.5%. * Body mass index (BMI) between 23 and 50 kg/m². * Body weight stable ...

Countries:United StatesPolandChina
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Recent Changes (Last 90 Days)

MEDIUMAug 20, 2026NCT07340320primaryCompletionDate: changed
MEDIUMAug 20, 2026NCT07340320primaryCompletionDate: changed
MEDIUMAug 1, 2026NCT07011797TRIAL_REMOVED: changed
LOWAug 1, 2026NCT07340320primaryCompletionDate: changed
MEDIUMAug 1, 2026NCT07011797TRIAL_REMOVED: changed
LOWAug 1, 2026NCT07340320primaryCompletionDate: changed
MEDIUMAug 1, 2026NCT07011797TRIAL_REMOVED: changed
LOWAug 1, 2026NCT07340320primaryCompletionDate: changed

Frequently asked questions about CX11

What is CX11 used for?

CX11 is an investigational small molecule being developed for Type II Diabetes Mellitus, Obesity, and Obesity & Overweight. It is currently in Phase 2 clinical development for these metabolic conditions.

Who makes CX11?

CX11 is being developed by Milestone Pharmaceuticals Inc., a biopharmaceutical company traded on the stock exchange under the ticker MIST.

What phase is CX11 in?

CX11 is in Phase 2 clinical development. It is an investigational drug and has not been approved by regulatory authorities. Clinical trials are ongoing to evaluate its efficacy and safety.

What clinical trials is CX11 in?

CX11 is being studied in several trials. NCT07011797 is a completed Phase 2 study in overweight/obese participants. NCT07340320 is a recruiting Phase 2 trial in Type 2 Diabetes Mellitus. NCT07349381 is a recruiting Phase 1 food-effect study in healthy participants.

Is CX11 the same as CX11 (VCT220)?

Yes, CX11 is also known as CX11 (VCT220). Both names refer to the same investigational drug being developed by Milestone Pharmaceuticals Inc.

What is the mechanism of action of CX11?

The molecular target or target class for CX11 has not been disclosed in available information. Therefore, its specific mechanism of action is not described here.