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ISIS 3521

Phase 3

Lung Cancer | Monoclonal antibody | Oncology |Ionis Pharmaceuticals, Inc.|Last Updated: Dec 5, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment -
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00017407Carboplatin and Paclitaxel With or Without ISIS 3521 in Treating Patients With Non-Small Cell Lung CancerPHASE3 COMPLETED -Oct 13, 2000Sep 9, 2002Dec 5, 20222 United States
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Study Design & Arms
PurposeTREATMENT
Interventions
NameTypeDescription
ISIS 3521BIOLOGICAL -
carboplatinDRUG -
paclitaxelDRUG -
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Eligibility Criteria
Age Range18 Years — 120 Years
SexALL
Healthy VolunteersNo
Study Sites2

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed non-small cell lung cancer (NSCLC) Stage IV OR Stage IIIB with malignant pleural or pericardial effusion At least 1 unidimensionally measurable lesion At least 10 mm by spiral CT scan OR At least 20 mm by standard techniques OR Evalu...

Countries:United States
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Competitive Landscape -Lung Cancer 290 trials
CompanyTickerTrialsLead PhaseDrugs
Merck & Co., Inc.MRK10PHASE3Pembrolizumab, Olaparib, Etoposide /m^2, Pembrolizumab/Vibostolimab Co-Formulation, Etoposide
Gilead Sciences, Inc.GILD5PHASE3Sacituzumab Govitecan, Topotecan, Amrubicin, Lurbinectedin, Domvanalimab
Amgen Inc.AMGN14PHASE3Tarlatamab, Durvalumab, ABP 234, Pembrolizumab, Lurbinectedin
AstraZeneca PLCAZN32PHASE3Durvalumab, Tremelimumab, Volrustomig, Pembrolizumab, Carboplatin
BioNTech SE Sponsored ADRBNTX6PHASE3Pumitamig, Atezolizumab, Etoposide, Carboplatin, PM8002
Bristol-Myers Squibb CompanyBMY15PHASE3MRTX849, Docetaxel, BMS-986489, Atezolizumab, Carboplatin
Pfizer Inc.PFE13PHASE3PF-08634404, Pembrolizumab, Chemotherapy Regimen 1, PF-07220060, Letrozole
AbbVie, Inc.ABBV4PHASE3ABBV-706, Topotecan, Lurbinectedin, Amrubicin, Telisotuzumab Adizutecan
ArriVent BioPharma, Inc.AVBP6PHASE3furmonertinib , daily, platinum-based chemotherapy, Firmonertinib, JAB-21822, Tislelizumab
Eli Lilly and CompanyLLY3PHASE3Ramucirumab, Erlotinib, Gefitinib, Osimertinib, LY4175408
Jazz Pharmaceuticals Public Limited CompanyJAZZ3PHASE3Atezolizumab, Lurbinectedin, Carboplatin, Etoposide, Durvalumab
Summit Therapeutics IncSMMT1PHASE3AK112
Revolution Medicines, Inc.RVMD2PHASE3daraxonrasib, docetaxel, RMC-6291, RMC-6236, Pembrolizumab
Incyte CorporationINCY3PHASE3Retifanlimab, Pemetrexed, Cisplatin, Carboplatin, Paclitaxel
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK1PHASE3TAK-788, Pemetrexed, Cisplatin, Carboplatin
Regeneron Pharmaceuticals, Inc.REGN5PHASE2BNT116, Cemiplimab, Fianlimab, Pemetrexed, Paclitaxel
ImmunityBio IncIBRX3PHASE3Drug: Nogapendekin alfa inbakicept, Pembrolizumab, Cisplatin or Carboplatin, Nab-paclitaxel OR Pemetrexed, Nab-paclitaxel OR Paclitaxel OR Docetaxel
Immutep Ltd Sponsored ADRIMMP2PHASE3eftilagimod alfa, carboplatin plus paclitaxel, cisplatin or carboplatin + pemetrexed, pembrolizumab, IMP321
GSK plc Sponsored ADRGSK1PHASE3Ris-Rez, Topotecan
Zai Lab Ltd. Sponsored ADRZLAB2PHASE3ZL-1310, Atezolizumab, Carboplatin
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