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ICI 182, 780

Phase 2

Systemic Lupus Erythematosus | Small molecule | Immunology |AstraZeneca PLC|Last Updated: Sep 22, 2009

Target and mechanism

ModalitySmall molecule

Also known as ICI 182,780 (Faslodex)

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment20

FDA Designations

No designations recorded

Clinical trial landscape

ICI 182, 780 · 1 trial · 1 indication

Phase 2 1
NCT00417430Efficacy of Faslodex in Treatment of SLE Clinical, Serologic, and Molecular StudiesSystemic Lupus Erythematosus
COMPLETED20 Analytics
PHASE2COMPLETED
Efficacy of Faslodex in Treatment of SLE Clinical, Serologic, and Molecular Studies
Systemic Lupus ErythematosusUnlock trial analytics

Study Endpoints

Primary Endpoints

Improved SLEDAI
Improved Disease Lab parameters
Measurement of the estrogen receptors from start to finish
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
ICI 182,780 (Faslodex)DRUG -
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Eligibility Criteria

Age Range16 Years to 50 Years
SexFEMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Premenopausal women with SLE * Without life-threatening manifestations * With regular menstrual cyles not on hormones of any kind Exclusion Criteria: For any of the following: * Increase of SLEDAI greater than 12 * If life-threatening manifestations occur * If menstruation ...

Countries:United States
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Frequently asked questions about ICI 182, 780

What is ICI 182,780 used for?

ICI 182,780 is being studied for the treatment of systemic lupus erythematosus (SLE), an autoimmune disease. It is an investigational small molecule developed by AstraZeneca PLC under the ticker AZN. The drug has completed a Phase 2 clinical trial evaluating its efficacy in SLE patients.

Who is developing ICI 182,780?

ICI 182,780 is being developed by AstraZeneca PLC, which trades under the ticker AZN. The company sponsored a Phase 2 clinical trial of the drug in systemic lupus erythematosus. AstraZeneca is the sole developer listed for this asset.

What phase is ICI 182,780 in?

ICI 182,780 is in Phase 2 development. A Phase 2 clinical trial in systemic lupus erythematosus has been completed. The drug is investigational and has not been approved by the FDA for any indication.

What clinical trials is ICI 182,780 in?

ICI 182,780 has been evaluated in one completed Phase 2 clinical trial, NCT00417430, titled "Efficacy of Faslodex in Treatment of SLE Clinical, Serologic, and Molecular Studies." The trial enrolled 20 female participants aged 16 years and older in the United States and was randomized and double-blind.

Is ICI 182,780 the same as Faslodex?

Yes, ICI 182,780 is also known as Faslodex. The alternative name Faslodex appears in the title of its Phase 2 clinical trial in systemic lupus erythematosus. Both names refer to the same investigational small molecule developed by AstraZeneca PLC.