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Inebilizumab

Phase 3

Autoimmune Hepatitis | Small molecule | Infectious Disease |Amgen Inc.|Last Updated: May 20, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment180
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07598825A Trial of Inebilizumab in Participants With Autoimmune HepatitisPHASE3 NOT YET_RECRUITING 180Sep 7, 2026Feb 11, 2034May 20, 2026 -
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Study Endpoints
Primary Endpoints
Part 1: Number of Participants who Experienced Treatment-emergent Adverse Events (TEAEs), Serious TEAEs, and TEAEs of Interest at Week 26
Up to Week 26
Part 2: Number of Participants who Achieved Modified Histologic Activity Index (mHAI) ≤ 3 and Stable Prednisone Dose (or equivalent) ≤ 5 mg/day at Week 78
Week 78

Participants who met the two outcomes combined will be reported for this endpoint.

Secondary Endpoints
Part 1: Number of Participants who Achieved Normal Alanine Aminotransferase (ALT) Levels at Week 26
Week 26
Part 1: Change from Baseline in ALT Levels at Week 26
Baseline and Week 26
Part 1: Maximum Serum Concentration (Cmax) of Inebilizumab
Up to Week 26
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Part 1: InebilizumabEXPERIMENTALParticipants will receive inebilizumab as an intravenous (IV) infusion in addition to standard of care (SOC).
Part 1: PlaceboEXPERIMENTALParticipants will receive placebo as an IV infusion in addition to SOC.
Part 2: InebilizumabEXPERIMENTALParticipants will receive Inebilizumab as an IV infusion in addition to SOC.
Part 2: PlaceboEXPERIMENTALParticipants will receive placebo as an IV infusion in addition to SOC.
Interventions
NameTypeDescription
InebilizumabDRUGInebilizumab will be administered as an IV infusion.
PlaceboDRUGPlacebo will be administered as IV infusion.
Standard of CareOTHERStandard of Care
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Eligibility Criteria
Age Range18 Years — 74 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Signed informed consent. * Age ≥ 18 years or legal adult age within the country, whichever is older and \< 75 years at the time of signing the informed consent. * Participants must have either inadequate response to at least 9 months of SOC or are intolerant to SOC within 6 mo...

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Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT07598825studyFirstPostDate: changed
LOWMay 21, 2026NCT07598825NEW_TRIAL: changed
LOWMay 21, 2026NCT07598825NEW_TRIAL: changed