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VTX3232 Dose A

Phase 2

Obesity | Small molecule | Metabolic |Ventyx Biosciences, Inc.|Last Updated: Nov 10, 2025

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment176

FDA Designations

No designations recorded

Clinical trial landscape

VTX3232 Dose A · 1 trial · 1 indication

Phase 2 1
NCT06771115Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in ObesityObesity
COMPLETED176 Analytics
PHASE2COMPLETED
Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity
ObesityUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence Rate and Severity of Adverse Event (AE), Serious Adverse Event (SAE), and AEs leading to study treatment discontinuation through study completion
Day 1 of treatment period through study completion, up to 16 weeks

Incidence of AEs and SAEs and AEs leading to study treatment discontinuation

Secondary Endpoints

Change from baseline in hs-CRP level
Day 1 of treatment period to week 12 of treatment period
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
VTX3232 Dose AEXPERIMENTALVTX3232 Dose A
PlaceboPLACEBO_COMPARATORPlacebo
VTX3232 Dose A in combination with semaglutideEXPERIMENTALVTX3232 Dose A in combination with semaglutide
Placebo in combination with semaglutideEXPERIMENTALPlacebo in combination with semaglutide

Interventions

NameTypeDescription
VTX3232 Dose ADRUGVTX3232 Dose A
PlaceboDRUGPlacebo
VTX3232 Dose A in combination with semaglutideDRUGVTX3232 Dose A in combination with semaglutide
Placebo in combination with semaglutideDRUGPlacebo in combination with semaglutide
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Eligibility Criteria

Age Range18 Years to 80 Years
SexALL
Healthy VolunteersNo
Study Sites14

Inclusion Criteria: * Participants are male or female ≥ 18 years up to ≤ 80 years of age. * Ability to comply with study requirements. * BMI ≥ 30.0 to ≤ 42.0 kg/m2 at screening. * Stable body weight (± 5%) for at least 3 months prior to screening. * hs-CRP ≥ 2 mg/L at screening. * Hypertension or h...

Countries:United States
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Frequently asked questions about VTX3232 Dose A

What is VTX3232 Dose A used for in obesity?

VTX3232 Dose A is an investigational small molecule being studied for the treatment of obesity. It is being evaluated in a Phase 2a clinical trial, both alone and in combination with semaglutide, in adult patients with obesity. The drug is not yet approved and remains in clinical development.

Who makes VTX3232 Dose A?

VTX3232 Dose A is being developed by Ventyx Biosciences, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol VTYX. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational drug for obesity.

What phase is VTX3232 Dose A in?

VTX3232 Dose A is in Phase 2 clinical development. Specifically, it is being studied in a Phase 2a placebo-controlled trial for obesity. The trial has been completed, but the drug remains investigational and has not received FDA approval.

What clinical trials is VTX3232 Dose A in?

VTX3232 Dose A is being studied in clinical trial NCT06771115, a Phase 2a placebo-controlled study of VTX3232 alone or in combination with semaglutide in obesity. This randomized, double-blind trial enrolled 176 participants in the United States and has been completed.

Is VTX3232 Dose A the same as VTX3232?

VTX3232 Dose A is a specific dose of the investigational drug VTX3232. The clinical trial NCT06771115 evaluates VTX3232, including the Dose A regimen, for the treatment of obesity. The drug is being developed by Ventyx Biosciences and is not yet approved.