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AVE1625 B

Phase 2

Obesity | Small molecule | Cardiovascular |Sanofi|Last Updated: Dec 19, 2008

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment345

FDA Designations

No designations recorded

Clinical trial landscape

AVE1625 B · 1 trial · 2 indications

Phase 2 1
NCT00345410Dose-Ranging Study Evaluating AVE1625 in Abdominally Obese Patients With Atherogenic DyslipidemiaObesity
COMPLETED345 Analytics
PHASE2COMPLETED
Dose-Ranging Study Evaluating AVE1625 in Abdominally Obese Patients With Atherogenic Dyslipidemia
ObesityUnlock trial analytics

Study Endpoints

Primary Endpoints

Absolute change from baseline in body weight at 24 weeks

Secondary Endpoints

- relative change from baseline to 24 weeks in plasma HDL-cholesterol and triglycerides levels ; - change from baseline to 24 weeks in waist circumference ; Other criteria: glycemic control parameters.
Safety: physical examination, vital signs, adverse events, ECG, laboratory tests.
Pharmacokinetics: plasma AVE1625 concentrations
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
AVE1625 BDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Abdominal obese patients with · * Waist circumference \> 102 cm in men and \>88 cm in women * Dyslipidemia consisting of : * Triglycerides ≥ 1.50 g/L (i.e 1.69 mmol/L) and ≤ 7.0 g/L(i.e. 7.90 mmol/L)AND/OR * HDL-cholesterol \< 50 mg/dL (i.e. 1.29 mmol/L) in women and \< 4...

Countries:United States
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Frequently asked questions about AVE1625 B

What is AVE1625 B used for?

AVE1625 B is an investigational small molecule being developed for obesity. It was studied in abdominally obese patients with atherogenic dyslipidemia, a condition combining obesity with abnormal blood lipid levels. The drug is in Phase 2 clinical development and is not approved for any use.

What does AVE1625 B target?

AVE1625 B is a small molecule developed by Sanofi. The specific molecular target of AVE1625 B has not been disclosed in available information. It is being investigated for its effects in obesity and dyslipidemia, but the exact mechanism of action is not publicly detailed.

Who makes AVE1625 B?

AVE1625 B is developed by Sanofi, a multinational pharmaceutical company listed on the stock exchange under the ticker SNY. Sanofi is conducting clinical research on this investigational drug for the treatment of obesity and related lipid abnormalities.

What phase is AVE1625 B in?

AVE1625 B is in Phase 2 clinical development. It has completed one Phase 2 trial, and there are no active trials currently listed. The drug remains investigational and has not received regulatory approval for any indication.

What clinical trials is AVE1625 B in?

AVE1625 B has one completed clinical trial registered under NCT00345410, titled "Dose-Ranging Study Evaluating AVE1625 in Abdominally Obese Patients With Atherogenic Dyslipidemia." This Phase 2 study enrolled 345 participants in the United States and was randomized and double-blind.

Is AVE1625 B the same as AVE1625?

AVE1625 B is a designation for the drug also known as AVE1625. The clinical trial NCT00345410 refers to the drug as AVE1625, indicating that AVE1625 B is an alternative name for the same investigational compound developed by Sanofi.