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LABA

Phase 2

Asthma | Small molecule | Respiratory |Roche Holding AG|Last Updated: Nov 2, 2016

Success Probability

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Market & Valuation

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Trial Design

CONTROLLED
Total Trials1
Total Enrollment54

FDA Designations

No designations recorded

Clinical trial landscape

LABA · 1 trial · 1 indication

Phase 2 1
NCT01948401A Study to Measure Serum Periostin, Asthma-Related Biomarkers and Response to Prednisolone in Adult and Adolescent Patients With Severe Oral Corticosteroid-Dependent AsthmaAsthma
COMPLETED54 Analytics
PHASE2COMPLETED
A Study to Measure Serum Periostin, Asthma-Related Biomarkers and Response to Prednisolone in Adult and Adolescent Patients With Severe Oral Corticosteroid-Dependent Asthma
AsthmaUnlock trial analytics

Study Endpoints

Primary Endpoints

Serum periostin levels
up to 95 days

Secondary Endpoints

Asthma quality of life questionnaire for adults and adolescents aged 12 years and older (AQLQ12+)
up to 95 days
IL-13 related biomarker levels
up to 95 days
Lung function: Forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC)
up to 95 days
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP

Treatment Arms

ArmTypeDescription
Controlled asthmaEXPERIMENTAL -
Uncontrolled asthma with additional OCSEXPERIMENTAL -
Uncontrolled asthma without additional OCSEXPERIMENTAL -

Interventions

NameTypeDescription
LABADRUGlong-acting beta-agonist treatment
corticosteroidsDRUGchronic treatment with oral corticosteroids, high dose inhaled corticosteroids
prednisoloneDRUGadditional 0.5 mg/kg orally for 7 days
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Eligibility Criteria

Age Range12 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites11

Inclusion Criteria: * Adult and adolescent patients , \>/=12 to \</=75 years of age at the time of informed consent * Severe asthma (as defined by GINA step 5 classification of asthma severity) after a detailed systematic assessment (the BTS UK Difficult Asthma Network assessment model \[Heaney et ...

Countries:United Kingdom
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Frequently asked questions about LABA

What is LABA used for in asthma?

LABA is a small molecule being investigated for the treatment of asthma. It is currently in Phase 2 clinical development, meaning it is still investigational and has not been approved for use. The drug is being studied in patients with severe asthma who are dependent on oral corticosteroids.

Who is developing LABA?

LABA is being developed by Roche Holding AG, a biopharmaceutical company traded under the ticker RHHBY. The drug is currently in Phase 2 clinical development for the treatment of asthma, and it is still in the investigational stage.

What phase is LABA in?

LABA is in Phase 2 clinical development for asthma. It is an investigational drug, meaning it has not yet been approved by regulatory authorities. The Phase 2 trial for LABA has been completed, and the drug remains under clinical investigation.

What clinical trials is LABA in?

LABA has one completed Phase 2 clinical trial registered under NCT01948401. The study, titled "A Study to Measure Serum Periostin, Asthma-Related Biomarkers and Response to Prednisolone in Adult and Adolescent Patients With Severe Oral Corticosteroid-Dependent Asthma," enrolled 54 participants in the United Kingdom.

Is LABA the same as a long-acting beta agonist?

LABA is the abbreviation for long-acting beta agonist, a class of medications used to treat asthma. In this context, LABA refers to a specific small molecule drug being developed by Roche Holding AG for asthma. It is currently in Phase 2 clinical development and remains investigational.