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GSK5784283

Phase 2

Asthma | Small molecule | Respiratory |GSK plc|Last Updated: May 22, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment307
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06748053A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled AsthmaPHASE2 ACTIVE NOT_RECRUITING 307Feb 10, 2025Sep 9, 2027May 22, 2026133 United States, Bulgaria +7
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Study Endpoints
Primary Endpoints
Part A: Change from baseline in the fraction of exhaled nitric oxide (FeNo)
Baseline (Day 1) and at 2, 4, 8,12, 20 and 26 weeks
Secondary Endpoints
Part A: Change from baseline in blood eosinophil counts
Baseline (Day 1) and at 2, 4, 8,12, 20 and 26 weeks
Part A: Change from baseline in the forced expiratory volume (FEV1) [pre-and post-bronchodilator
Baseline (Day 1) and at 2, 4, 8,12, 20 and 26 weeks
Part A: Change from baseline in the forced vital capacity (FVC) [pre-and post-bronchodilator
Baseline (Day 1) and at 2, 4, 8,12, 20 and 26 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Part A: Dose Finding - GSK5784283EXPERIMENTAL -
Part A: Dose Finding - PlaceboEXPERIMENTAL -
Part B: Extended Dosing - GSK5784283EXPERIMENTAL -
Part B: Extended Dosing - PlaceboEXPERIMENTAL -
Interventions
NameTypeDescription
GSK5784283DRUGGSK5784283 will be administered.
PlaceboDRUGPlacebo will be administered.
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites133

Inclusion Criteria: Participants are eligible to be included in the study only if all of the following criteria apply: * Informed Consent: Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and this p...

Countries:United StatesBulgariaCanadaCzechiaGermanyJapanRomaniaSpainUnited Kingdom
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT06748053primaryCompletionDate: changed
LOWMay 24, 2026NCT06748053studyFirstPostDate: changed