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PG-102

Phase 1

Obesity | Small molecule | Metabolic |Rani Therapeutics Holdings, Inc.|Last Updated: Mar 23, 2025

Target and mechanism

Molecular targetGLP-1/GLP-2 receptor
Target classReceptor
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment60

FDA Designations

No designations recorded

Clinical trial landscape

PG-102 · 1 trial · 1 indication

Phase 1 1
NCT06891287An Early Phase Study of RT-114Obesity
NOT YET_RECRUITING60 Analytics
PHASE1NOT YET_RECRUITING
An Early Phase Study of RT-114
ObesityUnlock trial analytics

Study Design & Arms

Interventions

NameTypeDescription
RT-114 is the RaniPill capsule with PG-102 for the treatment of obesityCOMBINATION_PRODUCTRT-114 is the RaniPill capsule with PG-102 for the treatment of obesity.
PG-102DRUGPG-102 is a drug for the treatment of obesity.
PlaceboOTHERThe placebo is the RaniPill with saline instead of a drug.
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Frequently asked questions about PG-102

What is PG-102 used for?

PG-102 is an investigational small molecule being developed for the treatment of obesity. It is currently in Phase 1 clinical development and has not been approved by the FDA. The drug is being studied in an early phase trial to evaluate its safety and tolerability in patients with obesity.

What does PG-102 target?

PG-102 targets the GLP-1 and GLP-2 receptors. These receptors are involved in metabolic regulation, and their activation is being explored as a therapeutic approach for obesity. The drug is designed to modulate these receptors to potentially influence appetite and energy balance.

Who makes PG-102?

PG-102 is being developed by Rani Therapeutics Holdings, Inc., a biopharmaceutical company traded on the stock exchange under the ticker symbol RANI. The company is conducting clinical research on this drug candidate for the treatment of obesity.

What phase is PG-102 in?

PG-102 is in Phase 1 clinical development. It is an investigational drug that has not yet received regulatory approval. The ongoing Phase 1 trial is designed to assess the drug's safety, tolerability, and pharmacokinetics in participants with obesity.

What clinical trials is PG-102 in?

PG-102 is being evaluated in a Phase 1 clinical trial registered as NCT06891287, titled 'An Early Phase Study of RT-114'. This trial is not yet recruiting and plans to enroll approximately 60 participants with obesity. The study is uncontrolled and does not use randomization or blinding.