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PF-07976016

Phase 2

Obesity | Small molecule | Metabolic |Pfizer, Inc.|Last Updated: Feb 6, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment263
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06717425A Study to Learn About the Study Medicine Called PF-07976016 in Adults With ObesityPHASE2 COMPLETED 263Dec 9, 2024Jan 12, 2026Feb 6, 202638 United States, Canada +1
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Study Endpoints
Primary Endpoints
Percent change from baseline in body weight
Baseline to Week 16
Secondary Endpoints
Number of participants with treatment emergent adverse events
From first dose (Day 1) up to 28-35 days after final dose, a total of approximately 21 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
PF-07976016 Dose 1EXPERIMENTAL -
PF-07976016 Dose 2EXPERIMENTAL -
PF-07976016 Dose 3EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
PF-07976016DRUGTaken once daily
PlaceboDRUGTaken once daily
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Eligibility Criteria
Age Range18 Years — 74 Years
SexALL
Healthy VolunteersNo
Study Sites38

Key Inclusion Criteria: * Male or non-pregnant, non-breastfeeding female, 18 to 74 years of age at Visit 1 * Body Mass Index ≥30.0 kg/m2 at Visit 1, with stable body weight, defined as \<5 kg change in the 12 weeks before Visit 1 * Eligible and willing to receive required background medicine * Will...

Countries:United StatesCanadaPoland
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