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Monlunabant

Phase 1

Obesity | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Nov 18, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment73
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06542536A Research Study Investigating Safety and Concentration in the Blood After One Dose Tablet of the New Medicine Monlunabant in Healthy Weight Japanese and Caucasian MenPHASE1 COMPLETED 73Aug 9, 2024Oct 25, 2024Nov 18, 20251 United States
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Study Endpoints
Primary Endpoints
Number of treatment emergent adverse events (TEAEs) after single dose of oral monlunabant
From dosing (day 1) to end of study visit (day 21)

Number of events

Secondary Endpoints
AUC0-∞,monlunabant, SD; the area under the monlunabant plasma concentration-time curve from time 0 to infinity after single dose of oral monlunabant
From pre-dose (day 1) to end of study visit (day 21)
Cmax, monlunabant, SD; the maximum plasma concentration of monlunabant after single dose of oral monlunabant
From pre-dose (day 1) to end of study visit (day 21)
tmax,monlunabant, SD; the time of maximum observed plasma concentration of monlunabant single dose of oral monlunabant
From pre-dose (day 1) to end of study visit (day 21)
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Monlunabant dose 1EXPERIMENTALDose 1 of monlunabant treatment
Monlunabant dose 2EXPERIMENTALDose 2 of monlunabant treatment
Monlunabant dose 3EXPERIMENTALDose 3 of the monlunabant treatment
Placebo (monlunabant)PLACEBO_COMPARATORPlacebo treatment
Interventions
NameTypeDescription
MonlunabantDRUGOral monlunabant
Placebo (monlunabant)DRUGOral placebo (monlunabant)
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Eligibility Criteria
Age Range18 Years — 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male. * Age 18-55 years (both inclusive) at the time of signing the informed consent. * Considered eligible based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit,...

Countries:United States
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