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Cagrilintide D

Phase 1

Obesity | Small molecule | Metabolic |Novo Nordisk A/S|Last Updated: Jun 26, 2026

Success Probability

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment234

FDA Designations

No designations recorded

Clinical trial landscape

Cagrilintide D · 1 trial · 2 indications

Phase 1 1
NCT07597018A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or ObesityObesity
RECRUITING234 Analytics
PHASE1RECRUITING
A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or Obesity
ObesityUnlock trial analytics

Study Endpoints

Primary Endpoints

AUC,ss: area under the total cagrilintide concentration-time curve at steady state after 5th dosing of cagrilintide s.c.
Day 113 (pre-dose) to Day 120 (post-dose)

Measured in hour nanomoles per litre (h\*nmol/L)

Cmax,ss: maximum concentration of total cagrilintide at steady state after 5th dosing of cagrilintide s.c.
Day 113 (pre-dose) to Day 120 (post-dose)

Measured in nanomoles per litre (nmol/L).

Secondary Endpoints

tmax,ss: time since last dosing to maximum concentration of totala cagrilintide at steady state after 5th dosing of cagrilintide s.c.
Day 113 (pre-dose) to Day 120 (post-dose)
t½,ss: terminal half-life of total cagrilintide at steady state after 5th dosing of cagrilintide s.c.
Day 113 (pre-dose) to Day 162 (post-dose)
Vz/F: the apparent volume of distribution of total cagrilintide during elimination after the 5th dosing of cagrilintide s.c.
Day 113 (pre-dose) to Day 120 (post-dose)
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Cagrilintide B and Placebo Semaglutide IEXPERIMENTALParticipants will receive Cagrilintide B and Placebo semaglutide I subcutaneously once weekly for up to 17 weeks.
Cagrilintide D-Injection site 1EXPERIMENTALParticipants will receive Cagrilintide D subcutaneously once weekly for up to 17 weeks.
Cagrilintide D-Injection site 2EXPERIMENTALParticipants will receive Cagrilintide D subcutaneously once weekly for up to 17 weeks.
Cagrilintide D-Injection site 3EXPERIMENTALParticipants will receive Cagrilintide D subcutaneously once weekly for up to 17 weeks.

Interventions

NameTypeDescription
Cagrilintide DDRUGCagrilintide D will be administered subcutaneously.
Cagrilintide B and placebo semaglutide IDRUGCagrilintide B and placebo semaglutide I will be administered subcutaneously
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Eligibility Criteria

Age Range18 Years to 64 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Aged 18-64 years (both inclusive) at the time of signing informed consent * Body mass index (BMI) between 27.0 and 34.9 kilograms per square metre (kg/m\^2) (both inclusive) at screening. Overweight should be due to excess adipose tissue, as judged by the investigator. * Consi...

Countries:Germany
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Recent Changes (Last 90 Days)

LOWJun 26, 2026NCT07597018Status: NOT_YET_RECRUITING → RECRUITING
LOWJun 26, 2026NCT07597018Status: NOT_YET_RECRUITING → RECRUITING

Frequently asked questions about Cagrilintide D

What is Cagrilintide D used for?

Cagrilintide D is an investigational small molecule being developed for obesity. It is a peptide-based therapy under evaluation in adults with overweight or obesity. The drug is in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who makes Cagrilintide D?

Cagrilintide D is being developed by Novo Nordisk A/S, a biopharmaceutical company traded on the stock exchange under the ticker NVO. The company is conducting clinical research to evaluate the drug's properties in adults with overweight or obesity.

What phase is Cagrilintide D in?

Cagrilintide D is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory agencies. The ongoing Phase 1 trial is recruiting participants to study blood levels of the drug after multiple doses.

What clinical trials is Cagrilintide D in?

Cagrilintide D is being studied in a Phase 1 clinical trial with the identifier NCT07597018. This recruiting study, conducted in Germany, compares blood levels of different versions of cagrilintide after multiple doses in adults with overweight or obesity. The trial has an enrollment target of 234 participants.

Is Cagrilintide D the same as cagrilintide?

Cagrilintide D is a version of cagrilintide being studied by Novo Nordisk. The clinical trial NCT07597018 is designed to compare blood levels of different versions of cagrilintide, including Cagrilintide D, after multiple doses in adults with overweight or obesity.