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Farnesyl Protein Transferase Inhibitor

Phase 1

Neoplasms | Small molecule | Oncology |Merck & Company, Inc.|Last Updated: Feb 18, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment29
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00040547Farnesyl Protein Transferase Inhibitor (FPTI) in Combination With Docetaxel in Advanced Solid Tumors (Study P01964)(COMPLETED)PHASE1 COMPLETED 29Jun 1, 2001Feb 1, 2004Feb 18, 2015 -
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Study Endpoints
Primary Endpoints
Adverse Events
Laboratory Tests
ECG
Secondary Endpoints
Physical Exam
Pharmacokinetics
Tumor Response
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Interventions
NameTypeDescription
Farnesyl Protein Transferase InhibitorDRUG -
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo

Inclusion: * Male or Female * Measurable or evaluable disease * No more than 2 prior chemotherapy regimens. * Age greater than or equal to 18. * Karnofsky Performance Status greater than or equal to 70%. * Meets protocol requirements for specified laboratory values. * No manifestations of a malabso...

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