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ZGN-440 · 1 trial · 1 indication
Measures of the safety and tolerability of ZGN-440 include documentation of adverse events and changes (compared to baseline) in vital signs, physical examination, heart rhythm, and laboratory tests.
| Arm | Type | Description |
|---|---|---|
| ZGN-440 sterile diluent | PLACEBO_COMPARATOR | - |
| ZGN-440 | EXPERIMENTAL | - |
| Name | Type | Description |
|---|---|---|
| ZGN-440 | DRUG | Subjects will receive ZGN-440 twice-weekly over a 4-week treatment period for a total of 8 doses. A range of doses will be evaluated. |
| ZGN-440 sterile diluent | DRUG | Subjects will receive placebo twice-weekly over a 4-week treatment period for a total of 8 doses. A range of doses will be evaluated. |
Inclusion Criteria: * Obese but otherwise healthy females * Non-childbearing potential (surgically sterile, post-menopausal, or receiving implanted or injectable contraceptive for at least 3 months) * BMI ≥ 30 and ≤ 45 kg/m2 * Stable body weight during the past 2 months Exclusion Criteria: * Use ...
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ZGN-440 is an investigational small molecule being developed for the treatment of obesity. It is administered by subcutaneous injection and is intended for use in metabolic conditions. The drug is currently in clinical development and has not been approved by regulatory authorities.
ZGN-440 is being developed by Larimar Therapeutics, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol LRMR. The company is conducting clinical trials to evaluate the drug's safety and efficacy in treating obesity.
ZGN-440 is in Phase 1 clinical development. A Phase 1 trial has been completed, which evaluated the drug in 25 participants with obesity. The drug remains investigational and is not yet approved for commercial use.
ZGN-440 has one completed Phase 1 clinical trial registered under NCT01507077, titled 'ZGN-440 (Beloranib for Subcutaneous Injection) for Treatment of Obesity.' The trial enrolled 25 female participants aged 18 years and older in Australia and was a randomized, double-blind, placebo-controlled study.
Yes, ZGN-440 is also known as beloranib. The clinical trial NCT01507077 refers to the drug as 'ZGN-440 (Beloranib for Subcutaneous Injection),' confirming that ZGN-440 and beloranib are the same investigational compound being studied for obesity.