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LY4174794

Phase 1

Obesity | Small molecule | Metabolic |Eli Lilly and Company|Last Updated: Sep 1, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment108

FDA Designations

No designations recorded

Clinical trial landscape

LY4174794 · 1 trial · 2 indications

Phase 1 1
NCT07654972A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise HealthyObesity
RECRUITING108 Analytics
PHASE1RECRUITING
A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy
ObesityUnlock trial analytics

Study Endpoints

Primary Endpoints

Part A and C: Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Baseline through end of the Follow-up (Week 25)

A summary of TEAEs and SAEs, regardless of causality, will be reported in the Reported Adverse Events module.

Part B: Number of Participants with One or More TEAEs and SAEs Considered by the Investigator to be Related to Study Drug Administration
Baseline through end of the Follow-up (Week 33)

A summary of TEAEs and SAEs, regardless of causality, will be reported in the Reported Adverse Events module.

Secondary Endpoints

Part A and C: Pharmacokinetics (PK): Maximum Observed Drug Concentration (Cmax) of LY4174794
Predose on day 1 through end of the Follow-up Period (Week 25)
Part A and C: PK: Area Under the Concentration Versus Time Curve (AUC) of LY4174794
Predose on day 1 through end of the Follow-up Period (Week 25)
Part B: PK: Maximum Observed Drug Concentration (Cmax) of LY4174794
Predose on day 1 through end of the Follow-up Period (Week 33)
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelSEQUENTIAL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
Part A: LY4174794EXPERIMENTALParticipants will receive LY4174794 administered subcutaneously (SC).
Part B: LY4174794EXPERIMENTALParticipants will receive LY4174794 administered SC.
Part A & B: PlaceboPLACEBO_COMPARATORParticipants will receive placebo administered SC.
Part C: LY4174794EXPERIMENTALParticipants will receive LY4174794 administered intravenously (IV).

Interventions

NameTypeDescription
LY4174794DRUGAdministered SC.
PlaceboDRUGAdministered SC.
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites3

Inclusion Criteria: * Are overtly healthy with no comorbidities related to body mass index (BMI), such as type 2 diabetes mellitus or unstable cardiovascular disease * Are overweight with a BMI of ≥27 kilogram per meter square (kg/m²), or have obesity with a BMI of ≥30 kg/ m² * Have had a self-repo...

Countries:United StatesSingapore
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Recent Changes (Last 90 Days)

LOWSep 1, 2026NCT07654972lastUpdatePostDate: changed
LOWSep 1, 2026NCT07654972lastUpdatePostDate: changed
LOWJul 17, 2026NCT07654972Status: NOT_YET_RECRUITING → RECRUITING
LOWJul 17, 2026NCT07654972Status: NOT_YET_RECRUITING → RECRUITING
LOWJul 17, 2026NCT07654972Status: NOT_YET_RECRUITING → RECRUITING
LOWJun 18, 2026NCT07654972NEW_TRIAL: changed
LOWJun 18, 2026NCT07654972NEW_TRIAL: changed
LOWJun 18, 2026NCT07654972NEW_TRIAL: changed
LOWJun 18, 2026NCT07654972NEW_TRIAL: changed

Frequently asked questions about LY4174794

What is LY4174794 used for?

LY4174794 is an investigational small molecule being developed for obesity. It is being studied in participants with obesity or overweight who are otherwise healthy. The drug is in Phase 1 clinical development and is not yet approved by regulatory authorities.

What does LY4174794 target?

The molecular target of LY4174794 has not been disclosed. It is a small molecule being developed for the treatment of obesity, and its specific mechanism of action is not publicly available at this time.

Who makes LY4174794?

LY4174794 is being developed by Eli Lilly and Company, a pharmaceutical company listed on the New York Stock Exchange under the ticker symbol LLY.

What phase is LY4174794 in?

LY4174794 is in Phase 1 clinical development. It is an investigational drug being studied for obesity and has not been approved by the FDA or any other regulatory agency.

What clinical trials is LY4174794 in?

LY4174794 is being studied in a Phase 1 clinical trial with the identifier NCT07654972. This trial is recruiting participants with obesity or overweight who are otherwise healthy, with an enrollment of 108 participants across the United States and Singapore.

Is LY4174794 the same as any other drug?

No alternative names for LY4174794 have been disclosed. It is a unique investigational compound being developed by Eli Lilly and Company for the treatment of obesity.