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Atezolizumab · 1 trial · 1 indication
PFS was defined as the time from randomization to the date of first documented PD as determined by the IRF according to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1) or death, whichever occurs first. PD was defined as appearance of a new lesion(s), unequivocal progression in non-target lesion(s) or at least a 20% increase in the sum of diameters (SOD) of target lesions, taking as reference the smallest sum on the study including baseline (nadir). In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 millimetres (mm).
OS was defined as the time from randomization to the date of death from any cause.
| Arm | Type | Description |
|---|---|---|
| Arm A: Atezolizumab+Lurbinectedin | EXPERIMENTAL | Induction phase: participants will receive standard of care atezolizumab on Day 1 of each 21-day cycle in combination with carboplatin on Day 1 and etoposide on Days 1, 2, and 3 of each 21-day cycle for 4 cycles. Maintenance phase: participants will receive atezolizumab on Day 1 of each 21-day cycle in combination with lurbinectedin on Day 1 of each 21-day cycle. |
| Arm B: Atezolizumab | ACTIVE_COMPARATOR | Induction phase: participants will receive standard of care atezolizumab on Day 1 of each 21-day cycle in combination with carboplatin on Day 1 and etoposide on Days 1, 2, and 3 of each 21-day cycle for 4 cycles. Maintenance phase: participants will receive atezolizumab on Day 1 of each 21-day cycle. |
| Name | Type | Description |
|---|---|---|
| Atezolizumab | DRUG | Atezolizumab will be administered intravenously at a fixed dose of 1200 mg on Day 1 of each 21-day cycle for 4 cycles in the induction phase. Atezolizumab will be administered intravenously at a fixed dose of 1200 mg on Day 1 of each 21-day cycle in the maintenance phase. |
| Lurbinectedin | DRUG | Lurbinectedin 3.2 mg/m² will be administered intravenously on Day 1 of each 21-day cycle in the maintenance phase. |
| Carboplatin | DRUG | Carboplatin will be administered according to the standard of care treatment for 4 cycles in the induction phase. |
| Etoposide | DRUG | Etoposide will be administered according to the standard of care treatment for 4 cycles in the induction phase. |
Inclusion Criteria for the Induction Phase: * ECOG PS of 0 or 1 * No prior systemic therapy for ES-SCLC * Treatment-free for at least 6 months since last chemo/radiotherapy, among those treated (with curative intent) with prior chemo/radiotherapy for limited-stage SCLC * Histologically or cytologic...
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Atezolizumab is an investigational drug being studied for the treatment of extensive-stage Small-Cell Lung Cancer. It is currently in a Phase 3 clinical trial as a maintenance therapy, given in combination with lurbinectedin, compared with atezolizumab alone, in participants with this condition.
Atezolizumab targets CD274, also known as PD-L1, and acts as an inhibitor of this target. By inhibiting CD274, the drug is designed to interfere with the interaction between PD-L1 and its receptors, which is a mechanism relevant to its investigation in oncology.
Atezolizumab is being developed by Jazz Pharmaceuticals plc, a company traded on the stock exchange under the ticker JAZZ. The company is conducting clinical research on this drug for the treatment of Small-Cell Lung Cancer.
Atezolizumab is currently in Phase 3 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still undergoing clinical trials to evaluate its safety and efficacy for the treatment of Small-Cell Lung Cancer.
Atezolizumab is being studied in a Phase 3 clinical trial registered as NCT05091567. This open-label, active-controlled trial is investigating maintenance treatment with lurbinectedin combined with atezolizumab versus atezolizumab alone in participants with extensive-stage Small-Cell Lung Cancer. The trial has an enrollment of 660 participants.
No, Atezolizumab is not the same as lurbinectedin. Atezolizumab is the investigational drug being studied, while lurbinectedin is a separate drug used in combination with atezolizumab in the clinical trial. The trial compares the combination of lurbinectedin plus atezolizumab against atezolizumab alone.