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Durvalumab

Phase 2

Ovarian Cancer | Small molecule | Oncology |BioAtla, Inc.|Last Updated: Jul 21, 2026

Target and mechanism

Molecular targetCD274
Target classInhibitor
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

CONTROLLEDDMC
Total Trials1
Total Enrollment60

FDA Designations

No designations recorded

Clinical trial landscape

Durvalumab · 1 trial · 1 indication

Phase 2 1
NCT04918186Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian CancerOvarian Cancer
RECRUITING60 Analytics
PHASE2RECRUITING
Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer
Ovarian CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

To efficiently identify based on objective response rate (ORR), by investigator assessment using RECIST 1.1, promising immunotherapy combinations for the treatment of high grade serous ovarian cancer for later validation in randomized trials
36 months

Secondary Endpoints

Evaluate ORR by investigator assessment using RECIST 1.1
36 months
Determine progression-free survival of immunotherapy regimens (RECIST 1.1 and iRECIST)
36 months
Determine overall-survival of immunotherapy regimens (RECIST 1.1 and iRECIST)
36 months
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Durvalumab + BA3011 (Arm Closed)EXPERIMENTAL -
Durvalumab + BA3021 (Arm Closed)EXPERIMENTAL -
ENB-003 + ToripalimabEXPERIMENTAL -

Interventions

NameTypeDescription
DurvalumabDRUG1500mg IV, 60 min day 1 every 4 weeks
BA3011DRUGIV
BA3021DRUGIV
ENB003DRUGIV
ToripalimabDRUGIV
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Eligibility Criteria

Age Range18 Years to N/A
SexFEMALE
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * This study will enroll women with platinum resistant high grade serous ovarian cancer. * This study is open to minorities as appropriate but is not designed to measure differences in intervention effects. * All patients must be registered for screening prior to study enrollmen...

Countries:United StatesCanada
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Competitive Landscape -Ovarian Cancer 176 trials

Top 20 of 59 competitors

CompanyTickerTrialsLead PhaseDrugs
Merck & Co., Inc.MRK5PHASE3Pembrolizumab, Paclitaxel, Bevacizumab, Docetaxel
AstraZeneca PLCAZN19PHASE3Olaparib
GSK plc Sponsored ADRGSK4PHASE3Niraparib
Eli Lilly and CompanyLLY8PHASE3Sofetabart Mipitecan, Paclitaxel, Topotecan, Gemcitabine, Pegylated liposomal doxorubicin
AbbVie, Inc.ABBV13PHASE3Mirvetuximab soravtansine plus Bevacizumab, Bevacizumab
Bristol-Myers Squibb CompanyBMY4PHASE3Rucaparib, Nivolumab
Genmab A/S Sponsored ADRGMAB5PHASE3Rina-S, Paclitaxel, Topotecan, Pegylated liposomal doxorubicin, Gemcitabine
Pfizer Inc.PFE4PHASE3Avelumab, Lorlatanib, Talazoparib, Pemetrexed, Axitinib
Corcept Therapeutics Incorporated.CORT2PHASE3Nab-paclitaxel/m^2, Relacorilant once daily
Verastem, Inc.VSTM4PHASE3avutometinib, Defactinib, Pegylated liposomal doxorubicin, Paclitaxel, Letrozole
Zentalis Pharmaceuticals, Inc.ZNTL3PHASE3Azenosertib
Imunon, Inc.IMNN3PHASE3IMNN-001, Paclitaxel, Carboplatin, Olaparib, Niraparib
Incyte CorporationINCY2PHASE3INCB123667
Genelux Corp.GNLX1PHASE3olvimulogene nanivacirepvec, Platinum chemotherapy: carboplatin or cisplatin, Non-platinum chemotherapy: Physician's Choice of gemcitabine, taxane or pegylated liposomal doxorubicin, Bevacizumab
Regeneron Pharmaceuticals, Inc.REGN4PHASE2Ubamatamab, Bevacizumab, Cemiplimab, Fianlimab, PLD
Novartis AG Sponsored ADRNVS4PHASE2Dabrafenib, Trametinib
BeOne Medicines Ltd. Sponsored ADRONC2PHASE3Pamiparib
IQVIA Holdings IncIQV1PHASE3Oregovomab, Paclitaxel, Carboplatin
Xencor, Inc.XNCR3PHASE2vudalimab
Exelixis, Inc.EXEL2PHASE2Cabozantinib
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Recent Changes (Last 90 Days)

LOWJul 21, 2026NCT04918186lastUpdatePostDate: changed
MEDIUMJul 14, 2026NCT04918186primaryCompletionDate: changed
MEDIUMJul 14, 2026NCT04918186primaryCompletionDate: changed

Frequently asked questions about Durvalumab

What is Durvalumab used for in ovarian cancer?

Durvalumab is being studied for the treatment of platinum resistant high grade serous ovarian cancer. It is an investigational immunotherapy being evaluated in a Phase 2 clinical trial for this indication. The drug is administered to adult female patients as part of a controlled study.

What does Durvalumab target?

Durvalumab is a monoclonal antibody, indicated by its -mab suffix. It is designed to work within the immune system to fight cancer. The specific molecular target of Durvalumab is not disclosed in the available information, but as an antibody, it is intended to modulate immune responses against tumor cells.

Who is developing Durvalumab?

Durvalumab is being developed by BioAtla, Inc., a biopharmaceutical company. The company is listed on the stock exchange under the ticker symbol BCAB. BioAtla is conducting clinical research to evaluate the safety and efficacy of Durvalumab in patients with ovarian cancer.

What phase is Durvalumab in?

Durvalumab is currently in Phase 2 clinical development. It is an investigational drug, meaning it has not yet been approved by regulatory authorities. The ongoing Phase 2 trial is recruiting patients to further assess its potential as a treatment for platinum resistant high grade serous ovarian cancer.

What clinical trials is Durvalumab in?

Durvalumab is being evaluated in a single Phase 2 clinical trial with the identifier NCT04918186. This study is titled "Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer" and is currently recruiting participants. The trial is being conducted in the United States and Canada, with a planned enrollment of 60 female patients aged 18 years and older.

Is Durvalumab the same as any other drug?

Durvalumab is a distinct drug candidate developed by BioAtla, Inc. It is not known to be the same as any other marketed medication. As a monoclonal antibody, it is part of a class of immunotherapies, but its specific identity and mechanism are unique to this investigational product.