Recent Updates
Recently added Catalysts

Ecabet

Phase 2

Dry Eye Syndromes | Small molecule | Ophthalmology |Bausch + Lomb Corporation|Last Updated: Mar 15, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment162
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00370747Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye SyndromePHASE2 COMPLETED 162Sep 1, 2006Jun 1, 2007Mar 15, 20131 United States
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Ocular signs and Symptoms
90 days

ocular signs, including corneal and conjunctival staining, tear film breakup time and blink rate, and ocular symptoms, including burning or stinging, itchiness or scratchiness, grittiness or sandiness, foreign body sensation, haziness or blurriness, photophobia, photopsia, and eye discomfort

Secondary Endpoints
Ocular Surface Disease Index (OSDI)
90 days
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
EcabetEXPERIMENTALOphthalmic solution in the Study eye four times daily for 90 days.
PlaceboPLACEBO_COMPARATOROphthalmic solution in the Study eye four times daily for 90 days.
Interventions
NameTypeDescription
EcabetDRUGophthalmic solution 2.83%
PlaceboDRUG -
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Male/female at least 18 years of age * Agree to avoid disallowed medications * Have a diagnosis of dry eye Exclusion Criteria: * Have chronic systemic inflammation * Have active seasonal ocular allergies

Countries:United States
Unlock Eligibility Criteria
Competitive Landscape -Myelodysplastic Syndromes 76 trials
Unlock Competitive Intelligence