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argenx SE

ARGXFDA catalysts, PDUFA dates & pipeline intelligence
$960.04
▼ -21.29 · -2.17%

Financials

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52W LOW $661.8552W HIGH $1,072.75
Volume
225.89 K
Value Traded
218.31 M
Short % Float
2.25%
Days to Cover
3.4
-0.23%Week
+13.44%1 Month
-2.81%3 Month
+23.68%6 Month
+197.06%5 Year
+4,405.36%All Time

Cash Data

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Key Stats

Market Cap
60.37 B
EPS (TTM)
21.10
P/E Ratio
45.51
Ent. Value
45.93 B
Total Shares
62.89 M
Float Shares
62.76 M
Insiders
0.19%
Institutions
45.81%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
Phase 3 topline data readout
empasiprubart
multifocal motor neuropathy (MMN)
Phase 3BiologicsNervous System
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

ARGX Catalyst Timeline

Dated clinical, regulatory and corporate events for argenx SE

Catalyst Timeline

Dated clinical, regulatory & corporate events for argenx SE

782Total events
22Upcoming
253Tier-1 (high impact)
2015 to 2027Coverage

Upcoming catalysts 2

T1Topline Readout
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Empasiprubart
T1Topline Readout
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EfgartigimodApproved

Event history 50

◆Late-BreakerEfgartigimodApprovedPresentation
ALKIVIA data featured in late-breaking oral presentation at ACR Convergence 2026
autoimmune myositissource ↗
▲AcquisitionCorporate
argenx signs definitive agreement to acquire Unnatural Products for up to ~$1.15B
▲AcquiredCorporate
argenx to acquire Unnatural Products for up to ~$1.15B ($550M upfront plus CVRs)
▲Corporate ApprovalCorporate
Boards of directors of argenx and UNP approve the acquisition
▲Secondary Endpoint DataEfgartigimodApprovedClinical Data
IMNM subtype showed 14.8-point greater TIS improvement vs placebo at Week 52
immune-mediated necrotizing myopathy (IMNM)source ↗
●Subgroup AnalysisEfgartigimodApprovedClinical Data
DM subgroup showed 14.5-point greater TIS improvement vs placebo at Week 52, not statistically significant (p=0.1093)
dermatomyositis (DM)source ↗
●Safety Data UpdateEfgartigimodApprovedClinical Data
Efgartigimod generally well tolerated in ALKIVIA, consistent with known safety profile
autoimmune myositissource ↗
▲Primary Endpoint MetEfgartigimodApprovedClinical Data
ALKIVIA met primary endpoint in combined IMNM and DM population
autoimmune myositis (combined IMNM and DM)source ↗
●Quarterly UpdateCorporate
argenx reports third quarter 2026 financial results and business update
▲Primary Endpoint MetFB102Clinical Data
FB102 met primary endpoint of change in Vh:Cd ratio at day 78 (p=0.0176)
celiac diseasesource ↗
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Past FDA Catalysts and PDUFA Decisions

How ARGX actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-11-11VYVGART Hytrulo (efgartigimod alfa and hyaluronidase-qvfc; efgartigimod PH20 SC) Phase 3 data presentation Phase 3
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

Pipeline Score
Pipeline Value
Commercial Value
Valuation Signal
9
Drugs Scored
rNPV / MCap
Top Drug
Top 13%
Large Pharma
(rank 90 of 687)
Percentile Rank
Commercial products (revenue basis: trailing 4 quarters of total revenue (20-F and 6-K), to Jun 2026; product lines: last four quarters to Jun 2026 (20-F and 6-K))
ProductRevenuePrior periodChange
VYVGART
Showing 47 of 51 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
Empasiprubart BiologicsNCT06920004Chronic Inflammatory Demyelinating PolyneuropathyPhase 3 RECRUITING 378Sep 1, 2030
Empasiprubart BiologicsNCT06742190Multifocal Motor Neuropathy (MMN)Phase 3 ACTIVE NOT_RECRUITING 214Dec 1, 2029
Empasiprubart BiologicsNCT06284954DermatomyositisPhase 2 ACTIVE NOT_RECRUITING 3Nov 1, 2026
ARGX-117 BiologicsNCT05907096Delayed Graft FunctionPhase 2 ACTIVE NOT_RECRUITING 103May 1, 2030
ARGX-117 BiologicsNCT05405361Multifocal Motor NeuropathyPhase 2 ACTIVE NOT_RECRUITING 105Sep 30, 2029
Empasiprubart BiologicsNCT07821762Guillain-Barré Syndrome (GBS)Phase 2 NOT YET_RECRUITING 63Mar 1, 2029
Empasiprubart BiologicsNCT07673627AChR-Ab Seropositive Generalized Myasthenia GravisPhase 2 RECRUITING 40Apr 1, 2028
ARGX-121 BiologicsNCT07773727Immunoglobulin A Nephropathy (IgAN)Phase 2 RECRUITING 120Feb 18, 2030
Efgartigimod BiologicsNCT07194850Immune Thrombocytopenia (ITP)Phase 2/3 RECRUITING 24Oct 1, 2030
Efgartigimod PH20 SC BiologicsNCT04812925Primary Immune ThrombocytopeniaPhase 3 ACTIVE NOT_RECRUITING 380Oct 1, 2027
Efgartigimod PH20 SC BiologicsNCT06684847Primary Sjogrens DiseasePhase 3 ACTIVE NOT_RECRUITING 631Jul 1, 2028
Efgartigimod PH20 SC BiologicsNCT07570316Graves DiseasePhase 3 RECRUITING 460May 1, 2030
Efgartigimod PH20 SC BiologicsNCT05979441MyositisPhase 3 ENROLLING BY_INVITATION 240Sep 1, 2028
Efgartigimod BiologicsMarketedNCT06298552Generalized Myasthenia GravisApproved ACTIVE NOT_RECRUITING 215Jun 1, 2028
Efgartigimod PH20 SC Small MoleculesNCT06558279Myasthenia Gravis, OcularPhase 3 ACTIVE NOT_RECRUITING 141Dec 1, 2027
Efgartigimod Small MoleculesMarketedNCT06765161Myasthaenia GravisApproved RECRUITING 30Jan 6, 2027
Efgartigimod PH20 SC BiologicsNCT07583641Autoimmune Encephalitis (AE)Phase 2 NOT YET_RECRUITING 170Jul 30, 2030
Efgartigimod PH20 SC BiologicsNCT07760818Sjogrens DiseasePhase 2 NOT YET_RECRUITING 75Jul 28, 2029
Efgartigimod PH20 SC Small MoleculesNCT06503731Antibody-mediated RejectionPhase 2 ACTIVE NOT_RECRUITING 33Nov 1, 2027
Efgartigimod PH20 SC Small MoleculesNCT06655155Systemic Sclerosis (SSc)Phase 2 ACTIVE NOT_RECRUITING 87Oct 1, 2027
Efgartigimod BiologicsMarketedNCT07284420AChR-Ab Seropositive Generalized Myasthenia GravisApproved RECRUITING 70Mar 7, 2028
Cusatuzumab BiologicsNCT04150887Leukemia, Myeloid, AcutePhase 2 ACTIVE NOT_RECRUITING 170May 15, 2027
ARGX-119 BiologicsNCT07287982Spinal Muscular Atrophy (SMA)Phase 2 RECRUITING 60May 28, 2029
ARGX-119 BiologicsNCT06436742Congenital Myasthenic SyndromePhase 1 ACTIVE NOT_RECRUITING 15Jan 24, 2028
ARGX-124 BiologicsNCT07377396UndisclosedPhase 1 RECRUITING 104Dec 31, 2026
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PTRS, rNPV, enrollment velocity, trial design quality and ML risk signals for every asset above.
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Clinical Trial Results

Readouts, endpoints and source filings for every ARGX program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
efgartigimod
BreakthroughPriority
autoimmune myositisPhase 32026-11-07primary result: 15.4-point improvement in Total Improvement Score at Week 52 compared to placebo; improvement IMNM: 14.8-point greater improvement in mean TIS versus placebo at Week 52; TIS 40: 22.0 percentage-point difference in achieving TIS ≥ 40 at Week 52; MMT 8: 5.4 points greater improvement in Manual Muscle Testing-8 versus placebo; CK reduction: 43.5 percentage-point greater reduction in CK levels from baseline versus placebo; CK grade: 0.9-grade greater reduction in CK gradeRead Moreargenx Presents Phase 3 ALKIVIA Data at ACR Convergence 2026 Showing Rapid and Sustained Improvement with Efgartigimod in Autoimmune MyositisRead More
Scroll for more · summaries link to the source press release
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Inside Trades

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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
Avoro Capital Advisors LLC 8.3 % (15.3 %) 927.77 M 1.00 M
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Ownership Trends

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Insider and institutional ownership, quarter by quarter.

ARGX Short Interest

Shares sold short, counted twice a month.

2.25%
Short % of Float
of tradable shares sold short
1.4M
Shares Sold Short
+4.3% vs prior count
3.4 Moderate
Days to Cover
trading days of normal volume to buy every short share back
413.0K
Avg Daily Volume
the average used for days to cover
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Two years of days to cover and shares sold short, with every count and its change.
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Options Data

Option Volume

Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg

Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2026-11-20
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Real-Time Option Chain

CallsStrikePuts
LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

CallsPutsLog scale
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Competitive positioning

How ARGX ranks across every disease it competes in

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See how ARGX ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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ARGX News

ARGX
Nov 9, 2026
ARGXGeneral

argenx to Acquire Unnatural Products, Inc., Adding Peptide Discovery Engine to Broaden Immunology Capabilities

argenx announced its acquisition of Unnatural Products, Inc. for up to $1.15 billion. This deal enhances argenx's capabilities in immunology, particularly in developing oral and long-acting medicines. UNP will maintain its operations in Santa Cruz, California, preserving its culture and team. The acquisition is expected to close by year-end, pending customary conditions.

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ARGX
Nov 9, 2026
ARGXGeneral

Unnatural Products to be Acquired by argenx for up to $1.15 Billion to Advance Next-Generation Medicines

argenx announced its acquisition of Unnatural Products, Inc. for up to $1.15 billion, including $550 million upfront. This acquisition aims to enhance argenx's capabilities in developing oral macrocyclic peptides. UNP will continue operations in Santa Cruz, contributing to argenx's innovation in immunology. The deal is expected to close by year-end, pending customary conditions.

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ARGX
Nov 7, 2026
ARGXPhases

argenx Presents Phase 3 ALKIVIA Data at ACR Convergence 2026 Showing Rapid and Sustained Improvement with Efgartigimod in Autoimmune Myositis

argenx presented data from the Phase 3 ALKIVIA study at ACR Convergence 2026, showing that efgartigimod significantly improved outcomes in patients with autoimmune myositis. The study met its primary endpoint, demonstrating a 15.4-point improvement in the Total Improvement Score at Week 52 compared to placebo. Efgartigimod was well tolerated, supporting its potential as the first targeted treatment for immune-mediated necrotizing myopathy.

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ARGX
Nov 3, 2026
ARGXConferences/Events

argenx to Present at Upcoming Investor Conferences

argenx announced its participation in two upcoming investor conferences in November. The management team will engage in fireside chats at the Guggenheim 3rd Annual Healthcare Innovation Conference and the Jefferies London Global Healthcare Conference. Live webcasts of these presentations will be available on the company's website.

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ARGX
Oct 22, 2026
ARGXGeneral

argenx Reports Third Quarter 2026 Financial Results and Provides Business Update

argenx reported strong third quarter 2026 results with $1.7 billion in net sales, a 54% increase year-over-year. The company is on track to submit a supplemental biologics license application for VYVGART in ocular myasthenia gravis by year-end. Upcoming Phase 3 data for empasiprubart in multifocal motor neuropathy is expected in December 2026.

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ARGX
Oct 19, 2026
ARGXPhases

argenx to Present Phase 3 ALKIVIA Results in Autoimmune Myositis as a Late-Breaking Oral Presentation at ACR Convergence 2026

argenx announced positive results from the Phase 3 ALKIVIA study, demonstrating that efgartigimod significantly improves symptoms in patients with autoimmune myositis, particularly IMNM and DM. The results will be presented as a late-breaking oral presentation at ACR Convergence 2026. The study achieved its primary endpoint, showing a substantial improvement in the Total Improvement Score compared to placebo.

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ARGX
Oct 15, 2026
ARGXConferences/Events

argenx to Report Third Quarter 2026 Financial Results and Business Update on October 22, 2026

argenx has announced a conference call scheduled for October 22, 2026, to discuss its third quarter financial results and provide a business update. The call will be accessible via a live webcast and phone dial-in options. The company emphasizes its commitment to immunology innovation and the development of treatments for underserved diseases.

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ARGX
Oct 8, 2026
ARGXPhases
▼ -11.8%on this news

argenx Announces Positive Topline Results from Phase 2 Study of FB102 in Celiac Disease

argenx announced positive topline results from a Phase 2 study of FB102, a CD122 inhibitor, in adults with celiac disease. The study met its primary endpoint, showing a significant change in the villus height-to-crypt depth ratio compared to placebo. The safety profile was consistent with prior studies, and argenx plans to advance FB102 into Phase 3 development.

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ARGX
Oct 8, 2026
ARGXPhases
▼ -11.8%on this news

argenx Provides Update on Phase 3 UNITY Study of Efgartigimod SC in Sjögren's Disease

argenx SE has announced the discontinuation of its Phase 3 UNITY study of efgartigimod SC in Sjögren's disease, following a recommendation from an Independent Data Monitoring Committee. The study was halted for futility after an interim analysis indicated it could not meet its primary endpoint. Despite consistent safety profiles, this outcome is a setback for patients awaiting effective treatments.

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ARGX
Sep 29, 2026
ARGXConferences/Events

argenx Presents New Data at AANEM and MGFA Scientific Session Showcasing Earlier and Sustained Treatment in MG and CIDP with VYVGART and Progress Across its Neuromuscular Pipeline

argenx presented new data at the AANEM and MGFA sessions, highlighting VYVGART's effectiveness in treating myasthenia gravis (MG) and chronic inflammatory demyelinating polyneuropathy (CIDP). The data showed significant improvements in ocular MG and sustained efficacy in patients without detectable anti-AChR antibodies. Additionally, real-world evidence indicated that earlier treatment with VYVGART leads to better patient outcomes.

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ARGX
Sep 17, 2026
ARGXGeneral

argenx announces results of Extraordinary General Meeting of Shareholders and appointment of Thomas M. Brakel and Khurem Farooq as Non-Executive Directors

argenx SE announced the results of its Extraordinary General Meeting, appointing Thomas M. Brakel and Khurem Farooq as non-executive directors. The company emphasizes its commitment to scientific innovation and enhancing shareholder value. The appointments are seen as a strategic move to strengthen the Board as argenx aims for long-term growth and impact in immunology.

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ARGX
Aug 17, 2026
ARGXPhases
▲ +16%on this news

argenx Announces Positive Topline Results from Phase 3 ALKIVIA Trial of Efgartigimod in Autoimmune Myositis

argenx announced positive topline results from the Phase 3 ALKIVIA trial of efgartigimod in patients with autoimmune myositis. The study met its primary endpoint, demonstrating a significant improvement in the Total Improvement Score at 52 weeks. Efgartigimod showed consistent benefits across both IMNM and DM subtypes, marking a significant advancement in treatment options for these patients.

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ARGX
Aug 3, 2026
ARGXGeneral

argenx announces Extraordinary General Meeting of Shareholders on September 17, 2026

argenx SE has announced an Extraordinary General Meeting of Shareholders scheduled for September 17, 2026, in Amsterdam. The meeting will focus on the proposed appointments of two new non-executive directors to the Board. Shareholders are encouraged to attend in person or vote by proxy, with detailed information available on the company's website.

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ARGX
Jul 27, 2026
ARGXGeneral

argenx to Acquire Forte Biosciences, Inc., Adding First-in-Class Anti-CD122 Antibody, FB102, to Its Immunology Pipeline

argenx has announced its acquisition of Forte Biosciences for $77 per share, totaling approximately $2.2 billion. This strategic move aims to enhance argenx's immunology portfolio by adding FB102, a first-in-class anti-CD122 antibody. The acquisition reflects argenx's commitment to expanding its innovative treatment options in immunology.

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ARGX
Jul 23, 2026
ARGXGeneral
▲ +8.6%on this newsshared move

argenx Reports Half Year 2026 Financial Results and Provides Second Quarter Business Update

argenx reported strong financial results for the second quarter of 2026, with $1.5 billion in global product net sales, marking a 60% increase year-over-year. The company successfully launched expanded indications for VYVGART and VYVGART Hytrulo, now covering all gMG serotypes. Key registrational study readouts are expected in the second half of 2026, supporting the company's growth strategy.

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ARGX
Jul 16, 2026
ARGXConferences/Events

argenx to Report Half Year 2026 Financial Results and Second Quarter Business Update on July 23, 2026

argenx has announced a conference call scheduled for July 23, 2026, to discuss its half-year financial results and provide a business update for the second quarter. The call will be accessible via a webcast and various international dial-in numbers. The company focuses on developing treatments for severe autoimmune diseases.

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ARGX
Jun 23, 2026
ARGXConferences/Events
▼ -5.6%on this news

argenx to Host Autoimmune Myositis R&D Webinar

argenx is hosting a webinar on June 23, 2026, focusing on autoimmune myositis and their advancements in FcRn leadership. The event will feature key opinion leaders from prestigious institutions discussing the latest research and developments. A live webcast will be available, along with supporting materials on their website.

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ARGX
Jun 3, 2026
ARGXConferences/Events

argenx Presents New Efgartigimod Data Showing Long-Term Sustained Patient Benefit in Myositis and Sjogren’s Disease at EULAR 2026

Argenx presented new data on efgartigimod at EULAR 2026, demonstrating its long-term benefits in myositis and Sjogren's disease. The ALKIVIA+ study showed sustained improvements in myositis patients, while the RHO+ study confirmed maintenance of response in Sjogren's disease. Efgartigimod's safety profile remained consistent across various autoimmune conditions.

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ARGX
May 28, 2026
ARGXConferences/Events

argenx to Host Myositis R&D Webinar on June 23, 2026

argenx announced a webinar titled 'R&D Spotlight: Advancing FcRn Leadership into Autoimmune Myositis' scheduled for June 23, 2026. This event is part of a mini-series aimed at showcasing the company's research and development strategy. The webinar will feature discussions on myositis, including disease biology and the ALKIVIA clinical program for efgartigimod.

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About argenx SE

1,863 employees argenx.com
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