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R&D Expenses
Operating CF
Total Assets
Total Liabilities
Equity
Shares Out.
D/E Ratio
Dilution Watch
Financials
52W LOW $22.2452W HIGH $46.00
Volume
835.68 K
Value Traded
34.92 M
Short % Float
12.97%
+1.79%Week
-5.44%1 Month
-21.55%3 Month
-4.04%6 Month
-50.85%5 Year
-2.97%All Time
Cash Data
- Monthly Burn
- Burn Trend
- Dilution Risk
- SEC Filing
Key Stats
Market Cap
1.90 B
EPS (TTM)
-6.89
P/E Ratio
-
Ent. Value
934.29 M
Total Shares
59.71 M
Float Shares
58.25 M
Insiders
2.42%
Institutions
113.55%
Upcoming Catalysts
FDA decisions, readouts and PDUFA dates · scored by probability of approval
PoA blends historical approval base rates, trial design score and FDA review track record.
AGIO Catalyst Timeline
Dated clinical, regulatory and corporate events for Agios Pharmaceuticals, Inc.
Catalyst Timeline
Dated clinical, regulatory & corporate events for Agios Pharmaceuticals, Inc.
1073Total events
9Upcoming
208Tier-1 (high impact)
2014 to 2028Coverage
Upcoming catalysts 2
Event history 50
▲Oral PresentationMitapivatApprovedPresentation
Presentation of RISE UP Phase 3 results at EHA 2026 Plenary Session
sickle cell diseasesource ↗
◆Poster PresentationMitapivatApprovedPresentation
Poster on metabolic profile of Diamond-Blackfan anemia syndrome erythroid progenitors
Diamond-Blackfan anemia syndromesource ↗
◆Full ResultsMitapivatApprovedClinical Data
Detailed efficacy and safety data from RISE UP Phase 3 trial presented at EHA 2026
sickle cell diseasesource ↗
◆Long Term DataMitapivatApprovedClinical Data
Long-term data from ENERGIZE open-label extension showing durability up to 127 weeks
non-transfusion-dependent alpha- or beta-thalassemiasource ↗
◆Poster PresentationMitapivatApprovedPresentation
Poster on subgroup analysis of ENERGIZE in patients with baseline hemoglobin ≥9.5 g/dL
non-transfusion-dependent alpha- or beta-thalassemiasource ↗
◆Subgroup AnalysisMitapivatApprovedClinical Data
Subgroup analysis of ENERGIZE in patients with baseline hemoglobin ≥9.5 g/dL
non-transfusion-dependent alpha- or beta-thalassemiasource ↗
◆Oral PresentationMitapivatApprovedPresentation
Oral presentation of SATISFY Phase 2 trial results at EHA 2026
hereditary spherocytosis, hereditary xerocytosis, congenital dyserythropoietic anemia type IIsource ↗
◆Long Term DataMitapivatApprovedClinical Data
56-week follow-up results from SATISFY study on iron burden and spleen size
hereditary spherocytosis, hereditary xerocytosis, congenital dyserythropoietic anemia type IIsource ↗
▲Partnership / LicensecevidoplenibCorporate
Agios enters exclusive global license agreement with Oscotec for cevidoplenib
immune thrombocytopeniasource ↗
●Quarterly UpdateCorporate
Agios hosts investor conference call and webcast to discuss license agreement
◆PublicationMitapivatApprovedPresentation
Publication on ENERGIZEKIDS trial in pediatric patients with non-transfusion-dependent thalassemia
non-transfusion-dependent alpha- or beta-thalassemiasource ↗
▼Program DiscontinuationTebapivatDiscontinuedCorporate
Agios will not advance tebapivat in LR-MDS after Phase 2b trial missed predefined threshold
lower-risk myelodysplastic syndromes (LR-MDS)source ↗
▲EU ApprovalMitapivatApprovedEx-US Regulatory
PYRUKYND (mitapivat) authorized in the European Union for adults with thalassemia
talasemiasource ↗
▲EU ApprovalMitapivatApprovedEx-US Regulatory
PYRUKYND (mitapivat) approved in EU for adults with thalassaemia
thalassaemiasource ↗
▲EU ApprovalMitapivatApprovedEx-US Regulatory
European Commission grants marketing authorization for PYRUKYND in adults with thalassemia
thalassemiasource ↗
●sNDA SubmissionMitapivatApprovedRegulatory Filing
Agios submits sNDA to FDA for accelerated approval of mitapivat in sickle cell disease
sickle cell diseasesource ↗
●sNDA SubmissionMitapivatApprovedRegulatory Filing
sNDA submission to FDA for accelerated approval of mitapivat in sickle cell disease
sickle cell diseasesource ↗
▲Accelerated Approval PathwayMitapivatApprovedDesignation
FDA agreed to accelerated approval pathway for mitapivat in sickle cell disease
sickle cell diseasesource ↗
●Timing GuidanceMitapivatApprovedPresentation
Plan to submit sNDA for mitapivat in sickle cell disease in Q2 2026
sickle cell diseasesource ↗
▲Pre BLA MeetingMitapivatApprovedFDA Meeting
Pre-sNDA meeting with FDA completed for mitapivat in sickle cell disease
sickle cell diseasesource ↗
▲Accelerated Approval PathwayMitapivatApprovedDesignation
FDA recommended accelerated approval pathway for mitapivat in sickle cell disease
sickle cell diseasesource ↗
▲Topline ReadoutMitapivatApprovedClinical Data
RISE UP Phase 3 topline results: hemoglobin response primary endpoint met; pain crises endpoint not statistically significant
sickle cell diseasesource ↗
▲Primary Endpoint MetMitapivatApprovedClinical Data
Hemoglobin response primary endpoint met in RISE UP Phase 3
sickle cell diseasesource ↗
▼Primary Endpoint MissedMitapivatApprovedClinical Data
Annualized rate of sickle cell pain crises primary endpoint did not reach statistical significance
sickle cell diseasesource ↗
▲Trial CompletionMitapivatApprovedTrial
RISE UP Phase 3 double-blind phase completed; 87% of mitapivat arm completed
sickle cell diseasesource ↗
▲OLE InitiatedMitapivatApprovedTrial
Open-label extension phase ongoing for RISE UP
sickle cell diseasesource ↗
▲Other Regulator MilestoneMitapivatApprovedEx-US Regulatory
PYRUKYND approved by Emirates Drug Establishment for adults with thalassemia in UAE
thalassemiasource ↗
▲Other Regulator MilestoneMitapivatApprovedEx-US Regulatory
UAE approved PYRUKYND for thalassemia in March 2026
thalassemiasource ↗
●Oral PresentationPresentation
Conference call and webcast to discuss Q4 and full year 2025 results
◆R&D DayPresentation
Agios management to present at 44th Annual J.P. Morgan Healthcare Conference
▲Product LaunchMitapivatApprovedPost-Market
U.S. commercial launch of AQVESME in thalassemia in late January 2026
thalassemiasource ↗
▲FDA Feedback ReceivedMitapivatApprovedFDA Meeting
Pre-sNDA meeting with FDA completed for mitapivat in sickle cell disease
sickle cell diseasesource ↗
●Timing GuidanceMitapivatApprovedPresentation
Pre-sNDA meeting with FDA planned for Q1 2026
sickle cell diseasesource ↗
▲Product LaunchMitapivatApprovedPost-Market
U.S. commercial launch of AQVESME in thalassemia
alpha- or beta-thalassemiasource ↗
◆Pre NDA MeetingMitapivatApprovedFDA Meeting
Pre-sNDA meeting with FDA for mitapivat in sickle cell disease
sickle cell diseasesource ↗
◆Timing GuidanceMitapivatApprovedPresentation
Potential U.S. approval in thalassemia
thalassemiasource ↗
◆Topline ReadoutMitapivatApprovedClinical Data
Topline results from RISE UP Phase 3 trial in sickle cell disease
sickle cell diseasesource ↗
▲FDA ApprovalMitapivatApprovedFDA Decision
FDA approval of AQVESME for thalassemia
anemia in adults with alpha- or beta-thalassemiasource ↗
◆Oral PresentationMitapivatApprovedPresentation
Long-Term Mitapivat Treatment Improves Inflammatory Pro-Fibrotic Cardiomyopathy in a Murine Model of β-Thalassemia
β-Thalassemiasource ↗
◆Poster PresentationMitapivatApprovedPresentation
Long-Term Transfusion-Free Duration and Impact on Transfusion-Related Burdens: Results from the Ongoing ENERGIZE-T Open-Label Extension Study of Mitapivat in Transfusion-Dependent Alpha- or Beta-Thalassemia
Transfusion-Dependent Alpha- or Beta-Thalassemiasource ↗
◆Poster PresentationPresentation
Understanding Health Literacy Among Patients with Thalassemia: Results from a Global Patient Survey by the Thalassemia Advocacy Advisory Council
Thalassemiasource ↗
◆PDUFA DateMitapivatApprovedRegulatory Filing
PDUFA goal date for mitapivat sNDA in thalassemia
thalassemiasource ↗
◆PDUFA DateMitapivatApprovedRegulatory Filing
PDUFA goal date extended to December 7, 2025 for PYRUKYND sNDA in thalassemia
thalassemiasource ↗
◆Poster PresentationMitapivatApprovedPresentation
Ex Vivo Treatment by Mitapivat Reduced Oxidative Stress to Support Terminal Erythropoiesis of Non-Transfusion Dependent Thalassemia Patients Due to β-Thalassemia/Hb E Disease
Non-Transfusion Dependent Thalassemia (β-Thalassemia/Hb E)source ↗
Past FDA Catalysts and PDUFA Decisions
How AGIO actually traded into and out of each decision
| Date | Drug | Catalyst | Stage | Reaction | Event Move % | Best Trade % |
|---|---|---|---|---|---|---|
| 2026-06-30 | AG-236 | Phase 1 topline data readout | Phase 1 |
Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision
Drug Pipeline Intelligence
C50 / 100
Pipeline Score
$313M
Pipeline Value
$233M
Commercial Value
Richly Valued
Valuation Signal
5
Drugs Scored
0.2x
rNPV / MCap
Top 17%
Micro Cap(rank 113 of 660)
Percentile Rank
Agios Pharmaceuticals, Inc. carries a moderate pipeline score (50/100), with $782M risk-adjusted pipeline value, led by AG-236 in Polycythemia Vera (Phase 2).
Commercial products (revenue basis: trailing 4 quarters of total revenue (10-K and 10-Q), to Jun 2026; product lines: last four quarters to Jun 2026 (10-K and 10-Q)) Revenue $98.3M x 2.4 = $233M
| Product | Revenue | Prior period | Change |
|---|---|---|---|
| PYRUKYND | $98M | $41M | +140.6% |
| Drug | Indication | Phase | PTRS | rNPV | Status | Enroll | Velocity | Design | Est. Completion | ML Signal | Last Change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AG-236 Small moleculeNCT07859423 | Polycythemia Vera | Phase 2 | NOT YET_RECRUITING | 245 | Aug 1, 2032 |
Clinical Trial Results
Readouts, endpoints and source filings for every AGIO program
| Drug Name | Indication | Phase | Date | Trial Results Summary | Title | Source |
|---|---|---|---|---|---|---|
| mitapivat PriorityAccelerated | sickle cell disease | Phase 3 | 2026-06-13 | significant improvement in hemoglobin response compared with placebo; clinically meaningful reduction in transfusion burden compared with placebo; patients in mitapivat arm who achieved hemoglobin response had clinically meaningful benefits across measures of sickle cell pain crises, fatigue, and other patient-reported outcomes; reduction in the annualized rate of sickle cell pain crises (SCPCs) compared with placebo; no overall difference between mitapivat and placebo for the key secondary endpoint measuring patient-reported fatigueRead More | Agios Showcases RISE UP Phase 3 Results at EHA 2026 Plenary Session Reinforcing Strong Anti-Hemolytic Profile of Mitapivat in Sickle Cell DiseaseRead More |
Inside Trades
| Insider | Side | Shares | Price | Value | Date |
|---|---|---|---|---|---|
| Gheuens SarahOfficer (Chief Medical Officer) | Sell | -30,000 54,645 held | $30.48 | 08/04/2026 |
Hedge Fund 13F Activity
Hedge Funds invested in AGIO
| Fund | % of Portfolio | Current MV | Shares Owned | Activity |
|---|---|---|---|---|
| PARKMAN HEALTHCARE PARTNERS LLC | 2.5 % (78.6 %) | 24.83 M | 669.05 K | 65.8% ( 265.52 K) |
AGIO Institutional Ownership Trends
Options Data
Option Volume
Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg
Option Chain Statistics
| Expiry | Call Vol | Put Vol | Vol P/C | Call OI | Put OI | OI P/C | IV Call | IV Call OI-Wtd | IV Call Vol-Wtd | IV Put | IV Put OI-Wtd | IV Put Vol-Wtd |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2027-01-15 | ||||||||||||
Real-Time Option Chain
| Calls | Strike | Puts | ||||
|---|---|---|---|---|---|---|
| Last | Vol | OI | Last | Vol | OI | |
| No data available | ||||||
Calls vs Puts by Expiry
CallsPutsLog scale
Competitive positioning
How AGIO ranks across every disease it competes in
Competitive Position is a premium feature
See how AGIO ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
Start free trialAGIO News
AGIO▼ -0.3%today
Agios to Host Third Quarter 2026 Financial Results Conference Call and Webcast on November 5 at 8:00 a.m. ET
Agios Pharmaceuticals will host a conference call and webcast on November 5, 2026, at 8:00 a.m. ET to discuss its third quarter 2026 financial results and business highlights. The event will be accessible via the company's website, with a replay available shortly after. Agios aims to redefine rare disease treatment through innovative medicines.
Read more →AGIO▼ -6.5%on this news
Agios Reports Second Quarter 2026 Financial Results and Provides Business Update
Agios Pharmaceuticals reported strong financial results for Q2 2026, with net revenues from mitapivat reaching $44.7 million, significantly up from the previous year. The company highlighted the successful U.S. launch of AQVESME for thalassemia and received FDA Priority Review for mitapivat in sickle cell disease. Agios also expanded its pipeline with the licensing of cevidoplenib for immune thrombocytopenia and plans to advance AG-236 into Phase 2/3 development.
Read more →AGIO▼ -6.7%on this news
Agios Provides Update on Phase 2 Trial of Tebapivat in Sickle Cell Disease
Agios Pharmaceuticals announced topline results from its Phase 2 trial of tebapivat in sickle cell disease. While hemoglobin response rates were consistent with the PK activator class, the trial did not demonstrate sufficient differentiation to support further development. Consequently, Agios will not advance tebapivat, focusing instead on mitapivat, which is under FDA Priority Review.
Read more →AGIO▲ +17.7%on this news
U.S. FDA Grants Priority Review to Agios’ sNDA for Mitapivat in Sickle Cell Disease
Agios Pharmaceuticals announced that the FDA has accepted its supplemental New Drug Application for mitapivat, an oral pyruvate kinase activator, in sickle cell disease, granting it Priority Review. If approved by the PDUFA goal date of November 1, 2026, mitapivat could be the first oral treatment for this condition. The application is supported by extensive clinical data from the RISE UP trials.
Read more →AGIOAgios to Host Second Quarter 2026 Financial Results Conference Call and Webcast on July 30 at 8:00 a.m. ET
Agios Pharmaceuticals will host a conference call and webcast on July 30, 2026, at 8:00 a.m. ET to discuss its second quarter financial results and business highlights. The event will be accessible via the company's website, with a replay available shortly after. Agios emphasizes its commitment to transforming rare disease treatment through innovative medicines.
Read more →AGIO▲ +8%on this news
Agios Showcases RISE UP Phase 3 Results at EHA 2026 Plenary Session Reinforcing Strong Anti-Hemolytic Profile of Mitapivat in Sickle Cell Disease
Agios Pharmaceuticals has presented promising results from the RISE UP Phase 3 trial of mitapivat for sickle cell disease at the EHA 2026 Congress. The trial demonstrated significant improvements in hemoglobin response and a notable reduction in transfusion dependency while remaining well-tolerated by patients. However, despite these positives, the primary endpoint for measuring pain crises did not achieve statistical significance. Overall, the data suggests a strong anti-hemolytic profile for mitapivat, highlighting its potential to enhance the quality of life for patients suffering from this condition.
Read more →AGIOAgios Enters Exclusive Global License Agreement with Oscotec to Develop and Commercialize Next-Generation SYK Inhibitor Cevidoplenib
Agios Pharmaceuticals has entered an exclusive global license agreement with Oscotec to develop cevidoplenib, a next-generation SYK inhibitor for immune thrombocytopenia (ITP). The agreement allows Agios to diversify its rare hematology portfolio and potentially achieve up to $1 billion in peak U.S. sales. Cevidoplenib aims to improve treatment outcomes for ITP patients, building on Phase 2 trial data that demonstrated durable platelet responses.
Read more →AGIOAgios Provides Update on Phase 2b Trial of Tebapivat in Lower-Risk Myelodysplastic Syndromes
Agios Pharmaceuticals announced that it will not advance tebapivat for lower-risk myelodysplastic syndromes (LR-MDS) after its Phase 2b trial failed to meet predefined efficacy thresholds. Although the drug was well tolerated and showed biological activity, it did not demonstrate sufficient clinical benefit. The company remains optimistic about tebapivat's potential in treating sickle cell disease, with further data expected later in 2026.
Read more →AGIOResumen: El socio de Avanzanite Bioscience, Agios anuncia la autorización de PYRUKYND® (mitapivat) en la Unión Europea para adultos con talasemia
Agios has announced the authorization of PYRUKYND® (mitapivat) in the European Union for adults with thalassemia. This marks a significant regulatory achievement for the company and its partner, Avanzanite Bioscience. The approval may enhance treatment options for patients suffering from this condition.
Read more →AGIOAgios’ PYRUKYND® (mitapivat) Approved in the European Union for Adults with Thalassemia
Agios Pharmaceuticals has received marketing authorization from the European Commission for PYRUKYND (mitapivat), the first medicine approved in the EU for adults with both transfusion-dependent and non-transfusion-dependent thalassemia. This approval is based on positive results from Phase 3 clinical trials, highlighting the drug's potential to improve patient outcomes. Agios will collaborate with Avanzanite Bioscience for distribution in Europe, further expanding access to this important treatment.
Read more →AGIOAvanzanite Bioscience’s Partner Agios Announces PYRUKYND® (mitapivat) Approval in the European Union for Adults with Thalassaemia
Agios has announced the approval of PYRUKYND® (mitapivat) in the European Union for adult patients with thalassaemia. This marks a significant milestone for Agios and its partner Avanzanite Bioscience. The approval is expected to enhance treatment options for patients suffering from this condition.
Read more →AGIOSamenvatting: Avanzanite Bioscience’s partner Agios maakt de goedkeuring van PYRUKYND® (mitapivat) in de Europese Unie bekend voor volwassenen met thalassemie
Agios has announced the approval of PYRUKYND® (mitapivat) in the European Union for adults with thalassemia. This marks a significant milestone for the company and its partner, Avanzanite Bioscience. The approval is expected to enhance treatment options for patients suffering from this condition.
Read more →AGIORiassunto: Agios, partner di Avanzanite Bioscience, annuncia l'approvazione di PYRUKYND® (mitapivat) nell'Unione europea per gli adulti affetti da talassemia
Agios, in partnership with Avanzanite Bioscience, announced the approval of PYRUKYND® (mitapivat) in the European Union for adults with thalassemia. However, the article provides limited information regarding the implications of this approval or the approval process itself.
Read more →AGIOAgios Submits sNDA to FDA for U.S. Accelerated Approval of Mitapivat in Sickle Cell Disease
Agios Pharmaceuticals has submitted a supplemental New Drug Application (sNDA) to the FDA for mitapivat, aiming for accelerated approval in treating sickle cell disease. The submission follows an agreement with the FDA on a confirmatory clinical trial, which will evaluate the drug's effectiveness in reducing transfusion burden. Mitapivat has shown promising results in previous trials, including improved hemoglobin levels and reductions in related complications. The outcomes from this confirmatory trial are crucial for translating accelerated approval into traditional approval.
Read more →AGIOAgios to Present New Data at EHA 2026 Reinforcing the Significant Therapeutic Impact of Mitapivat Across Multiple Rare Hemolytic Anemias
Agios Pharmaceuticals has announced that new data on mitapivat will be presented at EHA 2026, highlighting its significant therapeutic impact on multiple rare hemolytic anemias. Key presentations will include results from the RISE UP Phase 3 trial, which reported notable improvements in hemoglobin responses and reduced markers of hemolysis in patients with sickle cell disease. The company also plans to share long-term data showing sustained efficacy across various patient populations. This event marks a key opportunity for Agios to engage with the hematology community regarding advancements in treatment options.
Read more →AGIO▲ +13.1%on this news
Agios Reports First Quarter 2026 Financial Results and Provides Business Update
Agios Pharmaceuticals reported a strong first quarter for 2026, with net revenues from mitapivat reaching $20.7 million, a significant increase from the previous year. The company successfully launched AQVESME for thalassemia, with 242 prescriptions written. Agios plans to submit a supplemental New Drug Application for mitapivat in sickle cell disease in Q2 2026, marking a key growth opportunity.
Read more →AGIOAgios to Host First Quarter 2026 Financial Results Conference Call and Webcast on April 29 at 8:00 a.m. ET
Agios Pharmaceuticals, a biopharmaceutical company specializing in rare diseases, announced that it will host a conference call and live webcast on April 29, 2026, at 8:00 a.m. ET to discuss its first quarter 2026 financial results and business highlights. The event will be accessible through the Investors section of Agios' website, where a replay will also be available. The announcement reflects Agios' commitment to keeping investors informed about its operations and financial performance.
Read more →AGIO▲ +14.3%on this newsshared move
Agios Advances Mitapivat Toward Potential U.S. Accelerated Approval in Sickle Cell Disease Following Pre-sNDA Meeting with FDA
Agios Pharmaceuticals is advancing its oral pyruvate kinase activator, mitapivat, toward potential accelerated approval from the FDA for treating sickle cell disease. Following a pre-supplemental New Drug Application meeting, the company plans to submit a formal request for approval and is required to conduct a confirmatory clinical trial. The FDA's feedback emphasized the unmet need for treatment options in this condition, and Agios remains committed to expediting the approval process while ensuring rigorous standards are met.
Read more →AGIOAgios’ PYRUKYND® (mitapivat) Approved for Adults with Thalassemia in the United Arab Emirates
Agios Pharmaceuticals announced the approval of PYRUKYND (mitapivat) for adults with thalassemia in the UAE, marking it as the only treatment available for this condition in the region. The approval is based on successful Phase 3 trial results, highlighting the drug's potential to significantly improve patient outcomes. Agios, in partnership with NewBridge Pharmaceuticals, aims to enhance treatment access for thalassemia patients across the Gulf region.
Read more →About Agios Pharmaceuticals, Inc.
Headquarters88 SIDNEY STREET, CAMBRIDGE, MA, 02139
Founded2007
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