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DISC-0974

Phase 2

Inflammatory Bowel Disease (IBD) | Small molecule | Hematology |Disc Medicine, Inc.|Last Updated: May 4, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment21
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07368972Study of DISC-0974-201 in Participants With IBD and AnemiaPHASE2 RECRUITING 21Feb 20, 2026Mar 1, 2027May 4, 20269 United States
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Study Endpoints
Primary Endpoints
Maximal change from baseline in Hgb through Day 85
up to 85 days
Secondary Endpoints
Incidence of treatment-emergent adverse events
Up to 85 days
Incidence of clinically abnormal vital signs
Up to 85 days
Incidence of clinically abnormal physical exam
Up to 85 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ActiveEXPERIMENTALDISC-0974 60 mg (n = 14) administered subcutaneously (SC) every 28 days for 3 doses
PlaceboPLACEBO_COMPARATORPlacebo (n = 7) administered SC every 28 days for 3 doses
Interventions
NameTypeDescription
DISC-0974DRUGDISC-0974 is administered subcutaneously.
PlaceboDRUGPlacebo is administered subcutaneously
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites9

Inclusion Criteria: Participants must meet all the following criteria at screening (unless otherwise specified) to be eligible for enrollment in the study: 1. Aged ≥18 years at the time of signing informed consent. 2. Established diagnosis of IBD (CD, UC, or IBD-unclassified) based on documented f...

Countries:United States
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Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT07368972primaryCompletionDate: changed
LOWMay 24, 2026NCT07368972studyFirstPostDate: changed