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De Novo Administration of Darbepoetin Alfa

Phase 3

Chronic Kidney Disease | Small molecule | Nephrology |Amgen Inc.|Last Updated: Jul 10, 2009

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment100
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00112008Study for Subjects With Chronic Kidney Disease(CKD) Not Receiving DialysisPHASE3 COMPLETED 100May 1, 2004Mar 1, 2005Jul 10, 2009 -
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Study Endpoints
Primary Endpoints
The proportion of subjects achieving a Hb ≥ 11.0 g/dL
Entire Study
Secondary Endpoints
Hb values over the duration of the study
Entire Study
Darbepoetin alfa doses over the duration of the study
Entire Study
Frequency, severity, and relationship to treatment for adverse events and changes in laboratory parameters and blood pressure
Entire Study
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
darbepoetin alfaEXPERIMENTAL -
Interventions
NameTypeDescription
De Novo Administration of Darbepoetin AlfaDRUGAdministration Q2W for 18 weeks. starting dose is 0.75 mcg/kg rounded to the nearest dose: 20, 30, 40, 50, 60, 80, 100, 150, 200 0r 300 mcg. Titrate to maintain Hb within 11.0 - 13.0 g/dL
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: - Diagnosis of CKD and not expected to initiate dialysis for the duration of the study - Estimated glomerular filtration rate (eGFR): greater than or equal to 15 mL/min and less than or equal to 60 mL/min measured by the following modified MDRD (Modification of Diet in Renal Dise...

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