Recent Updates
Recently added Catalysts

MK-2828

Phase 1

Diabetes Mellitus, Type 2 | Small molecule | Metabolic |Merck & Company, Inc.|Last Updated: May 22, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment46
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07089784Multiple Dose Study of MK-2828 in Participants With Type 2 Diabetes (MK-2828-003)PHASE1 COMPLETED 46Sep 22, 2025May 4, 2026May 22, 202611 United States
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Number of Participants Who Experience an Adverse Event (AE)
Up to approximately 42 days

An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.

Number of Participants Who Discontinue Study Treatment Due to an AE
Up to approximately 28 days

An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.

Secondary Endpoints
Plasma Concentration of MK-2828 at 24 Hours Postdose (C24) After Day 1 Dose
24 hours post-Day 1 dose
Plasma Concentration of MK-2828 at 24 Hours Postdose (C24) After Day 27 Dose
Predose on Day 28
Change from Baseline in Placebo Corrected High-Sensitivity C-Reactive Protein (hsCRP) Serum Concentration
Baseline and Predose Day 28
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
MK-2828EXPERIMENTALParticipants receive daily MK-2828 for 28 days.
PlaceboPLACEBO_COMPARATORParticipants receive daily placebo for 28 days.
Interventions
NameTypeDescription
MK-2828DRUGOral capsule of MK-2828 taken once per day for 28 days.
PlaceboDRUGPlacebo to match MK-2828 oral capsule, taken once per day for 28 days.
Unlock Study Design Details
Eligibility Criteria
Age Range24 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites11

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * With the exception of type 2 diabetes mellitus (T2DM), is in generally good health * Has a history of T2DM for ≥1 year at the time of screening based on self-reporting * Has a baseline HbA1C level of ≤1...

Countries:United States
Unlock Eligibility Criteria
Recent Changes (Last 90 Days)
HIGHMay 26, 2026NCT07089784Status: RECRUITING → COMPLETED
LOWMay 24, 2026NCT07089784studyFirstPostDate: changed