Recent Updates
Recently added Catalysts

TNX-103

Phase 3

Pulmonary Hypertension | Small molecule | Cardiovascular |Tenax Therapeutics, Inc.|Last Updated: Jul 24, 2026

Success Probability
Subscribe to view
Market & Valuation
Subscribe to view
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment230
FDA Designations
No designations recorded
Clinical trial landscape

TNX-103 · 3 trials · 2 indications

Phase 3 3
NCT07436689Long-Term Open-Label Extension Study of Oral LevosimendanPulmonary Hypertension Associated With HFpEF
ENROLLING BY_INVITATION800 Analytics
NCT07288398LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2Pulmonary Hypertension Associated With HFpEF
RECRUITING540 Analytics
NCT05983250LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEFPulmonary Hypertension
ACTIVE NOT_RECRUITING230 Analytics
PHASE3ENROLLING BY_INVITATION
Long-Term Open-Label Extension Study of Oral Levosimendan
Pulmonary Hypertension Associated With HFpEFUnlock trial analytics
PHASE3RECRUITING
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
Pulmonary Hypertension Associated With HFpEFUnlock trial analytics
PHASE3ACTIVE NOT_RECRUITING
LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF
Pulmonary HypertensionUnlock trial analytics
Study Endpoints
Primary Endpoints
The incidence (i.e., the percentage of patients who experience at least 1 occurrence) of select AE/SAEs
From enrollment through study completion (up to 3 years)

The incidence (i.e., the percentage of patients who experience at least 1 occurrence) of select AE/SAEs will be tabulated by system organ class and preferred term.

6-Minute Walk Distance (6MWD)
26 weeks

Change in 6-minute walk distance

Change in Six-minute walk distance
12 weeks
Secondary Endpoints
KCCQ (Kansas City Cardiomyopathy Questionnaire) score is a standardized measure that ranges from 0 to 100, where a higher score indicates better health.
26 weeks
Clinical Worsening Events
26 weeks
Clinical Worsening Event
26 weeks
Unlock Study Endpoints
Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
TNX-103EXPERIMENTALOpen-label oral levosimendan 1-3mg
PlaceboPLACEBO_COMPARATORMatching placebo (oral)
Interventions
NameTypeDescription
TNX-103DRUGOpen-label oral levosimendan 1-3mg
PlaceboDRUGMatching placebo (oral)
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years to 85 Years
SexALL
Healthy VolunteersNo
Study Sites7

Inclusion Criteria: * Completed a TNX-103 parent study * Investigator confirmation that participant may derive clinical benefit from continued access to TNX-103 * Requirements related to childbearing potential, contraception, and egg/sperm donation Exclusion Criteria: * Investigator or Sponsor op...

Countries:United StatesArgentinaAustriaBrazilBulgariaCzechiaFranceGermanyHungaryItalyPolandSouth KoreaSpainTaiwanUnited KingdomCanada
Unlock Eligibility Criteria
Recent Changes (Last 90 Days)
LOWJul 24, 2026NCT05983250primaryCompletionDate: changed
LOWJul 24, 2026NCT05983250primaryCompletionDate: changed
MEDIUMJul 21, 2026NCT05983250Status: RECRUITING → ACTIVE_NOT_RECRUITING
LOWJul 20, 2026NCT07436689lastUpdatePostDate: changed
LOWJul 20, 2026NCT07436689lastUpdatePostDate: changed
LOWMay 26, 2026NCT05983250primaryCompletionDate: changed
LOWMay 26, 2026NCT07288398primaryCompletionDate: changed
LOWMay 26, 2026NCT07436689primaryCompletionDate: changed
LOWMay 24, 2026NCT05983250studyFirstPostDate: changed
LOWMay 24, 2026NCT07288398studyFirstPostDate: changed
LOWMay 24, 2026NCT07436689studyFirstPostDate: changed