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TX000045- Dose A

Phase 2

Pulmonary Hypertension | Small molecule | Cardiovascular |Tectonic Therapeutic, Inc. Common Stock|Last Updated: Jan 29, 2026

Success Probability
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Trial Design
UNCONTROLLED
Total Trials1
Total Enrollment180
FDA Designations
No designations recorded
Clinical trial landscape

TX000045- Dose A · 1 trial · 2 indications

Phase 2 1
NCT06616974A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)Pulmonary Hypertension
RECRUITING180 Analytics
PHASE2RECRUITING
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
Pulmonary HypertensionUnlock trial analytics
Study Design & Arms
Interventions
NameTypeDescription
TX000045- Dose ADRUGThe participants will receive a subcutaneous injection of Dose A of TX000045 every 2 weeks for 24 weeks.
TX000045- Dose BDRUGThe participants will receive subcutaneous injection of Dose B of TX000045 every 4 weeks for 24 weeks where they will alternate between TX000045 and placebo every 2 weeks.
PlaceboDRUGThe participants will receive a subcutaneous injection of placebo every 2 weeks for 24 weeks.
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Recent Changes (Last 90 Days)
LOWMay 24, 2026NCT06616974studyFirstPostDate: changed