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troxacitabine

Phase 2

Leukemia | Small molecule | Oncology |Takeda Pharmaceutical Company Limited|Last Updated: Jun 10, 2021

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment31

FDA Designations

No designations recorded

Clinical trial landscape

troxacitabine · 1 trial · 1 indication

Phase 2 1
NCT00012259Troxacitabine in Treating Patients With Chronic Myelogenous LeukemiaLeukemia
COMPLETED31 Analytics
PHASE2COMPLETED
Troxacitabine in Treating Patients With Chronic Myelogenous Leukemia
LeukemiaUnlock trial analytics

Study Endpoints

Primary Endpoints

Conventional Response Rate
Week 4

Conventional Response Rate defined as the achievement of complete hematologic remission (CHR), partial hematologic remission (PHR), hematologic improvement (HI), partial response (PR), or back to chronic phase (BCP).

Secondary Endpoints

Percent of Patients Returning to Chronic Phase
Throughout the study period of approximately 15 months.
Toxicity Profile
Every 4 weeks throughout the study period of approximately 15 months.
Survival Duration
Throughout the study period of approximately 15 months.
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
troxacitabineEXPERIMENTAL -

Interventions

NameTypeDescription
troxacitabineDRUG -
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Eligibility Criteria

Age Range16 Years to 120 Years
SexALL
Healthy VolunteersNo
Study Sites20

DISEASE CHARACTERISTICS: Diagnosis of Philadelphia chromosome-positive blastic phase chronic myelogenous leukemia (CML) with blasts of non-lymphoid origin Blastic phase defined as: At least 30% blasts in the blood or bone marrow OR Presence of extramedullary infiltration outside the liver or spleen ...

Countries:United StatesCanada
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Competitive Landscape -Leukemia 327 trials

Top 20 of 63 competitors

CompanyTickerTrialsLead PhaseDrugs
Amgen Inc.AMGN8PHASE3Blinatumomab, Low-intensity chemotherapy regimen
Eli Lilly and CompanyLLY9PHASE3Pirtobrutinib, Idelalisib, Bendamustine, Rituximab
BeOne Medicines Ltd. Sponsored ADRONC13PHASE3Sonrotoclax, Zanubrutinib, Venetoclax, Obinutuzumab
AbbVie, Inc.ABBV24PHASE3Venetoclax
AstraZeneca PLCAZN18PHASE3Acalabrutinib, Rituximab, Chlorambucil
Merck & Co., Inc.MRK7PHASE3Nemtabrutinib, Fludarabine, Cyclophosphamide, Bendamustine, Rituximab
Johnson & JohnsonJNJ12PHASE3Ibrutinib, Venetoclax, Chlorambucil, Obinutuzumab
Novartis AG Sponsored ADRNVS21PHASE3Imatinib, Nilotinib, Bosutinib, Dasatinib, Asciminib
Kura Oncology, Inc.KURA5PHASE3Ziftomenib, Venetoclax, Azacitidine, Daunorubicin, Cytarabine
Nurix Therapeutics, Inc.NRIX5PHASE3NX-5948, Pirtobrutinib
Syndax Pharmaceuticals IncSNDX4PHASE3Revumenib, Intensive Chemotherapy Regimen
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK1PHASE3Ponatinib, Imatinib, Vincristine, Dexamethasone, Cytarabine
SELLAS Life Sciences Group, Inc.SLS1PHASE3Galinpepimut-S, Azacitidine, Venetoclax, Decitabine, Cytarabine
Grifols, S.A. Sponsored ADR Class BGRFS1PHASE3Xembify
Bristol-Myers Squibb CompanyBMY7PHASE2Azacitidine
Pfizer Inc.PFE6PHASE2Gemtuzumab ozogamicine- Cytarabine- Gilteritinib
Ascentage Pharma Group International Unsponsored ADRAAPG11PHASE3Olverembatinib
Tango Therapeutics, Inc.TNGX7PHASE3AG-120, Azacitidine
Incyte CorporationINCY6PHASE2Ruxolitinib
Actinium Pharmaceuticals, Inc. (Delaware)ATNM2PHASE3Iomab-B, Conventional Care
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Frequently asked questions about troxacitabine

What is troxacitabine used for?

Troxacitabine is an investigational small molecule being studied for the treatment of leukemia, specifically chronic myelogenous leukemia. It is in Phase 2 clinical development and is not yet approved by regulatory authorities.

Who makes troxacitabine?

Troxacitabine is being developed by Takeda Pharmaceutical Company Limited, which trades under the ticker TAK. The company is conducting clinical trials to evaluate the drug's safety and efficacy in patients with leukemia.

What phase is troxacitabine in?

Troxacitabine is in Phase 2 clinical development. It is an investigational drug, meaning it has not been approved by the FDA or other regulatory agencies. A Phase 2 trial has been completed to assess its effects in patients with chronic myelogenous leukemia.

What clinical trials is troxacitabine in?

Troxacitabine has one completed clinical trial, NCT00012259, titled 'Troxacitabine in Treating Patients With Chronic Myelogenous Leukemia.' This Phase 2 study enrolled 31 participants in the United States and Canada and was not randomized, double-blinded, or controlled.

Is troxacitabine the same as any other drug?

No alternative names for troxacitabine have been reported. It is identified solely by its generic name in clinical trial records and development documentation.