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Actinium Pharmaceuticals, Inc. (Delaware)

ATNM
OvervaluedPharma · Clinical
FDA catalysts, PDUFA dates & pipeline intelligence
$1.08
▲ +0.01 · +0.93%

Financials

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52W LOW $0.7452W HIGH $1.74
Volume
104.87 K
Value Traded
138.26 K
Short % Float
2.29%
-7.69%Week
-12.2%1 Month
+16.13%3 Month
0%6 Month
-85.14%5 Year
-64.24%All Time

Cash Data

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Key Stats

Market Cap
33.96 M
EPS (TTM)
0.36
P/E Ratio
3.00
Ent. Value
-2.52 M
Total Shares
31.44 M
Float Shares
30.89 M
Insiders
1.77%
Institutions
16.83%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
PDUFA
2026
Example Drug
Treatment for example condition requiring FDA review
Phase 3Small MoleculeOncology-
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

ATNM Catalyst Timeline

Dated clinical, regulatory and corporate events for Actinium Pharmaceuticals, Inc. (Delaware)

Catalyst Timeline

Dated clinical, regulatory & corporate events for Actinium Pharmaceuticals, Inc. (Delaware)

598Total events
6Upcoming
100Tier-1 (high impact)
2012 to 2027Coverage

Upcoming catalysts 2

T2Timing Guidance
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Actimab-A
T2Restructuring Layoffs
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Event history 50

▲Patent GrantedActimab-AIP / Competition
Canadian application 3,059,752 entered pre-grant status for Actimab-A + venetoclax combination in AML
acute myeloid leukemia (AML)source ↗
●IND SubmissionActimab-AIND
IND amended to add additional manufacturer for Actimab-A
▲Manufacturing MilestoneActimab-ACMC / Inspection
IND amended to add additional manufacturer for Actimab-A
●Quarterly UpdateCorporate
NYSE American listing plan accepted and plan period granted
▲Other Regulator MilestoneEx-US Regulatory
NYSE Regulation accepted compliance plan and granted plan period through November 27, 2027
◆Restructuring LayoffsCorporate
Deadline to submit compliance plan to NYSE American
◆Oral PresentationATNM-400Presentation
Oral presentation of ATNM-400 data at SNMMI 2026
prostate cancersource ↗
◆Poster PresentationATNM-400Presentation
ATNM-400 poster on prostate cancer models at SNMMI 2026
prostate cancersource ↗
▲Management ChangeCorporate
Appointment of Steffen Heeger as Chief Medical Officer
◆Poster PresentationPresentation
Poster on optimizing chelator-to-antibody ratio for 225Ac-labeled antibodies at SNMMI 2026
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Past FDA Catalysts and PDUFA Decisions

How ATNM actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-04-30ATNM-400 Pre-clinical data readout Pre-clinical
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

D36 / 100
Pipeline Score
$18M
Pipeline Value
Overvalued
Valuation Signal
3
Drugs Scored
0.5x
rNPV / MCap
Top 50%
Micro Cap
(rank 329 of 658)
Percentile Rank
Actinium Pharmaceuticals, Inc. (Delaware) faces pipeline headwinds (36/100), with $569M risk-adjusted pipeline value, led by 131I-apamistamab in Acute Leukemia (Phase 3).
Showing 1 of 3 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
131I-apamistamab Monoclonal antibodyNCT07157514Acute LeukemiaPhase 3 NOT YET_RECRUITING 306Feb 1, 2034
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Clinical Trial Results

Readouts, endpoints and source filings for every ATNM program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
Actimab-A acute myeloid leukemia (AML)2026-04-22significant AML cell killing; robust cytotoxicity observed in primary AML patient samples across key mutations (FLT3, KMT2A, NPM1, IDH1, IDH2, or TP53); demonstrated compelling clinical activity and a manageable safety profile in more than 150 AML patientsRead MoreActinium Highlights Transcriptional Reprogramming as a Key Mechanism Underpinning Mutation-Agnostic Activity of Actimab-A in AML at the 2026 American Association of Cancer Research Annual MeetingRead More
Scroll for more · summaries link to the source press release
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Inside Trades

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InsiderSideSharesPriceValueDate
SETH SANDESHDirector, Officer (Chief Executive Officer)Grant/Award 300,000 305,381 held$0.00 08/17/2022
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
SILVERARC CAPITAL MANAGEMENT, LLC 0.2 % 350.00 K 45.91 K
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ATNM Institutional Ownership Trends

Options Data

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Today vs avg
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Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2027-05-21
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Real-Time Option Chain

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Competitive positioning

How ATNM ranks across every disease it competes in

Competitive Position is a premium feature
See how ATNM ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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ATNM News

ATNM
Sep 4, 2026
ATNMConferences/Events
▲ +19.4%on this news· ran to +36% by day 3

Actinium Pharmaceuticals, Inc. to Present at the H.C. Wainwright 28th Annual Global Investment Conference

Actinium Pharmaceuticals, Inc. will present at the H.C. Wainwright 28th Annual Global Investment Conference from September 14-16, 2026. CEO Sandesh Seth will lead the presentation, and management will be available for one-on-one meetings with investors. The company focuses on developing targeted radiotherapies aimed at improving cancer treatment outcomes.

Read more →
ATNM
Aug 14, 2026
ATNMFDA Updates

Actinium Pharmaceuticals Announces Actimab-A Intellectual Property and Manufacturing Advances and Provides NYSE American Listing Update

Actinium Pharmaceuticals has announced significant advancements in its Actimab-A program, including new patents and expanded manufacturing capacity. These developments are aimed at supporting upcoming clinical milestones in the treatment of hematological malignancies and solid tumors. Additionally, the company has received an extension from NYSE American to regain compliance with listing standards until November 2027.

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ATNM
Jun 3, 2026
ATNMConferences/Events

Actinium Pharmaceuticals Oral Presentation at SNMMI 2026 Highlights ATNM-400 Overcoming Resistance to All Three Approved Androgen Receptor Inhibitors and Offers Flexible, Well-Tolerated Dosing in Prostate Cancer Models

Actinium Pharmaceuticals showcased new findings on ATNM-400 during the SNMMI 2026 Annual Meeting. The data suggests that ATNM-400 may effectively overcome resistance to all three approved androgen receptor inhibitors in prostate cancer. Additionally, the presentation emphasized the drug's flexible and well-tolerated dosing in relevant cancer models.

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ATNM
Jun 3, 2026
ATNMConferences/Events

Actinium Presents New ATNM-400 Data in KRAS and EGFR Mutant Models at SNMMI 2026 Supporting a Mutation-Agnostic Opportunity In Non-Small Cell Lung Cancer

Actinium Pharmaceuticals presented new preclinical data on its investigational treatment, ATNM-400, at the SNMMI 2026 Annual Meeting. The results show that ATNM-400 not only outperformed existing KRAS inhibitors but also demonstrated potent synergy with EGFR-targeting osimertinib, achieving complete tumor regression in models. This positions ATNM-400 as a prospective mutation-agnostic therapy in non-small cell lung cancer (NSCLC), addressing a significant portion of cases where traditional mutation-specific therapies fall short. The data reinforces Actinium's strategy to develop a broadly effective treatment capable of overcoming tumor resistance.

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ATNM
Jun 1, 2026
ATNMConferences/Events
▼ -6.3%on this newsshared move

Actinium Pharmaceuticals Presents New Radiochemistry Data at SNMMI 2026 Demonstrating That CAR Optimization Improves Tumor Targeting and Pharmacokinetics of Actinium-225 Radioconjugates

Actinium Pharmaceuticals presented new radiochemistry data at the SNMMI 2026 Annual Meeting, showcasing the benefits of optimizing the chelator-to-antibody ratio (CAR) in Actinium-225 radioconjugates. The study found that lower-CAR conjugates maintained effective tumor targeting while decreasing off-target uptake in the liver and spleen, thus broadening the therapeutic window. These results underscore Actinium's advanced radiochemistry capabilities and the implications for enhancing the safety and effectiveness of their drug candidates. The findings may significantly influence the design of future radioconjugates in their pipeline.

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ATNM
Jun 1, 2026
ATNMGeneral
▼ -6.3%on this newsshared move

Actinium Appoints Accomplished Oncology Expert Steffen Heeger MD, MSc as Chief Medical Officer to Drive Rejuvenated Pipeline Development

Actinium Pharmaceuticals has appointed Dr. Steffen Heeger as Chief Medical Officer to enhance its development pipeline. Dr. Heeger comes with significant experience in oncology and has been instrumental in successful drug approvals, including the blockbuster Erbitux®. His leadership is anticipated to advance Actinium's projects, including Actimab-A and ATNM-400, as the company prepares for critical clinical trials in the latter half of 2026. Actinium aims to leverage Dr. Heeger's expertise to further its goal of creating effective targeted radiotherapies.

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ATNM
May 29, 2026
ATNMGeneral
▼ -6.3%on this newsshared move

Actinium Pharmaceuticals Receives Two Patent Allowances Spanning Its Actimab-A and Iomab-ACT Programs

Actinium Pharmaceuticals has received Notices of Allowance for two patent applications from the Canadian Intellectual Property Office, enhancing its intellectual property protection for the Actimab-A and Iomab-ACT programs. These patents cover innovative treatments for hematologic malignancies and gene-edited cell-based therapies. The company aims to expand its global patent estate, which now includes approximately 250 patents.

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ATNM
May 29, 2026
ATNMConferences/Events
▼ -6.3%on this newsshared move

Actinium Pharmaceuticals to Present ATNM-400 Program Update at SNMMI 2026 Conference on May 31-June 2 and Provides NYSE American Listing Standards Notice

Actinium Pharmaceuticals announced an update on its ATNM-400 program, showcasing new data at the SNMMI 2026 Annual Meeting. The presentations will highlight ATNM-400's efficacy in treating prostate cancer and non-small cell lung cancer. Additionally, the company received a notice from NYSE American regarding non-compliance with listing standards, prompting the need for a compliance plan.

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ATNM
May 6, 2026
ATNMConferences/Events

Actinium Pharmaceuticals Announces Three SNMMI 2026 Presentations Highlighting Differentiated Profile of ATNM-400 Across Lung and Prostate Cancer and Radioconjugate Optimization

Actinium Pharmaceuticals announced three upcoming presentations at the SNMMI 2026 Annual Meeting, showcasing the potential of ATNM-400 in treating non-small cell lung cancer (NSCLC) and prostate cancer. The data highlights ATNM-400's ability to function as a mutation-agnostic therapy and its effectiveness in PSMA-negative prostate cancer. Additionally, advancements in the radioconjugate's optimization are expected to enhance its therapeutic index.

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ATNM
Apr 22, 2026
ATNMConferences/Events
▼ -7.9%on this news· ran to -20% by day 3

Actinium Highlights Transcriptional Reprogramming as a Key Mechanism Underpinning Mutation-Agnostic Activity of Actimab-A in AML at the 2026 American Association of Cancer Research Annual Meeting

Actinium Pharmaceuticals highlighted the anti-leukemic activity of Actimab-A at the AACR Annual Meeting, emphasizing its mutation-agnostic approach in treating acute myeloid leukemia (AML). Data indicated that Actimab-A combinations led to significant AML cell killing, independent of mutation status, by promoting transcriptional reprogramming. The findings suggest enhanced efficacy when paired with standard-of-care therapies, reinforcing Actimab-A's potential as a universal combination backbone in AML treatment. Additionally, the safety profile observed in previous clinical studies supports its further development as a foundational therapy.

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ATNM
Apr 22, 2026
ATNMConferences/Events
▼ -7.9%on this news· ran to -20% by day 3

Actinium Pharmaceuticals, Inc. Announces Compelling Pan-Tumor Data for ATNM-400 Demonstrating Broad Efficacy Across Prostate, Lung, and Breast Cancer Models at the 2026 American Association of Cancer Research Annual Meeting

Actinium Pharmaceuticals, Inc. has announced promising preclinical data for its novel targeted radiotherapy, ATNM-400, presented at the American Association for Cancer Research Annual Meeting. The data demonstrates the treatment's broad efficacy across various cancer models, including prostate, lung, and breast cancers, outperforming existing therapies in several cases. Notably, ATNM-400 is well tolerated with no significant toxicities observed, enhancing its development potential. The findings suggest that ATNM-400 could provide new options for patients with treatment-resistant tumors.

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ATNM
Apr 6, 2026
ATNMConferences/Events
▲ +11.2%on this news

Actinium Pharmaceuticals Announces New Pan-Tumor Preclinical Data for ATNM-400 in Solid Tumors and Differentiated Mechanism for Actimab-A in AML to be Presented at 2026 AACR Annual Meeting

Actinium Pharmaceuticals has announced new preclinical data for ATNM-400 and Actimab-A, highlighting their potential in treating solid tumors and acute myeloid leukemia (AML), respectively. The data will be presented at the AACR Annual Meeting 2026 in San Diego, showcasing ATNM-400's activity against tumors resistant to targeted therapies and Actimab-A's mutation-agnostic efficacy. Both compounds are positioned to provide significant advancements in cancer treatment, with presentations scheduled for April 21, 2026. The findings are part of Actinium's broader strategy to develop innovative radiotherapies.

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ATNM
Feb 17, 2026
ATNMConferences/Events

Actinium Pharmaceuticals, Inc. to Present Two Abstracts at the 2026 AACR Annual Meeting

Actinium Pharmaceuticals, Inc. (ATNM) has announced the presentation of two abstracts at the 2026 AACR Annual Meeting, scheduled for April 17-22 in San Diego. The presentations will focus on the company's innovative targeted radiotherapies, particularly the ATNM-400 program which targets various cancers including prostate, lung, and breast cancers. The event marks an important opportunity for Actinium to engage with the oncology research community, showcasing their progress in differentiated radiotherapy development. Specific abstract details will be released on March 17, 2026, in accordance with AACR guidelines.

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ATNM
Dec 12, 2025
ATNMPhases

Actinium Pharmaceuticals Presents New Preclinical Data Demonstrating Potent Anti-Tumor Activity of ATNM-400 Across Multiple Breast Cancer Subtypes Including Hormone Receptor-Positive, Triple-Negative, and Tamoxifen- and HER2 Therapy-Resistant Breast Cancer Models at SABCS 2025

Actinium Pharmaceuticals presented new preclinical data for ATNM-400 at the 2025 SABCS, showcasing its strong anti-tumor activity against various breast cancer subtypes, including hormone receptor-positive and triple-negative cancers. The data highlight ATNM-400's potential as a treatment option for patients resistant to standard therapies. The findings support further development of ATNM-400 as a monotherapy or in combination with other treatments.

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ATNM
Dec 1, 2025
ATNMConferences/Events

Actinium Pharmaceuticals Announces ATNM-400 Data Demonstrating Potent Efficacy in Triple-Negative Breast Cancer and Ability to Overcome Endocrine and HER2-Targeted Therapy Resistance Being Presented at the San Antonio Breast Cancer Symposium

Actinium Pharmaceuticals announced promising preclinical data for ATNM-400, a targeted radiotherapy for triple-negative breast cancer and other types. The data, to be presented at the San Antonio Breast Cancer Symposium, indicates strong anti-tumor effects in models resistant to standard therapies. ATNM-400's unique mechanism may offer new hope for patients with limited treatment options.

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ATNM
Nov 4, 2025
ATNMConferences/Events

Actinium Pharmaceuticals, Inc. to Highlight ATNM-400 Data in Hormone-Resistant and HER2-Resistant Breast Cancer at the 2025 San Antonio Breast Cancer Symposium, Expanding Pan-Tumor Profile Across Three Solid Tumor Indications

Actinium Pharmaceuticals will present new preclinical data for ATNM-400 at the 2025 San Antonio Breast Cancer Symposium. The data highlights the efficacy of ATNM-400 in hormone-resistant and HER2-resistant breast cancer, as well as its potential across prostate cancer and non-small cell lung cancer. This therapy aims to address significant unmet needs in these oncology indications.

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ATNM
Nov 3, 2025
ATNMConferences/Events

Actinium Pharmaceuticals, Inc. to Participate in the Stephens Biotechnology Virtual Fireside Chat Conference

Actinium Pharmaceuticals, Inc. announced that its CEO, Sandesh Seth, will participate in the Stephens Biotechnology Virtual Fireside Chat on November 4, 2025. The event will also provide opportunities for one-on-one meetings with investors. Actinium is known for its targeted radiotherapies, including its lead candidate ATNM-400, which shows promise in treating prostate cancer and non-small cell lung cancer.

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ATNM
Oct 27, 2025
ATNMPhases
▼ -8.4%on this news

Actinium Announces Superior Anti-Tumor Activity of ATNM-400 in Lung Cancer Compared to the Leading First, Second and Third-Line Approved EGFR Mutant Therapies and Mechanistic Synergy with Osimertinib at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

Actinium Pharmaceuticals announced promising preclinical data for ATNM-400, a novel radioconjugate targeting non-small cell lung cancer (NSCLC). The data presented at the AACR-NCI-EORTC conference showed that ATNM-400 exhibited superior efficacy, achieving 3-5 times greater tumor growth inhibition compared to existing therapies. Additionally, the combination of ATNM-400 with osimertinib resulted in complete tumor regression in all tested subjects, highlighting its potential as a first-in-class treatment.

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ATNM
Oct 24, 2025
ATNMConferences/Events
▲ +5.7%on this newsshared move

Actinium Pharmaceuticals Presents New Data Demonstrating Potent and Durable Efficacy of ATNM-400, a First-in-Class Multi-Tumor Actinium-225 Radiotherapy, at the 32nd Annual Prostate Cancer Foundation Scientific Retreat

Actinium Pharmaceuticals presented promising preclinical data for ATNM-400 at the 32nd Annual Prostate Cancer Foundation Scientific Retreat. This first-in-class radiotherapy targets a novel antigen and demonstrated superior efficacy compared to PSMA-targeted therapies. Notably, ATNM-400 achieved complete tumor regression in a significant percentage of animal models, showcasing its potential in treating resistant prostate cancer.

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ATNM
Oct 13, 2025
ATNMConferences/Events

Actinium Pharmaceuticals to Unveil the Multi-Tumor Potential of ATNM-400, a First-in-Class Actinium-225 Radiotherapy, with Data in Non-Small Cell Lung Cancer at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

Actinium Pharmaceuticals announced that preclinical data for ATNM-400 in non-small cell lung cancer (NSCLC) will be presented at the AACR-NCI-EORTC conference. This first-in-class Actinium-225 radiotherapy shows promise in overcoming resistance to osimertinib, potentially transforming treatment for patients with EGFR-mutant NSCLC. The drug also demonstrates significant efficacy in prostate cancer.

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About Actinium Pharmaceuticals, Inc. (Delaware)

New York, NY 25 employees actiniumpharma.com
Headquarters100 PARK AVE., 23RD FLOOR, NEW YORK, NY, 10017
Founded27-12-2012
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