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Gleevec and Taxotere

Phase 2

Lung Cancer | Small molecule | Oncology |Novartis AG|Last Updated: Aug 7, 2012

Target and mechanism

Molecular targetABL1, BCR, KIT, PDGFRB
Target classInhibitor
ModalitySmall molecule
ChEMBLCHEMBL941

Also known as Imatinib

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment23

FDA Designations

No designations recorded

Clinical trial landscape

Gleevec and Taxotere · 1 trial · 1 indication

Phase 2 1
NCT00222144Study of Gleevec and Taxotere in Recurrent Non-Small Cell Lung CancerLung Cancer
COMPLETED23 Analytics
PHASE2COMPLETED
Study of Gleevec and Taxotere in Recurrent Non-Small Cell Lung Cancer
Lung CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Response rate
Every 2 cycles of therapy and followup

Secondary Endpoints

Time to progression, survival and correlation of PDGF and PDGFR with outcome.
Baseline, at completion of therapy, 12 months
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTALGleevec and Taxotere

Interventions

NameTypeDescription
Gleevec and TaxotereDRUGGleevec 600 mg QD for 12 months Taxotere IV 30 mg/m2 on day 1, 8 and 15
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * One prior chemotherapy treatment: use of single chemotherapy or a regimen containing more than one drug. Regimen must have a platinum agent (cisplatin or carboplatin). Prior biological treatment won't be counted as chemotherapy treatment. Chemoradiation or prior induction or a...

Countries:United States
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Competitive Landscape -Lung Cancer 281 trials

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Frequently asked questions about Gleevec and Taxotere

What is Gleevec used for?

Gleevec is being studied for use in prostate cancer and lung cancer. It is an investigational small molecule oncology drug being evaluated in Phase 2 clinical trials for these indications. Gleevec is also known as imatinib.

What does Gleevec target?

Gleevec is a kinase inhibitor, belonging to the -tinib class of drugs. It works by targeting kinases, which are enzymes involved in cell signaling and growth. This mechanism is relevant to its evaluation in cancer treatment.

Who makes Gleevec?

Gleevec is developed by Novartis AG, a company traded on the stock exchange under the ticker symbol NVS. Novartis is conducting clinical trials to evaluate Gleevec for prostate cancer and lung cancer.

What phase is Gleevec in?

Gleevec is in Phase 2 clinical development for prostate cancer and lung cancer. It is an investigational drug, meaning it has not been approved by regulatory authorities for these uses and is still undergoing clinical evaluation.

What clinical trials is Gleevec in?

Gleevec has been studied in two completed Phase 2 trials. NCT00222144 evaluated Gleevec with Taxotere in recurrent non-small cell lung cancer with 23 participants. NCT00251225 studied imatinib with docetaxel in prostate cancer with 49 male participants. Both trials were conducted in the United States.

Is Gleevec the same as imatinib?

Yes, Gleevec is the same as imatinib. Imatinib is the generic name for the drug, while Gleevec is a brand name. Clinical trials may refer to the drug by either name, such as in NCT00251225 which uses imatinib in its title.