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Apriso CAP

Phase 1

Ulcerative Colitis | Small molecule | Immunology |Bausch Health Companies Inc.|Last Updated: May 8, 2018

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLED
Total Trials1
Total Enrollment60
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03327558Randomized,Study of APRISO 375 mg Versus the Approved APRISO 375 mg Capsules in Healthy Male and Female SubjectsPHASE1 COMPLETED 60May 15, 2017Aug 18, 2017May 8, 20181 United States
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Study Endpoints
Primary Endpoints
Cmax (Maximum observed plasma concentration)
3 hours after oral dose is taken

Maximum observed plasma concentration levels used for descriptive analysis

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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Apriso 0.375G ER CAPEXPERIMENTALApriso 0.375G ER Cap
APRISO 375 mg extended-release capsulesACTIVE_COMPARATORAPRISO 375 mg ER cap
Interventions
NameTypeDescription
Apriso 0.375G ER CAPDRUGER capsule
APRISO 375 mg extended-release capsulesDRUG375 mg extended-release capsules
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male or female, at least 18 years of age * Body mass index (BMI) between18.5 and below 32.0 kg/m2 (inclusive) * Healthy as determined by a responsible and experienced physician, based on a medical evaluation including medical history, physical examination, ECG and labo...

Countries:United States
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