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Bexarotene

Phase 1

Lung Cancer | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Jul 20, 2010

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment12
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00238628A Phase I/II Study of Bexarotene in Combination With ZD1839 (IRESSA®) in the Treatment of Non-Small Cell Lung CancerPHASE1 COMPLETED 12Apr 1, 2004Dec 1, 2005Jul 20, 20101 United States
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Study Endpoints
Primary Endpoints
Overall response rate (RECIST CRITERIA), time to progression, toxicity
Completed 9/2005
Pharmacokinetic analysis
Completed 12/2005
Median survival
Calculated Spring 2008
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Interventions
NameTypeDescription
BexaroteneDRUG -
IressaDRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria:- Patients must have histologically or cytologically confirmed NSCLC which is stage IIIB with malignant pleural effusion or stage IV and have failed therapy with at least a standard first line chemotherapy regimen, or be intolerant of standard chemotherapy. * Patients may have no...

Countries:United States
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Competitive Landscape -Lung Cancer 290 trials
CompanyTickerTrialsLead PhaseDrugs
Merck & Co., Inc.MRK10PHASE3Pembrolizumab, Olaparib, Etoposide /m^2, Pembrolizumab/Vibostolimab Co-Formulation, Etoposide
Gilead Sciences, Inc.GILD5PHASE3Sacituzumab Govitecan, Topotecan, Amrubicin, Lurbinectedin, Domvanalimab
Amgen Inc.AMGN14PHASE3Tarlatamab, Durvalumab, ABP 234, Pembrolizumab, Lurbinectedin
AstraZeneca PLCAZN32PHASE3Durvalumab, Tremelimumab, Volrustomig, Pembrolizumab, Carboplatin
BioNTech SE Sponsored ADRBNTX6PHASE3Pumitamig, Atezolizumab, Etoposide, Carboplatin, PM8002
Bristol-Myers Squibb CompanyBMY15PHASE3MRTX849, Docetaxel, BMS-986489, Atezolizumab, Carboplatin
Pfizer Inc.PFE13PHASE3PF-08634404, Pembrolizumab, Chemotherapy Regimen 1, PF-07220060, Letrozole
AbbVie, Inc.ABBV4PHASE3ABBV-706, Topotecan, Lurbinectedin, Amrubicin, Telisotuzumab Adizutecan
ArriVent BioPharma, Inc.AVBP6PHASE3furmonertinib , daily, platinum-based chemotherapy, Firmonertinib, JAB-21822, Tislelizumab
Eli Lilly and CompanyLLY3PHASE3Ramucirumab, Erlotinib, Gefitinib, Osimertinib, LY4175408
Jazz Pharmaceuticals Public Limited CompanyJAZZ3PHASE3Atezolizumab, Lurbinectedin, Carboplatin, Etoposide, Durvalumab
Summit Therapeutics IncSMMT1PHASE3AK112
Revolution Medicines, Inc.RVMD2PHASE3daraxonrasib, docetaxel, RMC-6291, RMC-6236, Pembrolizumab
Incyte CorporationINCY3PHASE3Retifanlimab, Pemetrexed, Cisplatin, Carboplatin, Paclitaxel
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK1PHASE3TAK-788, Pemetrexed, Cisplatin, Carboplatin
Regeneron Pharmaceuticals, Inc.REGN5PHASE2BNT116, Cemiplimab, Fianlimab, Pemetrexed, Paclitaxel
ImmunityBio IncIBRX3PHASE3Drug: Nogapendekin alfa inbakicept, Pembrolizumab, Cisplatin or Carboplatin, Nab-paclitaxel OR Pemetrexed, Nab-paclitaxel OR Paclitaxel OR Docetaxel
Immutep Ltd Sponsored ADRIMMP2PHASE3eftilagimod alfa, carboplatin plus paclitaxel, cisplatin or carboplatin + pemetrexed, pembrolizumab, IMP321
GSK plc Sponsored ADRGSK1PHASE3Ris-Rez, Topotecan
Zai Lab Ltd. Sponsored ADRZLAB2PHASE3ZL-1310, Atezolizumab, Carboplatin
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