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Bexarotene

Phase 1

Lung Cancer | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Jul 20, 2010

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

Clinical trial landscape

Bexarotene · 1 trial · 1 indication

Phase 1 1
NCT00238628A Phase I/II Study of Bexarotene in Combination With ZD1839 (IRESSA®) in the Treatment of Non-Small Cell Lung CancerLung Cancer
COMPLETED12 Analytics
PHASE1COMPLETED
A Phase I/II Study of Bexarotene in Combination With ZD1839 (IRESSA®) in the Treatment of Non-Small Cell Lung Cancer
Lung CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Overall response rate (RECIST CRITERIA), time to progression, toxicity
Completed 9/2005
Pharmacokinetic analysis
Completed 12/2005
Median survival
Calculated Spring 2008
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
BexaroteneDRUG -
IressaDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria:- Patients must have histologically or cytologically confirmed NSCLC which is stage IIIB with malignant pleural effusion or stage IV and have failed therapy with at least a standard first line chemotherapy regimen, or be intolerant of standard chemotherapy. * Patients may have no...

Countries:United States
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Competitive Landscape -Lung Cancer 281 trials

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Frequently asked questions about Bexarotene

What is Bexarotene used for in lung cancer?

Bexarotene is an investigational small molecule being studied for the treatment of lung cancer, specifically non-small cell lung cancer. It is in Phase 1 clinical development and has been evaluated in combination with another agent in a completed early-stage trial.

Who is developing Bexarotene?

Bexarotene is being developed by AstraZeneca PLC, a biopharmaceutical company listed on the stock exchange under the ticker symbol AZN. The drug is currently in Phase 1 clinical development for lung cancer.

What phase is Bexarotene in?

Bexarotene is in Phase 1 clinical development for lung cancer. It is an investigational drug and has not been approved by regulatory authorities. One Phase 1 trial has been completed, and the drug is no longer in active clinical trials.

What clinical trials has Bexarotene been in?

Bexarotene has been studied in one clinical trial, identified as NCT00238628. This was a Phase 1/2 study of bexarotene in combination with ZD1839 (Iressa) for the treatment of non-small cell lung cancer. The trial was completed in the United States and enrolled 12 participants.

Is Bexarotene the same as ZD1839?

No, Bexarotene is not the same as ZD1839. Bexarotene is the investigational drug being studied, while ZD1839, also known as Iressa, is a separate agent used in combination with bexarotene in a clinical trial for non-small cell lung cancer.