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BL22

Phase 2

Leukemia | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Jun 22, 2010

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment36

FDA Designations

No designations recorded

Clinical trial landscape

BL22 · 1 trial · 1 indication

Phase 2 1
NCT00074048BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell LeukemiaLeukemia
COMPLETED36 Analytics
PHASE2COMPLETED
BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia
LeukemiaUnlock trial analytics

Study Endpoints

Primary Endpoints

Response rate
After even cycle numbers (2,4,6,8,10)

Secondary Endpoints

Duration of Response: [Timeframe: Date that a response begins with the date that PD is documented.]
30 days after last dose of study drug
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTALBL22 immunotoxin

Interventions

NameTypeDescription
BL22DRUGDosing via IV on Days 1,3, and 5.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

DISEASE CHARACTERISTICS: * Histologically confirmed hairy cell leukemia * CD22-positive disease by fluorescence-activated cell sorting with anti-CD22 antibody * Meets at least 1 of the following indications for treatment: * Absolute neutrophil count less than 1,000/mm\^3 * Hemoglobin less than...

Countries:United States
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Competitive Landscape -Leukemia 327 trials

Top 20 of 63 competitors

CompanyTickerTrialsLead PhaseDrugs
Amgen Inc.AMGN8PHASE3Blinatumomab, Low-intensity chemotherapy regimen
Eli Lilly and CompanyLLY9PHASE3Pirtobrutinib, Idelalisib, Bendamustine, Rituximab
BeOne Medicines Ltd. Sponsored ADRONC13PHASE3Sonrotoclax, Zanubrutinib, Venetoclax, Obinutuzumab
AbbVie, Inc.ABBV24PHASE3Venetoclax
AstraZeneca PLCAZN18PHASE3Acalabrutinib, Rituximab, Chlorambucil
Merck & Co., Inc.MRK7PHASE3Nemtabrutinib, Fludarabine, Cyclophosphamide, Bendamustine, Rituximab
Johnson & JohnsonJNJ12PHASE3Ibrutinib, Venetoclax, Chlorambucil, Obinutuzumab
Novartis AG Sponsored ADRNVS21PHASE3Imatinib, Nilotinib, Bosutinib, Dasatinib, Asciminib
Kura Oncology, Inc.KURA5PHASE3Ziftomenib, Venetoclax, Azacitidine, Daunorubicin, Cytarabine
Nurix Therapeutics, Inc.NRIX5PHASE3NX-5948, Pirtobrutinib
Syndax Pharmaceuticals IncSNDX4PHASE3Revumenib, Intensive Chemotherapy Regimen
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK1PHASE3Ponatinib, Imatinib, Vincristine, Dexamethasone, Cytarabine
SELLAS Life Sciences Group, Inc.SLS1PHASE3Galinpepimut-S, Azacitidine, Venetoclax, Decitabine, Cytarabine
Grifols, S.A. Sponsored ADR Class BGRFS1PHASE3Xembify
Bristol-Myers Squibb CompanyBMY7PHASE2Azacitidine
Pfizer Inc.PFE6PHASE2Gemtuzumab ozogamicine- Cytarabine- Gilteritinib
Ascentage Pharma Group International Unsponsored ADRAAPG11PHASE3Olverembatinib
Tango Therapeutics, Inc.TNGX7PHASE3AG-120, Azacitidine
Incyte CorporationINCY6PHASE2Ruxolitinib
Actinium Pharmaceuticals, Inc. (Delaware)ATNM2PHASE3Iomab-B, Conventional Care
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Frequently asked questions about BL22

What is BL22 used for?

BL22 is an investigational small molecule being studied for the treatment of leukemia, specifically in patients previously treated with cladribine for hairy cell leukemia. It is currently in Phase 2 clinical development and has not been approved by regulatory authorities.

Who makes BL22?

BL22 is being developed by AstraZeneca PLC, a biopharmaceutical company listed on the stock exchange under the ticker symbol AZN. The company is conducting clinical research to evaluate the safety and efficacy of this investigational therapy for leukemia.

What phase is BL22 in?

BL22 is in Phase 2 clinical development. It is an investigational drug, meaning it has not yet received regulatory approval and is still being studied in clinical trials to determine its safety and effectiveness for treating leukemia.

What clinical trials is BL22 in?

BL22 has been studied in one completed Phase 2 clinical trial with the identifier NCT00074048. This trial evaluated BL22 in patients previously treated with cladribine for hairy cell leukemia and enrolled 36 participants in the United States.

Is BL22 FDA approved?

BL22 is not FDA approved. It is an investigational drug currently in Phase 2 clinical development. The completed clinical trial for BL22 was an uncontrolled study, and further research would be needed to establish its safety and efficacy for regulatory approval.