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AZD4694

Phase 2

Alzheimer's Disease | Small molecule | Neurology |AstraZeneca PLC|Last Updated: Jan 30, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment25
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00991419To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid BurdenPHASE2 COMPLETED 25Feb 1, 2010Aug 1, 2011Jan 30, 20131 United States
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Study Endpoints
Primary Endpoints
PET Measurements
Day 1 and Day 7
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeDIAGNOSTIC
Treatment Arms
ArmTypeDescription
AEXPERIMENTAL\[18F\]4694
Interventions
NameTypeDescription
[18F]AZD4694DRUG\[18F\]AZD4694 PET Ligand administered at Visit 1, 30 days following screening and at visit 4 for some of the participants.
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Eligibility Criteria
Age Range18 Years — 80 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Male or female, of any race or/ethnicity * ECG, vital signs, and clinical laboratory values are within normal limits at enrollment or deemed not clinically significant by the physician Exclusion Criteria: * Significant recent (within 6 months) history of neurological (includ...

Countries:United States
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